Spectrum of subclinical and overt hypothyroidism: Effect on thyrotropin, prolactin, and thyroid reserve, and metabolic impact on peripheral target tissues

Staub, J J; Althaus, Beat; Engler, Hanna; Ryff, A; Trabucco, Pia; Marquardt, Katharina; Burckhardt, D; Girard, J.; Weintraub, Bruce D.

doi:10.1016/0002-9343(92)90782-7

Cited by 278 publications

(206 citation statements)

References 34 publications

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“…After further adjustment for potential confounding factors, such as HbA1c, BMI, duration of diabetes, diabetic nephropathy, and hypertension, SCH remained significantly associated with severe diabetic retinopathy (OR 2.086 (1.010-4.307), P = 0.047). There was no significant difference in TSH levels according to the different have been observed in patients with SCH [10,11], and a correlation between diabetic retinopathy and dyslipidemia has been reported [12,13]. Furthermore, statin therapy has been reported to reduce the development or severity of diabetic retinopathy [14,15].…”

Section: Discussionmentioning

confidence: 99%

Association between subclinical hypothyroidism and severe diabetic retinopathy in Korean patients with type 2 diabetes

Kim

Jung

et al. 2011

Endocr J

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Section: Discussionmentioning

confidence: 99%

Association between subclinical hypothyroidism and severe diabetic retinopathy in Korean patients with type 2 diabetes

Kim

Jung

et al. 2011

Endocr J

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“…A number of studies suggest a decrease of TC and LDL-C after L-thyroxine-substitution (11, 15, 24 -27), whereas others report no significant changes (22, 28 -34). It appears that the degree of change depends on two parameters: the initial levels of cholesterol (35,36) and the degree of thyroid dysfunction (17). Indeed, in the subgroups of patients with 'more severe' hypothyroidism (namely TSH $ 10 mU=ml) or high baseline levels of TC ($240 mg/dl), there was a significant response of TC and LDL-C to treatment.…”

Section: Discussionmentioning

confidence: 99%

Lipid profile in subclinical hypothyroidism: is L-thyroxine substitution beneficial?

Efstathiadou¹,

Bitsis²,

Milionis

et al. 2001

European Journal of Endocrinology

115

105

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Objective: The significance of dyslipidemia in subclinical hypothyroidism (SH) and the effect of thyroid substitution on lipids remain controversial. The present study aimed to assess the association of SH with lipid abnormalities and to quantify the effect of L-thyroxine therapy on serum lipid profiles. Design: Serum lipid parameters of 66 patients with SH and 75 age-and sex-matched euthyroid controls were evaluated in a cross-sectional study. Results: Patients with SH had higher total cholesterol (TC) ð222^45 (S.D.) vs 190^32 mg=dlÞ; lowdensity lipoprotein cholesterol (LDL-C) ð139^28 vs 118^39 mg=dlÞ; apolipoprotein B ð149^21 vs 139^18 mg=dlÞ and lipoprotein (a) (Lp(a)) (median 12.5 (0.8-101) mg/dl vs 7 (0.8 -44) mg/dl) levels compared with euthyroid controls (P , 0:05 for all comparisons). In a follow-up study including 37 patients with SH, all measurements were repeated after restoration of a euthyroid state with incremental doses of L-thyroxine. No significant changes in serum lipid profiles were observed except for a decrease in high-density lipoprotein cholesterol ð59^15 to 55^14 mg=dl; P , 0:05Þ: However, patients with high pre-treatment TC ($240 mg/dl) showed a significant reduction in both TC ð278^28 vs 257^36 mg=dl; P , 0:05Þ and LDL-C ð192^23 vs 173^28 mg=dl; P , 0:01Þ levels. Similar but more pronounced changes were observed in a subgroup of patients with pre-treatment levels of TSH $10 mU/ml. Thyroid autoimmunity had no effect on either the baseline or the posttreatment lipid profile. Conclusion: Although patients with subclinical hypothyroidism exhibit increased levels of the atherogenic parameters (mainly LDL-C and Lp(a)), thyroid substitution therapy does not seem to significantly improve dyslipidemia in the whole group of patients.

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“…In overt hypothyroidism, elevated levels of cholesterol and low density lipoprotein cholesterol (LDL-C) and quantitative changes that enhance its susceptibility to oxidation have been well documented (32,33). Therefore, hypothyroidism constitutes a severe atherogenic condition.…”

Section: Effects On Lipidsmentioning

confidence: 99%

Short-term hypothyroidism after Levothyroxine-withdrawal in patients with differentiated thyroid cancer: clinical and quality of life consequences

Duntas¹,

Biondi²

2007

eur j endocrinol

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Acute hypothyroidism induced by thyroid hormone withdrawal in patients with differentiated thyroid cancer during monitoring for remnant or metastatic disease, seriously affects multiple organs and systems, and especially in severe cases can impair quality of life. Indeed, it may induce untoward cardiovascular effects and can be hazardous in patients with underlying cardiovascular disease, particularly in the elderly. Moreover, acute hypothyroidism deranges the lipid profile and exacerbates neuropsychiatric illness. The introduction of recombinant human TSH (rhTSH) as a diagnostic and therapeutic tool in the care of patients with thyroid cancer has widened the scope of disease management. The use of rhTSH prevents derangement of various systems at approximately equivalent societal costs to that of withdrawal and promotes compliance while preserving the patient's normal daily functioning and productivity. Its reliability allied with its safety render this compound a valid alternative in the monitoring of patients with differentiated thyroid carcinoma as well as providing an alternative therapeutic procedure whenever LT4-withdrawal may be hazardous or in cases of patient non-compliance.

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Spectrum of subclinical and overt hypothyroidism: Effect on thyrotropin, prolactin, and thyroid reserve, and metabolic impact on peripheral target tissues

Cited by 278 publications

References 34 publications

Association between subclinical hypothyroidism and severe diabetic retinopathy in Korean patients with type 2 diabetes

Association between subclinical hypothyroidism and severe diabetic retinopathy in Korean patients with type 2 diabetes

Lipid profile in subclinical hypothyroidism: is L-thyroxine substitution beneficial?

Short-term hypothyroidism after Levothyroxine-withdrawal in patients with differentiated thyroid cancer: clinical and quality of life consequences

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