Speech and language impairments in behavioral variant frontotemporal dementia: A systematic review

Géraudie, Amandine; Battista, Petronilla; García, Adolfo M.; Allen, Isabel Elaine; Miller, Zachary A.; Gorno‐Tempini, Maria Luisa; Montembeault, Maxime

doi:10.1101/2021.07.10.21260313

Cited by 6 publications

(7 citation statements)

References 212 publications

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“…Similarly, language disturbances commonly co-occur with the impairment of the socio-emotional behavior in bvFTD. Severity of language deficits seems to be linked with disease severity and frontotemporal atrophy suggesting a close link between bvFTD, speech and language deficits, and disease's core neural disruptions [53]. Finally, we identified a third component, mainly loading to visuo-spatial executive tests.…”

Section: Low Cognitive Dimensional Spacementioning

confidence: 71%

A low-dimensional cognitive-network space in Alzheimer’s disease and frontotemporal dementia

et al. 2022

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Background Alzheimer’s disease (AD) and frontotemporal dementia (FTD) show network dysfunctions linked with cognitive deficits. Within this framework, network abnormalities between AD and FTD show both convergent and divergent patterns. However, these functional patterns are far from being established and their relevance to cognitive processes remains to be elucidated. Methods We investigated the relationship between cognition and functional connectivity of major cognitive networks in these diseases. Twenty-three bvFTD (age: 71±10), 22 AD (age: 72±6), and 20 controls (age: 72±6) underwent cognitive evaluation and resting-state functional MRI. Principal component analysis was used to describe cognitive variance across participants. Brain network connectivity was estimated with connectome analysis. Connectivity matrices were created assessing correlations between parcels within each functional network. The following cognitive networks were considered: default mode (DMN), dorsal attention (DAN), ventral attention (VAN), and frontoparietal (FPN) networks. The relationship between cognition and connectivity was assessed using a bootstrapping correlation and interaction analyses. Results Three principal cognitive components explained more than 80% of the cognitive variance: the first component (cogPC1) loaded on memory, the second component (cogPC2) loaded on emotion and language, and the third component (cogPC3) loaded on the visuo-spatial and attentional domains. Compared to HC, AD and bvFTD showed impairment in all cogPCs (p<0.002), and bvFTD scored worse than AD in cogPC2 (p=0.031). At the network level, the DMN showed a significant association in the whole group with cogPC1 and cogPC2 and the VAN with cogPC2. By contrast, DAN and FPN showed a divergent pattern between diagnosis and connectivity for cogPC2. We confirmed these results by means of a multivariate analysis (canonical correlation). Conclusions A low-dimensional representation can account for a large variance in cognitive scores in the continuum from normal to pathological aging. Moreover, cognitive components showed both convergent and divergent patterns with connectivity across AD and bvFTD. The convergent pattern was observed across the networks primarily involved in these diseases (i.e., the DMN and VAN), while a divergent FC-cognitive pattern was mainly observed between attention/executive networks and the language/emotion cognitive component, suggesting the co-existence of compensatory and detrimental mechanisms underlying these components.

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Section: Low Cognitive Dimensional Spacementioning

confidence: 71%

A low-dimensional cognitive-network space in Alzheimer’s disease and frontotemporal dementia

et al. 2022

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“…Evidence from other world regions reveals general patterns of affected and spared linguistic functions across bvFTD cohorts, with marked variability for some domains (23). Available results come mainly from studies from North America, Western Europe and Australia, with a marked predominance of English over other languages.…”

Section: The General Linguistic Profile Of Bvftdmentioning

confidence: 99%

Language in Behavioral Variant Frontotemporal Dementia: Another Stone to Be Turned in Latin America

et al. 2021

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Beyond canonical deficits in social cognition and interpersonal conduct, behavioral variant frontotemporal dementia (bvFTD) involves language difficulties in a substantial proportion of cases. However, since most evidence comes from high-income countries, the scope and relevance of language deficits in Latin American bvFTD samples remain poorly understood. As a first step toward reversing this scenario, we review studies reporting language measures in Latin American bvFTD cohorts relative to other groups. We identified 24 papers meeting systematic criteria, mainly targeting phonemic and semantic fluency, naming, semantic processing, and comprehension skills. The evidence shows widespread impairments in these domains, often related to overall cognitive disturbances. Some of these deficits may be as severe as in other diseases where they are more widely acknowledged, such as Alzheimer's disease. Considering the prevalence and informativeness of language deficits in bvFTD patients from other world regions, the need arises for more systematic research in Latin America, ideally spanning multiple domains, in diverse languages and dialects, with validated batteries. We outline key challenges and pathways of progress in this direction, laying the ground for a new regional research agenda on the disorder.

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“…Of note, a number of patients do not fit criteria for any of the three core syndromes, often called PPA-unclassified, atypical PPA, or PPA-not otherwise specified (PPA-NOS) [10][11][12]. Features of each of the language variants have been described in people with bvFTD, but few studies have been performed to investigate the type or extent of linguistic impairment in bvFTD, and little is known about whether there are particular clinico-pathological associations for any of the symptoms [8,13,14].…”

Section: Introductionmentioning

confidence: 99%

Language impairment in the genetic forms of behavioural variant frontotemporal dementia

Samra

MacDougall²,

Bouzigues³

et al. 2022

J Neurol

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Background Behavioural variant fronto-temporal dementia (bvFTD) is characterised by a progressive change in personality in association with atrophy of the frontal and temporal lobes. Whilst language impairment has been described in people with bvFTD, little is currently known about the extent or type of linguistic difficulties that occur, particularly in the genetic forms. Methods Participants with genetic bvFTD along with healthy controls were recruited from the international multicentre Genetic FTD Initiative (GENFI). Linguistic symptoms were assessed using items from the Progressive Aphasia Severity Scale (PASS). Additionally, participants undertook the Boston Naming Test (BNT), modified Camel and Cactus Test (mCCT) and a category fluency test. Participants underwent a 3T volumetric T1-weighted MRI, with language network regional brain volumes measured and compared between the genetic groups and controls. Results 76% of the genetic bvFTD cohort had impairment in at least one language symptom: 83% C9orf72, 80% MAPT and 56% GRN mutation carriers. All three genetic groups had significantly impaired functional communication, decreased fluency, and impaired sentence comprehension. C9orf72 mutation carriers also had significantly impaired articulation and word retrieval as well as dysgraphia whilst the MAPT mutation group also had impaired word retrieval and single word comprehension. All three groups had difficulties with naming, semantic knowledge and verbal fluency. Atrophy in key left perisylvian language regions differed between the groups, with generalised involvement in the C9orf72 group and more focal temporal and insula involvement in the other groups. Correlates of language symptoms and test scores also differed between the groups. Conclusions Language deficits exist in a substantial proportion of people with familial bvFTD across all three genetic groups. Significant atrophy is seen in the dominant perisylvian language areas and correlates with language impairments within each of the genetic groups. Improved understanding of the language phenotype in the main genetic bvFTD subtypes will be helpful in future studies, particularly in clinical trials where accurate stratification and monitoring of disease progression is required.

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Speech and language impairments in behavioral variant frontotemporal dementia: A systematic review

Cited by 6 publications

References 212 publications

A low-dimensional cognitive-network space in Alzheimer’s disease and frontotemporal dementia

A low-dimensional cognitive-network space in Alzheimer’s disease and frontotemporal dementia

Language in Behavioral Variant Frontotemporal Dementia: Another Stone to Be Turned in Latin America

Language impairment in the genetic forms of behavioural variant frontotemporal dementia

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