Speech defects of parkinsonian patients

Nakano, Kosuke; Zubick, Howard H.; Tyler, H. Richard

doi:10.1212/wnl.23.8.865

Cited by 50 publications

(13 citation statements)

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“…One may presume that dopaminergic treatment would reduce perioral stiffness in patients with PD, yet those in this investigation demonstrated a greater quadratic function slope in perioral stiffness after the administration of levodopa. These findings are in apparent contradiction to previous studies of orofacial biomechanics and electromyograms that focused on the neurophysiology of speech articulators and found a beneficial effect of levodopa (Leanderson et al, 1971;Nakano, Zubick, & Tyler, 1973). However, the finding in the current study that perioral stiffness increased during the M-ON state corresponds with the increased central drive as reflected in the OOIm IEMG.…”

Section: Muscular Stiffness In Perioral Musclescontrasting

confidence: 99%

Face-Referenced Measurement of Perioral Stiffness and Speech Kinematics in Parkinson's Disease

Chu

Barlow

Lee

2015

J Speech Lang Hear Res

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Purpose Perioral biomechanics, labial kinematics, and associated electromyographic signals were sampled and characterized in individuals with Parkinson's disease (PD) as a function of medication state. Method Passive perioral stiffness was sampled using the OroSTIFF system in 10 individuals with PD in a medication ON and a medication OFF state and compared to 10 matched controls. Perioral stiffness, derived as the quotient of resultant force and interoral angle span, was modeled with regression techniques. Labial movement amplitudes and integrated electromyograms from select lip muscles were evaluated during syllable production using a 4-D computerized motion capture system. Results Multilevel regression modeling showed greater perioral stiffness in patients with PD, consistent with the clinical correlate of rigidity. In the medication-OFF state, individuals with PD manifested greater integrated electromyogram levels for the orbicularis oris inferior compared to controls, which increased further after consumption of levodopa. Conclusions This study illustrates the application of biomechanical, electrophysiological, and kinematic methods to better understand the pathophysiology of speech motor control in PD.

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Section: Muscular Stiffness In Perioral Musclescontrasting

confidence: 99%

Face-Referenced Measurement of Perioral Stiffness and Speech Kinematics in Parkinson's Disease

Chu

Barlow

Lee

2015

J Speech Lang Hear Res

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“…Although dopamine agonists have been noted to improve tremor, bradykinesia, rigidity, and postural abnormalities in patients (Rascol et al, 2002), it is still unclear to what extent medication improves PD voice and speech. Medication has been reported to improve subjective rating and intelligibility scores of PD speech (Nakano et al, 1973;Solomon and Hixon, 1993;De Letter et al, 2005) but there is not yet evidence that medication leads to consistent changes in F0. Two previous studies on the effects of medication on mean F0 have found no difference between ON and OFF medication (Jiang et al, 1999;Goberman et al, 2002).…”

Section: B Effects Of Medication In Speakers With Pdmentioning

confidence: 99%

Relative fundamental frequency during vocal onset and offset in older speakers with and without Parkinson's disease

Stepp

2013

The Journal of the Acoustical Society of America

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The relative fundamental frequency (RFF) surrounding production of a voiceless consonant has previously been shown to be lower in speakers with hypokinetic dysarthria and Parkinson's disease (PD) relative to age/sex matched controls. Here RFF was calculated in 32 speakers with PD without overt hypokinetic dysarthria and 32 age and sex matched controls to better understand the relationships between RFF and PD progression, medication status, and sex. Results showed that RFF was statistically significantly lower in individuals with PD compared with healthy age-matched controls and was statistically significantly lower in individuals diagnosed at least 5 yrs prior to experimentation relative to individuals recorded less than 5 yrs past diagnosis. Contrary to previous trends, no effect of medication was found. However, a statistically significant effect of sex on offset RFF was shown, with lower values in males relative to females. Future work examining the physiological bases of RFF is warranted.

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“…4 Frontotemporal dementia and MND (FTD-MND) also coexist and is relatively easily recognized. 5 The pathological findings in these diseases are known and can be predicted from the presenting clinical features. The deposition of abnormally phosphorylated protein characterizes FTDP-17 6 and ALS/PDC, 7 while the nonspecific protein ubiquitin characterizes FTD-MND.…”

Section: Introductionmentioning

confidence: 99%

Changes induced by levodopa and subthalamic nucleus stimulation on parkinsonian speech

et al. 2005

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Levodopa (L‐dopa) and subthalamic nucleus (STN) stimulation treatments have been associated with both improvement and exacerbation of dysarthria in Parkinson's disease (PD). We report four cases illustrating variant responses of dysarthria to dopaminergic and STN stimulation therapies. Patients' motor disability and dysarthria were perceptually rated by the Unified Parkinson's Disease Rating Scale (UPDRS) in four conditions according to medication and STN stimulation. Dedicated software packages allowed acquisition and analysis of acoustic recordings. Case 1, who had a severe off period aphonia, experienced improvement of speech induced by both levodopa and STN stimulation. In Case 2, both treatments worsened speech due to the appearance of dyskinesias. Case 3 had a dysarthria exacerbation induced by STN stimulation with parameters above optimal levels, interpreted as current diffusion from the STN to corticobulbar fibers. In Case 4, dysarthria exacerbation occurred with stimulation at an electrode contact located caudally to the target, also arguing for current diffusion as a potential mechanism of speech worsening. The presented cases demonstrated variant effects in relation to L‐dopa and STN stimulation on speech. It seems that motor speech subcomponents can be improved like other limb motor aspect, but that complex coordination of all speech anatomical substrates is not responsive to STN stimulation. These hypotheses may be helpful for better understanding and management of STN stimulation effects on motor speech and skeleton–motor subsystems. © 2005 Movement Disorder Society

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Speech defects of parkinsonian patients

Cited by 50 publications

References 0 publications

Face-Referenced Measurement of Perioral Stiffness and Speech Kinematics in Parkinson's Disease

Face-Referenced Measurement of Perioral Stiffness and Speech Kinematics in Parkinson's Disease

Relative fundamental frequency during vocal onset and offset in older speakers with and without Parkinson's disease

Changes induced by levodopa and subthalamic nucleus stimulation on parkinsonian speech

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