Speech disorders in neurofibromatosis type 1: a sample survey

Abstract

The results indicate that speech difficulties are an area of interest in the NF1 population. Further research to elucidate these findings is needed.

A clinical and genetic overview of 18 years neurofibromatosis type 1 molecular diagnostics in the Netherlands

“…Most minor features were found (in index patients fulfilling the NF1 criteria) in a frequency comparable with that described in literature (30,(35)(36)(37)(38). Speaking problems were observed in 16.7%, which is much lower than the 65% previously reported (39). This might be caused by the fact that mild speaking problems (e.g.…”

Clinical characterisation of 29 neurofibromatosis type-1 patients with molecularly ascertained 1.4 Mb type-1 NF1 deletions

“…Reduced speech intelligibility was observed in 14 patients (48%); this feature has not previously been reported in association with large NF1 deletions. Although the overall prevalence of speech disorders in NF1 is not yet known, speech difficulties generally appear to occur more frequently in patients with NF1 as compared to the normal population 44 45. Speech difficulties due to deficits in articulation occur in ∼25% of children with NF1 46…”

Voice Characteristics in Adults With Neurofibromatosis Type 1

“…25 As only VC showed significant differences between NF1 patients and controls, we cannot corroborate the occurrence of poor strength, weakness of the voice, and speech respiration problems as suggested by some authors. 15,18,20 Generally, the respiration in function of phonation seems to be sufficient in NF1 patients.…”