Speech evoked auditory brainstem response and gap detection threshold in middle-aged individual

Sanju, Himanshu Kumar; Bohra, Vaishnavi; Sinha, Sujeet Kumar

doi:10.1007/s00405-016-4402-x

Cited by 4 publications

(2 citation statements)

References 46 publications

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“…The small shift of age-related slowing of conduction time did not lead to significant changes in the brainstem and auditory midbrain gap sensitivity in normal hearing aging mice. When controlled for peripheral hearing loss, gap detection thresholds in aging humans also remain at maximum limited to millisecond changes, with old subjects often exhibiting very good gap detection thresholds, challenging the idea of an automatic uniform decline during aging (Snell, 1997; Strouse et al, 1998; Walton et al, 1998; Harris et al, 2012; Palmer and Musiek, 2014; Hoover et al, 2015; Ozmeral et al, 2016; Sanju et al, 2017). In humans, gap thresholds shifts are limited to the millisecond range (Palmer and Musiek, 2014), with surprisingly precise ABR gap sensitivity in aged subjects (Poth et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Stability of neural representations in the auditory midbrain across the lifespan despite age-related brainstem delays

Land

Kral

2022

Preprint

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The extent to which aging of the central auditory pathway impairs auditory perception in the elderly independent of peripheral cochlear decline is debated. To cause auditory deficits in normal hearing elderly, central aging needs to degrade neural sound representations at some point along the auditory pathway. However, inaccessible to psychophysical methods, the level of the auditory pathway at which aging starts to effectively degrade neural sound representations remains poorly differentiated. Here we tested how potential age-related changes in the auditory brainstem affect the stability of spatiotemporal multiunit complex speech-like sound representations in the auditory midbrain of old normal hearing CBA/J mice. Although brainstem conduction speed slowed down in old mice, the change was limited to the sub-millisecond range and only minimally affected temporal processing in the midbrain (i.e. gaps-in-noise sensitivity). Importantly, besides the small delay, multiunit complex temporal sound representations in the auditory midbrain did not differ between young and old mice. This shows that although small age-related neural effects in simple sound parameters in the lower brainstem may be present in aging they do not effectively deteriorate complex neural population representations at the level of the auditory midbrain when peripheral hearing remains normal. This result challenges the widespread belief of pure central auditory decline as an automatic consequence of aging. However, the stability of midbrain processing in aging emphasizes the role of undetected 'hidden' peripheral damage and accumulating effects in higher cortical auditory-cognitive processing explaining perception deficits in 'normal hearing' elderly.

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Section: Discussionmentioning

confidence: 99%

Stability of neural representations in the auditory midbrain across the lifespan despite age-related brainstem delays

Land

Kral

2022

Preprint

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“…Reduced temporal resolution skills (i.e., higher gap detection thresholds) have been reported in individuals with peripheral hearing loss Fitzgibbons & Gordon-Salant [55], Glasberg [56], Mishra [57], Moore [2] and auditory processing disorders Boscariol [58], Dias [59], which may underlie their poor speech perception. In a study by Sanju [60], gap detection thresholds and speech-ABR results were compared between young and middle-aged adults with normal hearing. As reported, significant differences in the test results were found between the two age groups.…”

Section: Phoneme Transition Measure Of Speech-abrmentioning

confidence: 99%

Speech-Evoked Auditory Brainstem Response in Children with Sensorineural Hearing Loss

Jalaeia¹

2019

GJO

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Speech-evoked auditory brainstem response (speech-ABR) provides an objective documentation of temporal and spectral encoding of speech cues in the brainstem region. As such, the influence of peripheral hearing loss on speech-ABR has been studied but the current literature is limited. The aim of the present study was to compare speech-ABR findings between children with moderate-to-severe SNHL and their agematched normal peers. In this case control study, 17 hearing-impaired (HI) children (mean age = 7.1 ± 1.8 years) and 15 typically developing (TD) children (mean age = 6.1 ± 1.6 years) were enrolled. All HI children had bilateral moderately severe sensorineural hearing loss. The speech-ABR was recorded from HI and TD children to 40-ms speech syllable /da/ presented repetitively at 30 dB sensation level (SL). Statistically longer latencies were found in HI children than in TD children for onset peaks (V and A) and transition portion (peak C) (p < 0.05) with very large effect sizes (d = 1.16 -6.10). In contrast, the sustained components (peaks D, E and F) and offset portion (peak O) of speech-ABR were unaffected by hearing loss (p > 0.05). For speech-ABR composite onset measures, TD children revealed larger VA inter-peak amplitudes (d = 0.87) and steeper VA slopes (d = 1.36) compared to HI children (p < 0.05). Children with moderately severe sensorineural hearing loss had abnormal encoding of speech sounds within the brainstem region. Based on the study outcomes, the usefulness of speech-ABR can be expanded by studying the speech encoding ability in multi-handicapped children).

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Stability of complex sound representations in the auditory midbrain across the lifespan despite age-related brainstem delays

Land

Kral

2023

Hearing Research

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Speech evoked auditory brainstem response and gap detection threshold in middle-aged individual

Cited by 4 publications

References 46 publications

Stability of neural representations in the auditory midbrain across the lifespan despite age-related brainstem delays

Stability of neural representations in the auditory midbrain across the lifespan despite age-related brainstem delays

Speech-Evoked Auditory Brainstem Response in Children with Sensorineural Hearing Loss

Stability of complex sound representations in the auditory midbrain across the lifespan despite age-related brainstem delays

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