‘Speed‐ageing’ of human skin in serum‐free organ culture ex vivo: An instructive novel assay for preclinical human skin ageing research demonstrates senolytic effects of caffeine and 2,5‐dimethylpyrazine
Max van Lessen,
Andrei Mardaryev,
David Broadley
et al.
Abstract:Preclinical human skin ageing research has been limited by the paucity of instructive and clinically relevant models. In this pilot study, we report that healthy human skin of different age groups undergoes extremely accelerated ageing within only 3 days, if organ‐cultured in a defined serum‐free medium. Quantitative (immuno‐)histomorphometry documented this unexpected ex vivo phenotype on the basis of ageing‐associated biomarkers: the epidermis showed significantly reduced rete ridges and keratinocyte prolife… Show more
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