Speed of facial affect intensity recognition as an endophenotype of first-episode psychosis and associated limbic-cortical grey matter systems

Dean, AM; Goodby, Emmeline; Ooi, Cinly; Nathan, Pradeep J.; Lennox, Belinda; Scoriels, Linda; Shabbir, Shaila; Suckling, John; Jones, Peter B.; Bullmore, Edward T.; Barnes, Anna

doi:10.1017/s0033291712001341

Cited by 14 publications

(8 citation statements)

References 64 publications

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“…There were some limitations in this study. Although Dean et al (2013) showed that diminished FAR processing speed rather than accuracy may be characteristic of FEP patients, here, we did not capture reaction times and, hence, potential intervention effects on patients' processing speed were not examined. Second, as FAR was assessed through full-intensity emotional expressions, any intervention effect on the recognition of subtle facial expressions in these patients remains to be further investigated.…”

Section: Discussionmentioning

confidence: 99%

Improved facial affect recognition in patients with first‐episode psychosis

Bozikas

Dardagani

Parlapani

et al. 2018

Early Intervention Psych

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Aim: The present study aimed at assessing whether impaired facial affect recognition (FAR) in patients with first-episode psychosis (FEP) would improve after a brief intervention targeting FAR specifically.Methods: Thirty-five outpatients and 38 healthy controls were administered an intervention which involved training to recognize emotional information, conveyed by changes in facial features. Using a pre-and post-intervention design, two measurements of FAR were conducted using an experimental procedure with alternative sets of stimuli.Results: We found improved overall FAR performance in both participant groups with marked effects in recognizing anger, disgust and fear. Patients' post-intervention performance was comparable to healthy participants' baseline performance.Conclusions: The present improvement in facial affects recognition in FEP patients, despite only somewhat impaired, emphasizes the importance of early targeted interventions for FAR in psychosis. Further research is needed to assess whether this improvement will generalize to global social functioning. K E Y W O R D Searly psychosis, emotion perception, facial affect, intervention, negative valence

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Section: Discussionmentioning

confidence: 99%

Improved facial affect recognition in patients with first‐episode psychosis

Bozikas

Dardagani

Parlapani

et al. 2018

Early Intervention Psych

View full text Add to dashboard Cite

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“…68, 69 Shared variance between family members in brain-behavior networks implicated in fear processing is particularly interesting in light of the social context in which fear is learned, 70 as childhood adversity has been shown to either improve 71, 72 or impair fear recognition performance. 73 Comparisons between CDIs and their siblings who share adverse childhood experiences 74 may thus provide insight into compensatory mechanisms in fear processing in those siblings who do not abuse drugs, possibly elucidating sources of resilience.…”

Section: Discussionmentioning

confidence: 99%

In the face of threat: neural and endocrine correlates of impaired facial emotion recognition in cocaine dependence

et al. 2015

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The ability to recognize facial expressions of emotion in others is a cornerstone of human interaction. Selective impairments in the recognition of facial expressions of fear have frequently been reported in chronic cocaine users, but the nature of these impairments remains poorly understood. We used the multivariate method of partial least squares and structural magnetic resonance imaging to identify gray matter brain networks that underlie facial affect processing in both cocaine-dependent (n=29) and healthy male volunteers (n=29). We hypothesized that disruptions in neuroendocrine function in cocaine-dependent individuals would explain their impairments in fear recognition by modulating the relationship with the underlying gray matter networks. We found that cocaine-dependent individuals not only exhibited significant impairments in the recognition of fear, but also for facial expressions of anger. Although recognition accuracy of threatening expressions co-varied in all participants with distinctive gray matter networks implicated in fear and anger processing, in cocaine users it was less well predicted by these networks than in controls. The weaker brain-behavior relationships for threat processing were also mediated by distinctly different factors. Fear recognition impairments were influenced by variations in intelligence levels, whereas anger recognition impairments were associated with comorbid opiate dependence and related reduction in testosterone levels. We also observed an inverse relationship between testosterone levels and the duration of crack and opiate use. Our data provide novel insight into the neurobiological basis of abnormal threat processing in cocaine dependence, which may shed light on new opportunities facilitating the psychosocial integration of these patients.

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“…The goal of this “Behavioral PLS” is to take 2 multivariate matrices (one for behavioral variables and the other for brain variables) and find the combination of LVs from the brain and behavioral matrices that express the largest amount of common information (i.e., largest covariance) ( McIntosh and Lobaugh 2004 ; Krishnan et al 2011 ). This has been applied in studies of obsessive-compulsive disorder, autism, and psychotic disorder ( Menzies et al 2007 ; Ecker et al 2012 ; Dean et al 2013 ). In our case, this “1-group PLS” analysis identifies the set of brain voxels most correlated with the LV underlying the 3 current language measures in male adults with ASC.…”

Section: Methodsmentioning

confidence: 99%

Neuroanatomy of Individual Differences in Language in Adult Males with Autism

et al. 2014

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One potential source of heterogeneity within autism spectrum conditions (ASC) is language development and ability. In 80 high-functioning male adults with ASC, we tested if variations in developmental and current structural language are associated with current neuroanatomy. Groups with and without language delay differed behaviorally in early social reciprocity, current language, but not current autistic features. Language delay was associated with larger total gray matter (GM) volume, smaller relative volume at bilateral insula, ventral basal ganglia, and right superior, middle, and polar temporal structures, and larger relative volume at pons and medulla oblongata in adulthood. Despite this heterogeneity, those with and without language delay showed significant commonality in morphometric features when contrasted with matched neurotypical individuals (n = 57). In ASC, better current language was associated with increased GM volume in bilateral temporal pole, superior temporal regions, dorsolateral fronto-parietal and cerebellar structures, and increased white matter volume in distributed frontal and insular regions. Furthermore, current language–neuroanatomy correlation patterns were similar across subgroups with or without language delay. High-functioning adult males with ASC show neuroanatomical variations associated with both developmental and current language characteristics. This underscores the importance of including both developmental and current language as specifiers for ASC, to help clarify heterogeneity.

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Speed of facial affect intensity recognition as an endophenotype of first-episode psychosis and associated limbic-cortical grey matter systems

Abstract: Speed of facial affect processing presents as a candidate endophenotype of FEP. The normal association between speed of facial affect processing and cortico-limbic GM variation was disrupted in FEP patients and their relatives.

Cited by 14 publications

References 64 publications

Improved facial affect recognition in patients with first‐episode psychosis

Improved facial affect recognition in patients with first‐episode psychosis

In the face of threat: neural and endocrine correlates of impaired facial emotion recognition in cocaine dependence

Neuroanatomy of Individual Differences in Language in Adult Males with Autism

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