Sperm biology and male reproductive health

Bertolla, Ricardo Pimenta

doi:10.1038/s41598-020-78861-7

Cited by 17 publications

(3 citation statements)

References 19 publications

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“…Spermatogenesis is a programmed, multigene, and complex process (3)(4)(5)(6)(7). Any abnormality in any link may lead to the stagnation of spermatogenesis, which may then lead to severe oligozoospermia or azoospermia (8)(9)(10). The deletion of azoospermia factor (AZF) confirmed by a large number of studies is a typical example.…”

Section: Discussionmentioning

confidence: 99%

Analysis of copy number variations of the autosomal genome in 156 patients with azoospermia

Liu¹,

Shi²,

Zhang³

et al. 2022

Transl Androl Urol

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Background:To analyze the relationship between copy number variations (CNVs) and azoospermia by analyzing the chromosome gene copy data of 156 patients with azoospermia.Methods: A total of 156 azoospermia patients who were treated in our hospital from October 2018 to May 2021 were selected. Informed consent was signed, and semen analysis, testicular biopsy, and chromosome gene detection were carried out. CNVs were analyzed by next-generation sequencing (NGS) detection, and the obtained results were statistically analyzed.Results: Among the 156 azoospermia patients, 81 cases had sperm in the testicular puncture and 75 cases had no sperm in the testicular puncture. There was a significant difference in CNV detection between the 2 groups (P<0.05). Detailed analysis of CNVs on chromosomes 2, 3, 5, 10, and 11 yielded the following results: 132 genes were found in autosomal chromosomes with CNVs and the percentage was >5%, including 8 deletions and 124 repetitions; CNVs on chromosome 2 found 11 genes, of which 3 were deleted and 8 were duplicated; 17 genes were found in CNVs on chromosome 3, including 3 deletions and 14 duplications; 12 genes were found in CNVs on chromosome 5, of which 2 were deleted and 10 were repeated; 72 genes were found in CNVs on chromosome 10, all of which were duplicates; CNVs on chromosome 11 found 20 genes, all of which were duplicates. Conclusions:The chromosome changes caused by CNVs in structure or function may affect the component of spermatogenesis, interfere with mitosis and/or meiosis in the process of spermatogenesis, and lead to azoospermia.

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Section: Discussionmentioning

confidence: 99%

Analysis of copy number variations of the autosomal genome in 156 patients with azoospermia

Liu¹,

Shi²,

Zhang³

et al. 2022

Transl Androl Urol

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“…Increase in litter size and decrease in the number of deformed piglets produced through arti cial insemination (AI) with CF-C 60 -preserved sperm Reproductive performance is an important basis for evaluation of sperm quality [44]. Therefore, we conducted an AI experiment to evaluate the safety and e cacy of CF-C 60 as a semen diluent.…”

Section: Antibacterial Effect Of Cf-c 60 Mediated By Its Effect On Ro...mentioning

confidence: 99%

Carboxyfullerene C60 preserves sperm by enhancing antioxidant capacity and inhibiting apoptosis and harmful bacteria

Li,

Zhang,

Xiao

et al. 2024

Preprint

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Background The current approaches for the preservation of human sperm have several limitations, and there are a lack of effective non-freezing preservation methods. Recently, carboxyfullerene C60 (CF-C60) has gained attention as an important nanocarbon derivative with strong antioxidant and antibacterial activity. This study uses a porcine model to systematically investigate whether CF-C60 can be used for the preservation of sperm. Results The results indicate that CF-C60 supplementation can preserve sperm quality during storage at 17°C. This effect is attributable to improvement in the antioxidant capacity of sperm through a decrease in the ROS level. Additionally, CF-C60 can maintain mitochondrial function, inhibit sperm apoptosis through the ROS/Cytochrome C/Caspase 3 signaling pathway, and mediate suppression of bacterial growth through the effects of ROS. Finally, the results of artificial insemination experiments indicate that insemination with CF-C60-treated sperm can increase the total number of offspring born and reduce the number of deformed piglets. Conclusions Thus, CF-C60 can preserve sperm quality by inhibition of apoptosis and bacterial growth via a reduction in ROS levels and is safe for use as a component of semen diluent for storage. These findings pave the way for the prospective clinical application of carbon nano-materials as antioxidants for non-freezing sperm preservation methods.

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“…Bu sorunların en önemlileri: İnfertilite, cinsel yolla bulaşan hastalıklar, cinsel işlev bozuklukları, ürogenital anomaliler, prostat bezi hastalıkları, andropoz. (Bertolla, 2020;Sade vd., 2019;Tharakan vd., 2020).…”

Section: Erkeklerde üReme Sağliğiunclassified

Sağlık Bilimlerinde Akademik Analiz ve Tartışmalar

2023

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Sağlık Bilimi, toplum, kamu ve özel kuruluşlar, topluluk ve bireyler tarafından yapılan çabalar ve seçimler yoluyla hastalıkları önleme, yaşam süresini uzatma ve sağlığı geliştirme sanatıdır. Sağlık Bilimi, hastalıkları ve diğer fiziksel ve zihinsel sağlık koşullarını tespit edip önleyerek, sağlık davranışlarını teşvik ederek, vakaları ve sağlık göstergelerini izleyerek sağlık kalitesini ve yaşam kalitesini iyileştirmek için küçük veya büyük bir nüfusun (yani bir kıtanın nüfusu) halk sağlığına yönelik tehlikelerle ilgilenir. Diğer yandan, epidemiyoloji, biyoistatistik ve sağlık hizmetlerini içeren çok disiplinli bir yöntem kullanır. Bu kitapta sağlık bilimleri incelenmiştir.

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Sperm biology and male reproductive health

Cited by 17 publications

References 19 publications

Analysis of copy number variations of the autosomal genome in 156 patients with azoospermia

Analysis of copy number variations of the autosomal genome in 156 patients with azoospermia

Carboxyfullerene C60 preserves sperm by enhancing antioxidant capacity and inhibiting apoptosis and harmful bacteria

Sağlık Bilimlerinde Akademik Analiz ve Tartışmalar

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