Sperm cryopreservation and assisted reproductive technology outcome in patients with spinal cord injury

Reignier, Arnaud; Lammers, Jenna; Splingart, Carole; Redhead, Doris N.; Labat, J.-J.; Mirallié, S.; Barrière, P.; Fréour, Thomas

doi:10.1111/and.12833

Cited by 13 publications

(7 citation statements)

References 24 publications

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“…It is obvious that patients diagnosed with cancers in the reproductive age (mostly testicular cancers and lymphomas) are the primary recipients for sperm cryopreservation [ 52 – 56 ]. Furthermore, the andrologist may suggest sperm cryopreservation whenever it may facilitate ART procedures, such as the cases of patients with spinal cord injury [ 57 , 58 ] and of those with severe alteration of spermatogenesis risking high fluctuations of semen quality [ 59 ]. In the latter case, in the presence of severe OAT, fluctuations may result in azoospermia, either transient or permanent.…”

Section: Fertility Preservation and Art—oncofertilitymentioning

confidence: 99%

The impact of male factors and their correct and early diagnosis in the infertile couple's pathway: 2021 perspectives

Pallotti

Barbonetti

Rastrelli

et al. 2022

J Endocrinol Invest

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Purpose The current clinical practice in reproductive medicine should pose the couple at the centre of the diagnostic–therapeutic management of infertility and requires intense collaboration between the andrologist, the gynaecologist and the embryologist. The andrologist, in particular, to adequately support the infertile couple, must undertake important biological, psychological, economical and ethical task. Thus, this paper aims to provide a comprehensive overview of the multifaceted role of the andrologist in the study of male factor infertility. Methods A comprehensive Medline, Embase and Cochrane search was performed including publications between 1969 and 2021. Results Available evidence indicates that a careful medical history and physical examination, followed by semen analysis, always represent the basic starting points of the diagnostic work up in male partner of an infertile couple. Regarding treatment, gonadotropins are an effective treatment in case of hypogonadotropic hypogonadism and FSH may be used in men with idiopathic infertility, while evidence supporting other hormonal and nonhormonal treatments is either limited or conflicting. In the future, pharmacogenomics of FSHR and FSHB as well as innovative compounds may be considered to develop new therapeutic strategies in the management of infertility. Conclusion To provide a high-level of care, the andrologist must face several critical diagnostical and therapeutical steps. Even though ART may be the final and decisive stage of this decisional network, neglecting to treat the male partner may ultimately increase the risks of negative outcome, as well as costs and psychological burden for the couple itself.

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Section: Fertility Preservation and Art—oncofertilitymentioning

confidence: 99%

The impact of male factors and their correct and early diagnosis in the infertile couple's pathway: 2021 perspectives

Pallotti

Barbonetti

Rastrelli

et al. 2022

J Endocrinol Invest

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“…2‐The sudden rise in pressure of the spinal cord may lead to reduced sperm number. Spinal SAH may be accepted as spinal cord injury (SCI), which usually results in loss of sensory, motor, and autonomic nerve function mostly involves males of parenting age (Reignier et al., 2018). As a result, infertility may occur (Yuan et al., 2017).…”

Section: Discussionmentioning

confidence: 99%

First emerging evidence of the relationship between Onuf’s nucleus degeneration and reduced sperm number following spinal subarachnoid haemorrhage: Experimental study

et al. 2021

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Lumbosacral pathologies can lead to infertility. Onuf's nucleus changes in these pathologies may have a role in low sperm number. This study aims to investigate the relationship between Onuf's nucleus degeneration and sperm number following spinal subarachnoid haemorrhage. 22 rabbits were used. They were divided into three groups; five of them were used as the control (GI), five as the SHAM (GII) and twelve as the study groups (GIII). The study group received 0.7 ccs autologous blood into the spinal subarachnoid space at the T12‐L1 level. After two weeks, all animals were decapitated, and S1–S3 laminectomy was done. Neurodegenerative changes of Onuf's nucleus, pudendal ganglia (S3) following two weeks after spinal SAH, were examined; sperm numbers were calculated. Degenerated neuron density of the Onuf's nucleus (n/mm3), the pudendal ganglia (S3) (n/mm3) and mean sperm numbers were calculated as 5 ± 2, 8 ± 3/mm3 and 98.345 ± 12.776/mm3 in the control (GI), 20 ± 5/mm3, 243 ± 66/mm3 and 91.841 ± 9.654/mm3 in the SHAM (GII), 143 ± 39/mm3, 2,350 ± 320/mm3 and 68.549 ± 5.540/mm3 in the study group (GIII). In conclusion, there were statistically significant differences between groups. Onuf's nucleus may be responsible for decreased sperm number following spinal SAH.

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“…75%) achieved by use of frozen/thawed sperm obtained after PVS or surgical sperm retrieval combined with ICSI ( 11 ). Furthermore, analysis of spinal cord injured patients’ semen parameters before and after cryopreservation revealed no differences in semen characteristics or in ART cycle results with frozen-thawed spermatozoa of SCL patients compared to the infertile population ( 57 ).…”

Section: Pregnancy Outcomementioning

confidence: 92%

Improvement of Sexual and Reproductive Function in Men with Spinal Cord Lesion

Kasum

Orešković

Kordić

et al. 2018

ACC

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SUMMARY – The aim of the review is to establish sexual and reproductive functions in men with spinal cord lesion (SCL). Many sexual and reproductive dysfunctions may be found in these patients including individual’s low self-esteem, delay of orgasm, erectile or ejaculatory disorder and abnormalities of semen, which are characterized by lower sperm motility or viability. Owing to improvements in physical medicine and rehabilitation, the focus has been shifted from keeping patients alive towards ensuring the quality of life and improvements of sexual dysfunctions and later reproduction. Erectile dysfunction can be treated by using phosphodiesterase-5 inhibitors, intracavernosal injections, vacuum devices and penile prostheses. Semen can be retrieved from anejaculatory patients by medically assisted methods utilizing penile vibratory stimulation, electroejaculation, prostate massage, or surgically. Although there is low chance for pregnancy in natural way in most of SCL patients, fatherhood is possible through the introduction of assisted medical management. By use of various medical, technical and surgical procedures for sperm retrieval combined with assisted reproductive methods, high pregnancy rates have been reported comparable to those in able-bodied subfertile patients. Nevertheless, future studies are needed to improve semen quality and methods of assisted ejaculation in patients with SCL.

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Sperm cryopreservation and assisted reproductive technology outcome in patients with spinal cord injury

Cited by 13 publications

References 24 publications

The impact of male factors and their correct and early diagnosis in the infertile couple's pathway: 2021 perspectives

The impact of male factors and their correct and early diagnosis in the infertile couple's pathway: 2021 perspectives

First emerging evidence of the relationship between Onuf’s nucleus degeneration and reduced sperm number following spinal subarachnoid haemorrhage: Experimental study

Improvement of Sexual and Reproductive Function in Men with Spinal Cord Lesion

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