Sperm cryopreservation before cancer chemotherapy helps in the emotional battle against cancer

Saito, Kazuo; Suzuki, Kotaro; Iwasaki, Akira; Yumura, Yasushi; Kubota, Yoshinobu

doi:10.1002/cncr.21185

Cited by 200 publications

(142 citation statements)

References 15 publications

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“…Instead, many patients are left with significant anxieties over reproductive health concerns (28). On the other hand, assuring a patient that his fertility potential is secured by sperm banking could help in the emotional battle against cancer (29).…”

Section: Commentsmentioning

confidence: 99%

Sperm banking for male cancer patients: social and semen profiles

et al. 2009

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Purpose: Report the characteristics of cryopreserved semen from a cohort of male cancer patients, attitudes towards cryopreservation and outcomes of semen samples based on a 12-year cryopreservation program. Material and Methods: Data from 98 male cancer patients whose sperm samples were banked were evaluated. Demographic parameters, semen characteristics, destination of sperm banked samples and questionnaires answered by the patients regarding cryopreservation time were evaluated. Results: The cancer diagnoses were testicle (56.1%), prostate (15.3%), Hodgkin's lymphomas (9.2%), non-Hodgkin's lymphomas (7.1%), leukemia (3.1%) and other malignancies (9.2%). The patients with testicular cancer presented lower sperm concentration (p < 0.001); however, there were no differences with the percentage of normozoospermic patients among cancer type groups (p = 0.185). A shorter time between cancer diagnosis and sperm banking was observed for testicular and prostate cancer patients (p < 0.001). Most of the patients (89.5%) favored sperm banking as a fertility preservation method. Conclusions: Although less than 20% of banked sperm samples were disposed of, the majority of patients related sperm banking with safe for fertility preservation. Our results show that all male cancer patients of reproductive age facing cancer treatment could be offered sperm banking.

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Section: Commentsmentioning

confidence: 99%

Sperm banking for male cancer patients: social and semen profiles

et al. 2009

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“…Sperm cryopreservation is also emotionally beneficial for patients. Saito et al (23) reported that sperm cryopreservation improved the psychological status of young cancer patients during and after cancer treatment. In our study, unmarried and childless patients aged >20 years expressed a positive attitude towards fertility preservation and did preserve their sperm prior to commencing cancer treatment, whereas patients who already had children did not wish to preserve their sperm, stating that they did not wish for more children.…”

Section: Discussionmentioning

confidence: 99%

“…This prospective study included a total of 14 male patients, aged <45 years at diagnosis, who were treated for high-grade malignant bone and soft tissue tumors at the Osaka City University Hospital (Osaka, Japan) between January, 2008 and December, 2013. The median age at diagnosis was 23 performed to obtain a histological diagnosis. All the biopsy specimens were examined by a pathologist specialized in sarcoma pathology and diagnosed according to the standard criteria for bone and soft tissue sarcoma subtyping (9).…”

Section: Methodsmentioning

confidence: 99%

Pre-chemotherapy preservation of fertility in male patients with high-grade malignant bone and soft tissue tumors

Hoshi

Oebisu

Takada

et al. 2014

Molecular and Clinical Oncology

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Abstract. Only a limited number of orthopedic oncologists make arrangements for pre-chemotherapy fertility preservation, such as sperm cryopreservation, for their patients. The purpose of this study was to offer fertility preservation to male patients with high-grade malignant bone and soft tissue tumors and assess the outcomes. The study included 14 male patients, aged <45 years, with high-grade bone and soft tissue tumors. The median age at diagnosis was 23.0±12.0 years (range, 8-42 years). Following pathological confirmation of high-grade malignant tumor, we informed all the patients and/or their guardians on the issue of chemotherapy-related male infertility. If the patients were interested in preserving fertility, they were referred to a team of reproductive specialists. We documented the patients' clinical characteristics and techniques used for fertility preservation. The majority of unmarried and childless patients were interested in fertility preservation. Four patients (28.5%) selected sperm cryopreservation and 1 patient (7.1%) selected hemi-testicular preservation, as he had developed erectile dysfunction following previous surgery for colon cancer. Married patients and those with children did not wish to preserve fertility. In conclusion, infertility following chemotherapy raises serious concerns for young male patients with high-grade bone and soft tissue tumors. Prior to initiating chemotherapy, the potential risks of chemotherapy should be explained, counseling should be provided and informed consent should be obtained from the patients, ideally without delaying commencement of cancer treatment. Prior to administering cancer chemotherapy, orthopedic oncologists are encouraged to offer sperm banking to young male patients at risk of infertility.

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“…3,9,14 Most of the existing data were collected retrospectively years after cancer treatment. 2,3,8,9,14,15 Retrospective design studies have limitations of recall bias. At present, very limited data are available on patients' perspectives at the time of sperm banking.…”

Section: Introductionmentioning

confidence: 99%

“Just what the doctor ordered”: Factors associated with oncology patients’ decision to bank sperm

Yee¹,

Fuller‐Thomson²,

Dwyer³

et al. 2012

CUAJ

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Introduction: The purpose of this cross-sectional study was to explore factors associated with oncology patients' decision to bank sperm prior to cancer treatment. Materials and Methods:Patients who were referred to the oncology sperm banking program between January 2009 and March 2010 were invited to complete an 18-item questionnaire during one of their sperm banking visits. Results: Of the 157 cancer patients referred to the Mount Sinai Oncology Sperm and Tissue Bank for sperm banking during the 15-month period, 79 questionnaires were returned (50% response rate). Of the respondents, 89% were informed about sperm banking by their physician. Future family planning was cited as the main reason to bank. Cost was not a barrier for the vast majority of respondents. Forty percent of respondents banked sperm within 4 days prior to initiating cancer treatment. Most respondents relied on their physician for verbal information on sperm banking. Eightyone percent were unaware of any patient organizations that have educational materials on oncology fertility preservation. Conclusion: Sperm banking prior to cancer treatment is the only proven method of preserving fertility for cancer patients. The two main determinants associated with deciding whether to bank sperm were: the physician's recommendation and the patient's desire for future fatherhood. Physicians play a key role in influencing patients' decisions. The recommendation to bank sperm is a persuasive message if patients are clearly informed about their potential risk of infertility post-cancer treatment, and that sperm banking is an effective way of preserving fertility. Providing patients with education materials might enhance compliance in sperm banking. RésuméIntroduction : Le but de cette étude transversale était d'explorer les facteurs influant sur la décision des patients atteints de cancer de mettre du sperme en banque avant un traitement anticancéreux. Matériel et méthodologie : Les patients qui ont été orientés vers le programme de conservation de sperme pour patients cancéreux entre janvier 2009 et mars 2010 ont été invités à remplir un questionnaire à 18 questions au cours d'une de leurs visites à la banque de sperme. Résultats :Sur les 157 patients cancéreux orientés vers la banque de sperme et de tissus du Mount Sinai Hospital pour la mise en banque de sperme durant la période de 15 mois, 79 ont retourné un questionnaire (taux de réponse de 50 %). De ces répondants, 89 % avaient reçu des informations sur la banque de sperme de la part de leur médecin. La planification familiale était mentionnée comme la principale raison d'utiliser la banque. Le coût n'était pas un obstacle pour la grande majorité des répondants. Quarante pour cent des répondants ont mis du sperme en banque dans les quatre jours précédant le début du traitement anticancéreux. La plupart des répondants avaient reçu des informations verbales de leur médecin sur la mise en banque de sperme. Quatre-vingt-un pour cent n'étaient pas au courant s'il existait des organisations de patie...

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Sperm cryopreservation before cancer chemotherapy helps in the emotional battle against cancer

Cited by 200 publications

References 15 publications

Sperm banking for male cancer patients: social and semen profiles

Sperm banking for male cancer patients: social and semen profiles

Pre-chemotherapy preservation of fertility in male patients with high-grade malignant bone and soft tissue tumors

“Just what the doctor ordered”: Factors associated with oncology patients’ decision to bank sperm

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