Sperm cryopreservation before cancer treatment: a 15-year monocentric experience

Bizet, P.; Saïas-Magnan, J.; Jouve, Élisabeth; Grillo, Jean-Marie; Karsenty, G.; Metzler‐Guillemain, Catherine; Perrin, Jeanne

doi:10.1016/j.rbmo.2011.11.015

Cited by 74 publications

(73 citation statements)

References 45 publications

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“…Although most studies comparing ICSI using fresh or thawed spermatozoa do not reveal differences in reproductive outcome (18,19), it appears that ICSI performed with motile spermatozoa gives better results with respect to immotile ones (20,21). As a matter of fact, ICSI performed using cryopreserved spermatozoa from patients with different types of cancer or pathologies gives rise to variable clinical pregnancy and live-birth rates (12,22). Owing to the detrimental effects of cryopreservation, the chance of finding motile sperm after thawing to perform the ICSI procedure is greatly decreased.…”

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confidence: 99%

Semen cryopreservation for men banking for oligospermia, cancers, and other pathologies: prediction of post-thaw outcome using basal semen quality

Degl'Innocenti

Filimberti

Magini

et al. 2013

Fertility and Sterility

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Objective: To evaluate post-thawing sperm parameters in a large series of men cryopreserving for different cancers and oligospermia. Design: Retrospective observational study. Setting: Semen cryopreservation laboratory. Patient(s): Six hundred twenty-three patients undergoing semen cryopreservation for cancer or oligospermia who discontinued banking. Intervention(s): None. Main Outcome Measure(s): Postcryopreservation sperm motility and viability. Result(s): In oligospermic men, recovery of motile sperm after cryopreservation was possible in only a few out of the 219 samples cryopreserved for this problem. Similarly, independent of the reason for which cryopreservation was required, if one basal semen parameter fell below the 5th percentile of the World Health Organization reference values, recovery of motile and viable spermatozoa after thawing was low. Among samples cryopreserved for cancer, those with testicular cancer showed the lowest basal semen quality and recovery after thawing. In cases of hematological cancers or other types of cancers, motility recovery was similar to that of non-cancerrelated samples. Receiver operating characteristic analyses demonstrate that basal progressive and total motility predict the recovery rate of motile sperm after thawing with high accuracy, sensibility and specificity. Conclusion(s): Our study demonstrates the ability of prefreeze semen parameters to predict cryosurvival in terms of sensitivity and precision. Using this information, the clinician could perform appropriate counseling about the future possibilities of fertility for the patient. (Fertil Steril Ò 2013;100:1555-63.

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confidence: 99%

Semen cryopreservation for men banking for oligospermia, cancers, and other pathologies: prediction of post-thaw outcome using basal semen quality

Degl'Innocenti

Filimberti

Magini

et al. 2013

Fertility and Sterility

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“…Örneğin TK'lı erkeklerde tedavi öncesi sperm sayılarının diğer kanser tanısı konulan erkeklere oranla anlamlı olarak düşük olduğu tespit edilmiştir (9). Buna ek olarak kanser tedavisi için kullanılan cerrahi yöntemler, kemoterapi ve radyoterapide spermatogenezi olumsuz etkilemektedir (10) (Tablo 1'de testis üzerine etkili radyoterapi ve kemoterapi tedavi protokolleri özetlenmiştir).…”

Section: Malignitenin Fertilite üZerine Etkisiunclassified

Testis Kanserli Hastalarda Sperm Dondurma ve İnfertilite

Bakircioglu¹,

Alıcı²

2014

uob

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Güncel kanser tedavileri ile genç erkeklerin yaşam süreleri uzamasına karşın kullanılan kemoterapi ve radyoterapi infertiliteye neden olabilmektedir. Bu derlemede amacımız testis kanserli erkeklerde fertilite potansiyelinin tedavi öncesinde ve sonrasında korunması hakkında literatür bilgilerini incelemektir. Testis kanserli erkeklerde sperm konsantrasyonları diğer kanser tiplerine göre daha düşük olduğu tespit edilmiştir. Tedavi için kullanılan kemoterapi ve radyoterapi spermatogenezi negatif olarak etkilemektedir. Buna rağmen kemoterapi gören erkeklerin sperm parametreleri 1 yıl sonra, radyoterapi görenlerde ise 2 yıl sonra tedavi öncesi değerlere geri dönebilir. Erkeklerde tedavi öncesinde azoospermi görüldüğü durumlarda orşiektomi ile eş zamanlı testisten sperm elde ederek (TESE) sperm saklama uygulanabilir. Sperm dondurma kanser hastalarında fertilite potansiyelinin korunması için hala altın standarttır. Bu nedenle testis kanseri teşhis edilen erkeklerin tedavilerine başlamadan önce mevcut potansiyellerinin anlaşılması ve sperm dondurma işlemi için infertilite merkezlerine başvurmaları desteklenmelidir. (Üroonkoloji Bülteni 2014;13:176-181) Anah tar Ke li me ler: Testis kanseri, sperm dondurma, infertilite Modern cancer therapies have greatly improved survival rates in men of reproductive age and younger; however, surgery, chemotherapy and radiation therapy may lead to male infertility. In this review, we would like to investigate fertility status of men with testicular cancer and sperm preservation options before and after cancer treatment. Sperm concentration of patients diagnosed with testicular cancer is lower than other cancer patients. In addition to that chemotherapy and radiotherapy negatively affect spermatogenesis. Radiotherapy have a much more deleterious effect on fertility compared with chemotherapy alone. However, after one year of chemotherapy or two years of radiotherapy, semen parameters may return to basal levels before cancer therapy. If the patient is azoospermic before any cancer specific treatment, testicular sperm extraction (TESE) for cryopreservation is an option at the time with orchiectomy operation. Sperm cryopreservation is still a gold standard to preserve fertility potential for cancer patients before the cancer specific treatments. Therefore, men diagnosed with testicular cancer should be encouraged to contact with infertility clinics to understand their fertility potentials and for sperm cryopreservation. (Bulletin of Urooncology 2014;13:176-181)

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“…Similarly, oncologists propose sperm banking to all young cancer patients before chemotherapy, although it has been shown that more than 70% of cancer patients recover spermatogenesis after cancer treatment and that the use rate of banked sperm is very low (6%) [34][35][36].…”

Section: Sperm Cryopreservation Is Affordable and Simple In Specialismentioning

confidence: 99%

Should sperm be cryopreserved after spinal cord injury?

Karsenty

Bernuz

Metzler‐Guillemain

et al. 2013

Basic Clin. Androl.

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In spinal cord injured (SCI) patients, three main factors may cause infertility: erectile dysfunction, ejaculatory dysfunction and impaired semen quality. This letter aims to discuss how we can manage SCI patients' fertility in accordance with patient-centred care. For such SCI patients aged 20 to 40, having children represents hope for the future. Furthermore, it is a way to rebuild a life after the spinal injury and must be seen as an important part of the rehabilitation program. We suggest that sperm cryopreservation may contribute to patient-centred care management of SCI patients' fertility, although there is no scientific evidence that cryopreservation will improve fertility outcome after SCI. Indeed, sperm cryopreservation is an affordable and simple technique in specialised centres with trained staff. Here, a protocol to manage SCI patients' fertility is discussed: we propose PVS for sperm banking to all SCI patients after the phase of spinal shock during the rehabilitation program. If live sperm are retrieved, they are frozen and stored; however, if no live sperm are retrieved, electroejaculation and/or surgical sperm extraction are proposed only for patients who desire biological fatherhood. Prospective studies on the evolution of semen parameters, ejaculatory dysfunction, post-infectious obstructions and spermatogenesis impairment in chronic SCI patients are urgently needed to provide robust data for the evidence-based management of SCI patients' fertility. Even if use rates are expected to be low, sperm banking may be a simple and affordable preventative measure for selected male SCI patients.Keywords: Spinal cord injury, Fertility preservation, Sperm banking, Semen parameters, Spermatogenesis RésuméChez les patients blessés médullaires (BM), trois facteurs principaux peuvent provoquer une infertilité : la dysfonction érectile, la dyséjaculation et l'altération des paramètres spermatiques. Cette lettre a pour but de discuter comment gérer la fertilité des BM en accord avec le principe de soins axés sur le patient. Pour ces patients principalement âgés de 20 à 40 ans, la paternité représente un espoir pour le futur et un moyen de se reconstruire après la lésion médullaire ; cet aspect doit être considéré comme une partie importante du programme de réhabilitation. Nous suggérons que la cryoconservation de sperme (CS) chez le BM pourrait contribuer au principe de soins axés sur le patient, bien qu'il n'y ait pas de preuve scientifique que la CS améliore les résultats en assistance médicale à la procréation. En effet, la CS est une technique abordable et simple dans les centres spécialisés au personnel entraîné. Un protocole de prise en charge de la fertilité du BM est discuté : nous proposons la stimulation vibratoire pénienne à tous les patients BM après la phase de choc spinal, au cours du séjour en rééducation fonctionnelle. Si des spermatozoïdes sont obtenus dans l'éjaculat, ils sont cryoconservés ; dans le cas contraire, nous proposons une électroéjaculation et/ou un prélèvement chirurgical...

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Sperm cryopreservation before cancer treatment: a 15-year monocentric experience

Cited by 74 publications

References 45 publications

Semen cryopreservation for men banking for oligospermia, cancers, and other pathologies: prediction of post-thaw outcome using basal semen quality

Semen cryopreservation for men banking for oligospermia, cancers, and other pathologies: prediction of post-thaw outcome using basal semen quality

Testis Kanserli Hastalarda Sperm Dondurma ve İnfertilite

Should sperm be cryopreserved after spinal cord injury?

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