Sperm DNA Damage in Cancer Patients

Beaud, Hermance; Tremblay, Amélie; Chan, Peter; Delbès, Géraldine

doi:10.1007/978-3-030-21664-1_11

Cited by 20 publications

(11 citation statements)

References 125 publications

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“…It is therefore important to pursue research programs to decipher the underlying molecular mechanisms to improve cancer treatments while minimizing their long‐term side effects, particularly on fertility. This is a public health issue, because with advances in the effectiveness of cancer treatments, patient survival rates have increased, [ 55 , 56 ] and it is estimated that 1 in 530 young adults aged 20 to 40 years is a cancer survivor; [ 57 ] this relative number is expected to increase in the coming decades.…”

Section: Discussionmentioning

confidence: 99%

Identification of a Crosstalk among TGR5, GLIS2, and TP53 Signaling Pathways in the Control of Undifferentiated Germ Cell Homeostasis and Chemoresistance

et al. 2022

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Spermatogonial stem cells regenerate and maintain spermatogenesis throughout life, making testis a good model for studying stem cell biology. The effects of chemotherapy on fertility have been well‐documented previously. This study investigates how busulfan, an alkylating agent that is often used for chemotherapeutic purposes, affects male fertility. Specifically, the role of the TGR5 pathway is investigated on spermatogonia homeostasis using in vivo, in vitro, and pharmacological methods. In vivo studies are performed using wild‐type and Tgr5‐deficient mouse models. The results clearly show that Tgr5 deficiency can facilitate restoration of the spermatogonia homeostasis and allow faster resurgence of germ cell lineage after exposure to busulfan. TGR5 modulates the expression of key genes of undifferentiated spermatogonia such as Gfra1 and Fgfr2. At the molecular level, the present data highlight molecular mechanisms underlying the interactions among the TGR5, GLIS2, and TP53 pathways in spermatogonia associated with germ cell apoptosis following busulfan exposure. This study makes a significant contribution to the literature because it shows that TGR5 plays key role on undifferentiated germ cell homeostasis and that modulating the TGR5 signaling pathway could be used as a potential therapeutic tool for fertility disorders.

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Section: Discussionmentioning

confidence: 99%

Identification of a Crosstalk among TGR5, GLIS2, and TP53 Signaling Pathways in the Control of Undifferentiated Germ Cell Homeostasis and Chemoresistance

et al. 2022

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“…Normal reproductive outcomes have been documented with thawed semen collected during therapy but before azoospermia. 12,19,47 In a small study of 66 patients with postchemotherapy azoospermia, microsurgical testicular sperm extraction with intracytoplasmic sperm injection resulted in a live birth rate of 27% with no resultant birth defects. 48 These studies suggest that assisted conception using postchemotherapy sperm may be an option for these men.…”

Section: Risks Of Using Post-treatment Spermmentioning

confidence: 99%

“…9,17,18 Many oncologists and patients often do not consider sperm cryopreservation until after the cancer treatment has begun. 19…”

mentioning

confidence: 99%

Current Gaps in Fertility Preservation for Men: How Can We do Better?

Ghidei

Sullivan

Carrion

et al. 2022

JCO

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Ghidei et al present a discussion surrounding the importance of male fertility preservation for patients with cancer. Fertility preservation is an increasingly important component of survivorship. Guidelines from American Society of Clinical Oncology recommend that providers address the possibility of infertility with patients who are undergoing treatment as early as possible. However, timely sperm banking has been strikingly underutilized. Semen cryopreservation is a proven and feasible method for preserving fertility. As gonadal function may be impaired soon after treatment has begun, men are encouraged to bank sperm before starting treatment to optimize their future reproductive opportunities.

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“…In rats, the administration of CHOP leads to a reduction in sperm count and sperm recovery has been observed nine weeks after treatment or the equivalent of more than one spermatogenesis cycle [112]. However, the recovery of a normal sperm count does not guarantee an intact sperm nuclear quality [113].…”

Section: Sperm Production and Recovery Periodmentioning

confidence: 99%

Exposure to Chemotherapy During Childhood or Adulthood and Consequences on Spermatogenesis and Male Fertility

Delessard

Saulnier

Rives

et al. 2020

IJMS

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Over the last decade, the number of cancer survivors has increased thanks to progress in diagnosis and treatment. Cancer treatments are often accompanied by adverse side effects depending on the age of the patient, the type of cancer, the treatment regimen, and the doses. The testicular tissue is very sensitive to chemotherapy and radiotherapy. This review will summarize the epidemiological and experimental data concerning the consequences of exposure to chemotherapy during the prepubertal period or adulthood on spermatogenic progression, sperm production, sperm nuclear quality, and the health of the offspring. Studies concerning the gonadotoxicity of anticancer drugs in adult survivors of childhood cancer are still limited compared with those concerning the effects of chemotherapy exposure during adulthood. In humans, it is difficult to evaluate exactly the toxicity of chemotherapeutic agents because cancer treatments often combine chemotherapy and radiotherapy. Thus, it is important to undertake experimental studies in animal models in order to define the mechanism involved in the drug gonadotoxicity and to assess the effects of their administration alone or in combination on immature and mature testis. These data will help to better inform cancer patients after recovery about the risks of chemotherapy for their future fertility and to propose fertility preservation options.

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Sperm DNA Damage in Cancer Patients

Cited by 20 publications

References 125 publications

Identification of a Crosstalk among TGR5, GLIS2, and TP53 Signaling Pathways in the Control of Undifferentiated Germ Cell Homeostasis and Chemoresistance

Identification of a Crosstalk among TGR5, GLIS2, and TP53 Signaling Pathways in the Control of Undifferentiated Germ Cell Homeostasis and Chemoresistance

Current Gaps in Fertility Preservation for Men: How Can We do Better?

Exposure to Chemotherapy During Childhood or Adulthood and Consequences on Spermatogenesis and Male Fertility

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