Sperm DNA Fragmentation and Male Infertility

Selvam, Manesh Kumar Panner; Sengupta, Pallav; Agarwal, Ashok

doi:10.1007/978-3-030-37972-8_9

Cited by 29 publications

(11 citation statements)

References 96 publications

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“…In fact, new devices for diagnosis are developed based on the novel data produced by the scientific community, such as computer-assisted semen analysis (CASA) systems, analysis of the DNA damage, accessing sperm telomere length or the adoption of stricter criteria for sperm morphology evaluation (Jeyendran, Caroppo, Rouen, Anderson, & Puscheck, 2019;Lopes, Oliveira, & Sousa, 2019). In particular, assays for analysing sperm DNA integrity have been extensively investigated over the past de-cade (Majzoub, Arafa, Elbardisi, & Agarwal, 2020;Panner Selvam, Sengupta, & Agarwal, 2020). Sperm DNA integrity is essential for fertilisation and early stages of the embryo development (Agarwal & Said, 2003).…”

Section: S Tandard S Emen Analys Ismentioning

confidence: 99%

Sperm selection strategies and their impact on assisted reproductive technology outcomes

et al. 2020

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Assisted reproductive technologies (ART) revolutionised human fertility by providing treatment to patients previously considered incapable for reproductive purposes (Henkel & Schill, 2003). In 2017, it was estimated that approximately 6 million infants were born through ART since 1978, when the first baby produced by in vitro fertilisation (IVF) was born. It has been reported that about half of these births were in the past decade, highlighting the increasing use of these technologies, (Hunter, 2017). Initially, ART research was mainly focused on comprehending the factors that increase the likelihood of a successful pregnancy and

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Section: S Tandard S Emen Analys Ismentioning

confidence: 99%

Sperm selection strategies and their impact on assisted reproductive technology outcomes

et al. 2020

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“…In the meanwhile, dysfunctional mitochondria produce less adenosine triphosphate levels which can inhibit the progression of stem cell precursors during the cell cycle, leading to hypospermatogenesis or maturation arrest [ 67 ]. These OS-induced damages, especially sperm DNA fragmentation may adversely affect reproductive outcomes because the inherent integrity of DNA determines the success rate of fertilization and embryonic development [ 68 ]. Generally speaking, DNA fragmentation index <30% is considered a necessary prerequisite for optimal fertility.…”

Section: Possible Mechanisms Of Covid-19 Affecting Male Reproductionmentioning

confidence: 99%

Effect of COVID-19 on sperm parameters: pathologic alterations and underlying mechanisms

Leng

Guo

Sang

et al. 2023

J Assist Reprod Genet

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The rapid outbreak of the coronavirus disease 2019 (COVID-19) pandemic has brought challenges to different medical fields, especially reproductive health. To date, most studies on the effects of COVID-19 on male reproduction have some limitations. In addition, there is little research on the mechanisms underlying by which severe acute respiratory syndrome coronavirus 2 infection affects semen quality. Here, we revealed the possible impact of COVID-19 on sperm parameters and the potential mechanisms. At present, it is still controversial whether COVID-19-induced fever adversely affects sperm parameters. Severe acute respiratory syndrome coronavirus 2 can induce up-regulation of pro-inflammatory cytokine, which leads to the destruction of blood-testis barrier and impairment of spermatogenesis. Moreover, severe viral infection of the respiratory system could induce systemic oxidative stress. Sperm are highly vulnerable to it due to their limited levels of antioxidant defense, unsophisticated DNA damage detection and repair mechanisms. Our review prompt medical staff and patients to consciously check the reproductive function of COVID-19 male patients. Moreover, opening our prospective beyond the direct infection could be the key to better understand the COVID-19 short and long-term effects and provide a new idea for future treatment of patients with reproductive function injury.

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“…Reports claim that obesity-induced altered testosterone production, spermatogenesis and semen quality may be carried out via some common mechanisms that involve OS (Sengupta et al, 2019a). The membranes of the sperm cells are rich in polyunsaturated fatty acid that predisposes them to reactive oxygen species (ROS) attack and oxidative damage including damaged sperm DNA integrity (Selvam et al, 2020). It is credible to suggest that irisin-induced activation of Nrf2 via upregulation of p38 MAPK and ERK signaling (Zhao et al, 2014) may confer protection against ROS attack and oxidative damage to the testis and the sperm cells, thereby enhancing spermatogenesis and sperm quality (Figure 2).…”

Section: Irisin Spermatogenesis and Sperm Qualitymentioning

confidence: 99%

Irisin, Energy Homeostasis and Male Reproduction

et al. 2021

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Irisin is a novel skeletal muscle- and adipose tissue-secreted peptide. It is conventionally regarded as an adipomyokine and is a cleaved fragment of Fibronectin type III domain-containing protein 5 (FNDC5). It is involved in the browning of white adipose tissue, glucose tolerance, and reversing of metabolic disruptions. Fertility is closely linked to energy metabolism and the endocrine function of the adipose tissue. Moreover, there is established association between obesity and male infertility. Irisin bears strong therapeutic promise in obesity and its associated disorders, as well as shown to improve male reproductive functions. Thus, irisin is a molecule of great interest in exploring the amelioration of metabolic syndrome or obesity-induced male infertility. In this review we aim to enumerate the most significant aspects of irisin actions and discuss its involvement in energy homeostasis and male reproduction. Though current and future research on irisin is very promiscuous, a number of clarifications are still needed to reveal its full potential as a significant medicinal target in several human diseases including male infertility.

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Sperm DNA Fragmentation and Male Infertility

Cited by 29 publications

References 96 publications

Sperm selection strategies and their impact on assisted reproductive technology outcomes

Sperm selection strategies and their impact on assisted reproductive technology outcomes

Effect of COVID-19 on sperm parameters: pathologic alterations and underlying mechanisms

Irisin, Energy Homeostasis and Male Reproduction

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