Sperm DNA fragmentation index with unexplained recurrent spontaneous abortion: A systematic review and meta-analysis

Pu, Yifu; Yan, Lei; Lu, Shaoming; Guo, Yanjie; Zhu, Xing-Wang

doi:10.1016/j.jogoh.2020.101740

Cited by 33 publications

(31 citation statements)

References 18 publications

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“…Furthermore, males with high DFI and Comet scores have reduced fertilization rates, embryo quality and pregnancy outcomes from IVF (Haddock et al, 2021; Simon et al, 2011; Virro et al, 2004) and ICSI (Simon et al, 2010; Virro et al, 2004). SCSA and Comet are also valuable in predicting miscarriage (Evenson et al, 1999; Yifu et al, 2020) and live birth rates (Osman et al, 2015). Hence, via generation of OS and DNA damage, male GM may play a much wider role in infertility than previously thought.…”

Section: Discussionmentioning

confidence: 99%

The relationship between genitourinary microorganisms and oxidative stress, sperm DNA fragmentation and semen parameters in infertile men

Vaughan-Constable

Ramsay

et al. 2021

Andrologia

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An imbalance in the genitourinary microbiome is emerging as a contributing factor to male infertility. The purpose of this study was to determine whether there is an association between genitourinary microorganisms and seminal oxidative stress, sperm DNA fragmentation and semen parameters. It included 770 men attending for diagnostic testing for subfertility. Genitourinary microorganisms were identified in 43.0% men; 20.1% had microorganisms in semen; 18.7% in urine; and 5.8% had microorganisms in urine and semen. Enterococcus faecalis was the most prevalent organism in semen (22.0% samples; 61.5% organisms) with Ureaplasma spp. (16.9% samples; 53.3% organisms) and Gardnerella vaginalis (11.4% samples; 37.4% organisms) most prevalent in urine. Semen parameters were unaffected by microorganisms (p > 0.05). Seminal ROS were significantly higher in men with microorganisms compared to those without (p < 0.001), particularly when present in both urine and semen (p < 0.01). Microorganisms were associated with significantly higher DNA fragmentation, irrespective of whether they were in semen or urine (p < 0.001). An imbalance in the genitourinary microbiome is associated with DNA damage and oxidative stress which may have considerable consequences for achieving an ongoing pregnancy. This highlights the need for incorporating genitourinary microorganism screening for all men as part of diagnostic evaluation prior to undergoing treatment for infertility.

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Section: Discussionmentioning

confidence: 99%

The relationship between genitourinary microorganisms and oxidative stress, sperm DNA fragmentation and semen parameters in infertile men

Vaughan-Constable

Ramsay

et al. 2021

Andrologia

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“…Thus, various aspects of aging, multiple stress factors, and negative factors affecting the DFI require further investigations (21). In terms of the link with IVF outcomes, it has been reported that, although there is no difference in the fertilization rate and embryonic development rate between high DFI and low DFI (22), a high DFI tends to be associated with higher rates of miscarriage, resulting in a low live birth rate per transplantation (23,24). The patients who underwent DFI analysis in this study provided semen samples before IVF treatment.…”

Section: Discussionmentioning

confidence: 99%

Correlation Between Semen Examination Based on the WHO Criteria and Sperm DNA Fragmentation Test

Okubo

Onda

Hayashi

et al. 2021

Preprint

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Purpose: We performed and analyzed the DFI test and semen test based on the WHO criteria and compared the two using semen factors. Methods: DFI tests and general semen tests were conducted in accordance with the WHO criteria, and correlations between the two tests were investigated. The WHO criteria were set as the cutoff value for each of the following factors: fluid volume, concentration, motility, and normal morphology, and compared with the DFI results.Results: The subjects had a mean DFI of 15.6±11.5% and the DFI increased with age. In contrast, the concentration, motility, and normal morphology decreased as the DFI increased. Patients who satisfied the WHO criteria in terms of sperm concentration, motility, and normal morphology had a significantly lower DFI than the group that did not satisfy the criteria. Therefore, evaluation with a general semen test based on the WHO criteria should be regarded as a qualitative evaluation of all factors other than fluid volume.Conclusions: Male infertility due to sperm DNA fragmentation should be suspected when in vitro fertilization (IVF) results are poor despite normal semen findings based on the WHO criteria. The results of this study suggest that the DFI test may be an important evaluation in follow-up semen analyses.

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“…Three meta-analyses [58][59][60] have demonstrated an association between an abnormal SDF and an increased miscarriage rate in couples undergoing ARTs. Table 4 shows the three meta-analyses investigating the effect of SDF on RPL [61][62][63]. Contemporary literature (Table 4) has reported that the male partner in couples with RPL have higher SDF levels than fertile controls.…”

Section: Recurrent Pregnancy Lossmentioning

confidence: 99%

European Association of Urology Guidelines Panel on Male Sexual and Reproductive Health: A Clinical Consultation Guide on the Indications for Performing Sperm DNA Fragmentation Testing in Men with Infertility and Testicular Sperm Extraction in Nonazoospermic Men

Tharakan

Bettocchi

Carvalho

et al. 2022

European Urology Focus

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Sperm DNA fragmentation index with unexplained recurrent spontaneous abortion: A systematic review and meta-analysis

Cited by 33 publications

References 18 publications

The relationship between genitourinary microorganisms and oxidative stress, sperm DNA fragmentation and semen parameters in infertile men

The relationship between genitourinary microorganisms and oxidative stress, sperm DNA fragmentation and semen parameters in infertile men

Correlation Between Semen Examination Based on the WHO Criteria and Sperm DNA Fragmentation Test

European Association of Urology Guidelines Panel on Male Sexual and Reproductive Health: A Clinical Consultation Guide on the Indications for Performing Sperm DNA Fragmentation Testing in Men with Infertility and Testicular Sperm Extraction in Nonazoospermic Men

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