Sperm Parameters Before and After COVID-19 mRNA Vaccination

González, Daniel; Nassau, Daniel E.; Khodamoradi, Kajal; Ibrahim, Emad; Blachman‐Braun, Ruben; Ory, Jesse; Ramasamy, Ranjith

doi:10.1001/jama.2021.9976

Cited by 147 publications

(174 citation statements)

References 6 publications

Supporting

Mentioning

148

Contrasting

Unclassified

Order By: Relevance

“…No differences were observed between the IVF treatment variables, number of oocytes, fertilization rate, or semen analyses. Moreover, a recently published research letter by Gonzales et al found no significant decreases in any sperm parameter following 2 doses of Covid-19 MRNA vaccine in 45 men (Gonzalez et al, 2021). We found no other study which investigated the association between SARS-CoV-2 vaccinations and male fertility.…”

Section: Discussioncontrasting

confidence: 51%

Does mRNA SARS-CoV-2 vaccine detrimentally affect male fertility, as reflected by semen analysis?

Lifshitz

Haas

Lebovitz

et al. 2022

Reproductive BioMedicine Online

View full text Add to dashboard Cite

Research question Does Pfizer's Covid-19 vaccination detrimentally affect semen analysis parameters? Design We conducted a prospective cohort study in a single large tertiary center in Israel between February and March of 2021. Semen samples of 75 fertile men were analyzed 1-2 months following the second dose of Pfizer's covid-19 vaccine. The semen parameters were compared to the WHO reference ranges. The primary outcome was the percentage of abnormal semen parameters in those vaccinated, i.e. the rates of oligozoospermia, reduced percentage of motile sperm and abnormal sperm morphology. Results The interval from the time of the second vaccine to the date of participation was on average 37 days, with most subjects describing either mild or no side effects after the first or second dose. The mean sperm concentration was 63.2±33.6 10^6 ml with only a single subject (1.3%) with sperm count of 12.5 10^6 ml, considered by the WHO as oligozoospermic. The mean sperm motility percentage was 64.5%±16.7 with only a single subject (1.3%) displaying reduced motility. No significant morphological abnormalities were observed. This constituted a significantly lower percentage of abnormal semen parameters compared with the 5% rates reported in fertile men by the WHO. Conclusions The semen parameters following Covid-19 vaccination were predominantly within normal reference ranges as set by the WHO and do not reflect any causative detrimental effect from COVID-19 vaccination. Our results strengthen the notion that the Pfizer's SARS-CoV-2 vaccine is safe and should be recommended to fertility seeking men. ClinicalTrials.gov number, NCT04778033.

show abstract

Section: Discussioncontrasting

confidence: 51%

Does mRNA SARS-CoV-2 vaccine detrimentally affect male fertility, as reflected by semen analysis?

Lifshitz

Haas

Lebovitz

et al. 2022

Reproductive BioMedicine Online

View full text Add to dashboard Cite

show abstract

“…In a very recent study of sperm parameters before and after 2 doses of a COVID-19 mRNA vaccine, there were no significant decreases in any sperm parameter among this small cohort of healthy men [ 4 ]. Because the vaccines contain mRNA and not the live virus, it is unlikely that the vaccine would affect sperm parameters.…”

Section: Covid Vaccines and Fertilitymentioning

confidence: 99%

“…Two recent 2021 studies show the COVID-19 vaccine has no impact on male or female reproductive potential. University of Miami’s study [ 4 ] was published as a Letter to the Editor on June 17, 2021, in the Journal of the American Medical Association which shows the COVID-19 vaccine does not affect sperm count. In addition, Fertility and Sterility published a study in July 2021 [ 5 ] that concluded the COVID-19 vaccine does not result in female sterility.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, Fertility and Sterility published a study in July 2021 [ 5 ] that concluded the COVID-19 vaccine does not result in female sterility. Both studies should reassure the public about the safety of the mRNA American technology COVID-19 vaccine [ 4 , 5 ]. ASRM maintains its position and guidelines that vaccination is the best way to avoid getting or transferring the COVID-19 coronavirus and should not dissuade anyone from building or adding to their family [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Will Procreation Ever Be The Same After COVID-19?

Allahbadia

2021

J Obstet Gynecol India

View full text Add to dashboard Cite

Medically assisted procreation will never be the same again after this China Virus epidemic. With billions of lives being affected by this damaging global pandemic, medically assisted procreation services were not left unharmed with far-reaching consequences. New challenges are now emerging concerning COVID-19, such as associated reproductive implications and the consequences of assisted and natural procreation in the presence of acute SARS-CoV-2 infection and delayed consequences after patient recovery. There is a hypothesis that testicular damage and subsequent infertility may result following COVID-19 infection and the possibility of sexual transmission, as SARS-CoV-2 has been identified in the semen of infected patients. Vaccine hesitancy in young women planning pregnancies has been heightened because of the spread of misinformation on social media stating that COVID-19 vaccines will cause sterility in women. Reassuring data from accidental pregnancies that have occurred in the clinical trials of approved COVID-19 vaccines indicate that vaccination does not harm fertility or increase the rate of miscarriage. Scientists have quickly related to good tissue practices in vitro fertilization and a rethink is on about encouraging biopsies and focusing on safe vitrification protocols keeping in mind that ova, sperm, and embryos could be possible vectors for disease transmission with the limited research on the SARS-CoV-2 virus. Going ahead with segmented IVF without delay, freezing the generated embryos and pushing back the embryo transfer after the pandemic appears to be the best strategy at present. An international group of researchers have proposed a prognostic stratification of more vulnerable infertility cases in order to plan a progressive restart of worldwide fertility treatments.

show abstract

“…Failure to assess reproductive toxicity in the clinical trials while developing the vaccine was listed as one of the reasons for manifested vaccine hesitancy. Thus, the results of the recently published study by Gonzalez et al, which evaluated sperm parameters in 45 men before and after two doses of COVID-19 mRNA vaccines, finding no significant decreases in any sperm parameter, were well received [ 19 ].…”

mentioning

confidence: 99%