Sperm quality and oxidative stress in chub Squalius orientalis and Padanian barbel Barbus plebejus (Teleostei: Cyprinidae) after in vitro exposure to low doses of bisphenol A

Kutluyer, Filiz; Sahilli, Yeliz Çakir; Kocabaş, Mehmet; Aksu, Önder

doi:10.1080/01480545.2020.1726379

Cited by 11 publications

(1 citation statement)

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“…Some studies have reported that administration of BPA at doses of 0.2-200 mg/kg does not lead to significant alterations in reproductive parameters (Ema et al, 2001). In contrast, recent studies have shown that low doses of bisphenol A cause toxic effects to the male reproductive system (Kutluyer et al, 2020). In the present study, administration of BPA at the doses of 5 and 600 mg/kg significantly decreased the sperm count, normal sperm morphology, sperm motility and viability, which may be due to increased lipid peroxidation, disturbance of steroid biosynthesis, and inhibition of sperm production (Samova et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Effect of bromelain on sperm quality, testicular oxidative stress and expression of oestrogen receptors in bisphenol‐A treated male mice

et al. 2022

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Bisphenol A (BPA) as an endocrine-disrupting chemical (EDC) with low estrogenic activity increases oxidative stress and testicular damage. Bromelain is a mixture of different thiol endopeptidases and other components with many uses as a natural anti-inflammatory enzyme. The present study aimed to evaluate the effect of bromelain on male reproductive failure induced by BPA. A total of 60 healthy adult male mice were randomly divided into six groups (n = 6), including control, bromelain (70 mg/kg), BPA (5 and 600 mg/kg), and BPA (5 and 600 mg/kg) + bromelain. BPA and bromelain were administrated orally for 35 days. Then, the epididymis and testes were removed to evaluate sperm parameters, oxidative stress markers, serum levels of testosterone concentrations, and oestrogen receptors expression. The BPA significantly (P < 0.05) decreased sperm count, motility, viability, and normal sperm morphology, as well as testosterone levels, oestrogen receptors alpha (ERα) and beta (ERβ), GPx, CAT, and SOD activity than control. Also, BPA significantly (P < 0.05) increased the sperm anomalies, and MDA concentration. Co-administration of bromelain + BPA caused a significantly (P < 0.05) increase sperm count, normal sperm morphology, testosterone levels, expression of ERα and ERβ, and GPx, CAT, and SOD activity than the BPA group (P < 0.05). Also, Bromelain significantly (P < 0.05) decreased sperm anomalies and MDA concentration than control. Based on the results of this study, it appears that BPA causes side effects on male reproduction. While, bromelain has the potential to reduce the side effects of BPA on the male reproductive system.

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Section: Discussionmentioning

confidence: 99%