Spermatic Granuloma of the Epididymis

Lyons, Richard C.; Petre, John; Lee, Chul Nam

doi:10.1016/s0022-5347(17)63036-2

Cited by 18 publications

(7 citation statements)

References 9 publications

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“…In humans, the most commonly cited are trauma (5,7,9,15,20,22) and inflammation (7,(17)(18)(19)22). Trauma and inflammation have also been reported as causes of spermatic granulomas in animals (17,23).…”

Section: Discussionmentioning

confidence: 99%

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Intratubular Spermatic Granulomas of the Canine Efferent Ductules

1995

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Spermatic granulomas are inflammatory lesions that occur in the efferent ductule and epididymis of humans, goats, rats, and bulls. Three clinically normal dogs from a control group had histologic lesions of the initial segment of the caput epididymis consisting of intratubular spermatic granulomas. The granulomas were located within the efferent ductules, and the inflammatory response consisted primarily of aggregates of spermiophagic macrophages in the ductules. Sperm stasis of the affected ductules was evident by the dilation and accumulation of large numbers of spermatozoa in adjacent cross-sections of efferent ductules. Blind-ending efferent ductules were demonstrated by serially sectioning the initial segment of the epididymis. The intratubular granulomas did not completely occlude the outflow tract because spermatozoa were present in the cauda epididymis. While spermatic granulomas can be induced by trauma, infection, or toxins, spontaneous granulomas due to blind-ending ductules should be considered as a differential. Clinical history, location of the granuloma, and serial sectioning can help determine the most likely etiology in early cases.

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Section: Discussionmentioning

confidence: 99%

“…Spermatic granulomas have been reported in many domestic species (3,10,15,20) and in humans (5,7,9,14,(16)(17)(18)(19)21). Most reports are observational studies of end-stage lesions with severe inflammatory cell responses.…”

Section: Introductionmentioning

confidence: 99%

Intratubular Spermatic Granulomas of the Canine Efferent Ductules

1995

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“…Pathogenesis of sperm retention cysts has been attributed to direct or surgical trauma (Hubsmith et al, 1959;Mullaney, 1962;Lyons et al, 1967), lower urinary tract infection (King, 1955), chemical agents (Cooper & Jackson, 1973;Bhathal et al, 1974), congenital failure of the efferent duct to connect with the epididymal tubule (King, 1978), and autoimmune disorders after vasectomy (Schmidt, 1966). In the TE male, trauma, infection, and chemical agents can be excluded.…”

Section: Parabiosis Experimentsmentioning

confidence: 99%

“…Sperm retention cysts or spermatogranulomata in the efferent ducts are not rare in infertile men (Hubsmith et al, 1959;Taylor, 1959;Mullaney, 1962;Lyons et al, 1967), but their pathogenesis has not been clearly understood. The spontaneous occurrence of such cysts in animals would be useful.…”

Section: Introductionmentioning

confidence: 99%

Sperm retention cysts in the efferent duct and testicular atrophy of TE inbred rats

Ikadai

Fujita²,

Ajisawa³

et al. 1987

Reproduction

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Summary. Sperm retention cysts were observed in the efferent duct of TE inbred rats at 15 weeks of age. Spermatozoa agglutinated in the efferent duct with destruction of the epithelium. Testicular weight increased or decreased. Diameter of the seminiferous tubules was enlarged in testes that increased in weight and germinal cells degenerated in the atrophied testes. After 30 weeks of age, the tubules of the efferent duct were sometimes replaced by scars and testicular atrophy became more frequent. In 3 out of 5 normal rats united by parabiosis with TE males for 25\p=n-\27 days, cysts occurred in the efferent duct.

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“…Spermatic granuloma is generally believed to b= a common entity, occurring not only after vasectomy but also in association with inflammation and trauma (Cronquist, 1949;Glassy & Mostolfi;Lyons, Petre & Lee, 1967). Absorption of suture material may lead to a discharge of semen into the tissues.…”

Section: Scand J Urol Nephrol4mentioning

confidence: 99%

Regenerative Growth of the Vas Deferens Resembling a Low-Grade Carcinoma: Report of a Case

Grüner

1970

Scandinavian Journal of Urology and Nephrology

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A case is presented in which regenerative growth of the vas deferens after vasectomy presented as a small tumour at the proximal stump. The histologic picture resembled a low-grade adenocarcinoma. A concomitant inflammatory reaction of granulomatous type was probably caused by extravasated sperm.Scand J Urol Nephrol Downloaded from informahealthcare.com by University of Melbourne on 11/16/14For personal use only.

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Spermatic Granuloma of the Epididymis

Cited by 18 publications

References 9 publications

Intratubular Spermatic Granulomas of the Canine Efferent Ductules

Intratubular Spermatic Granulomas of the Canine Efferent Ductules

Sperm retention cysts in the efferent duct and testicular atrophy of TE inbred rats

Regenerative Growth of the Vas Deferens Resembling a Low-Grade Carcinoma: Report of a Case

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