Spermatogonial stem‐cell renewal in the mouse

Oakberg, E.F.

doi:10.1002/ar.1091690305

Cited by 429 publications

(270 citation statements)

References 11 publications

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“…Examples are muscle-specific stem cells, so-called satellite cells that stay in close contact to the basement membrane of myofibers and undifferentiated spermatogonia on the basement membrane of the seminiferous epithelium of the testis, where the germ stem cell niche is thought to be located. 38,39 The interaction of stem cells with extracellular matrix proteins can suppress the onset of their terminal differentiation. 40 In line with this, basal lamina proteins such as laminin and collagen type IV promote the quiescent stage of HSCs [29][30][31] and, therefore, represent important elements of their niche (Fig.…”

Section: Discussionmentioning

confidence: 99%

The niche of stellate cells within rat liver #

et al. 2009

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Section: Discussionmentioning

confidence: 99%

The niche of stellate cells within rat liver #

et al. 2009

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“…Oakberg (15) and others (14,16) have documented the highly differential radiosensitivity of these numerous cell populations in mammalian testes. The spermatogonial cells (types A 1 -A 4 , In, B) are the most sensitive to X rays (LD 50 ~ 0.40 Gy in mice), while the remaining cell populations are substantially less sensitive, with LD 50 values ranging from 2 to 600 Gy (17).…”

Section: Biological Modelmentioning

confidence: 99%

Radiotoxicity of Gadolinium-148 and Radium-223 in Mouse Testes: Relative Biological Effectiveness of Alpha-Particle Emitters In Vivo

Howell

Goddu²,

Narra³

et al. 1997

Radiation Research

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The biological effects of radionuclides that emit α particles are of considerable interest in view of their potential for therapy and their presence in the environment. The present work is a continuation of our ongoing effort to study the radiotoxicity of α-particle emitters in vivo using the survival of murine testicular sperm heads as the biological end point. Specifically, the relative biological effectiveness (RBE) of very low-energy α particles (3.2 MeV) emitted by 148 Gd is investigated and determined to be 7.4 ± 2.4 when compared to the effects of acute external 120 kVp X rays. This datum, in conjunction with our earlier results for 210 Po and 212 Pb in equilibrium with its daughters, is used to revise and extend the range of validity of our previous RBE-energy relationship for α particles emitted by tissue-incorporated radionuclides. The new empirical relationship is given by RBE α = 9.14 − 0.510 E α , where 3 < E α < 9 MeV. The validity of this empirical relationship is tested by determining the RBE of the prolific α-particle emitter 223 Ra (in equilibrium with its daughters) experimentally in the same biological model and comparing the value obtained experimentally with the predicted value. The resulting RBE values are 5.4 ± 0.9 and 5.6, respectively. This close agreement strongly supports the adequacy of the empirical RBE-E α relationship to predict the biological effects of α-particle emitters in Vivo.

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“…SSCs reside in the basal part of the seminiferous epithelium, in contact with the basement membrane. Morphologically, they are undifferentiated single cells that are not connected by intercellular bridges like the more advanced germ cells (Huckins, 1971;Oakberg, 1971;Dym and Fawcett, 1971;de Rooij and Russell, 2000). According to the model of Huckins and Oakberg (Huckins and Oakberg, 1978), SSCs renew themselves or differentiate into two daughter cells called Apaired spermatogonia (Figure 1).…”

Section: Spermatogenesis and The Spermatogonial Stem Cell Nichementioning

confidence: 99%

Gdnf signaling pathways within the mammalian spermatogonial stem cell niche

Hofmann

2008

Molecular and Cellular Endocrinology

204

178

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SummaryMammalian spermatogenesis is a complex process in which male germ-line stem cells develop to ultimately form spermatozoa. Spermatogonial stem cells, or SSCs, are found in the basal compartment of the seminiferous epithelium. They self-renew to maintain the pool of stem cells throughout life, or they differentiate to generate a large number of germ cells. A balance between SSC self-renewal and differentiation in the adult testis is therefore essential to maintain normal spermatogenesis and fertility. Maintenance and self-renewal are tightly regulated by extrinsic signals from the surrounding microenvironment, called the spermatogonial stem cell niche. By physically supporting the SSCs and providing them with growth factors, the Sertoli cell is the main component of the niche. In addition, adhesion molecules that connect the SSCs to the basement membrane and cellular components of the interstitium between the seminiferous tubules are important regulators of the niche function. This review mainly focuses on glial cell line-derived neurotrophic factor (Gdnf), which is produced by Sertoli cells to maintain SSCs self-renewal, and the downstream signaling pathways induced by this crucial growth factor. Interactions between Gdnf and other signaling pathways that maintain self-renewal, as well as the role of novel SSC-and Sertoli cell-specific transcription factors, are also discussed.

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Spermatogonial stem‐cell renewal in the mouse

Cited by 429 publications

References 11 publications

The niche of stellate cells within rat liver #

The niche of stellate cells within rat liver #

Radiotoxicity of Gadolinium-148 and Radium-223 in Mouse Testes: Relative Biological Effectiveness of Alpha-Particle Emitters In Vivo

Gdnf signaling pathways within the mammalian spermatogonial stem cell niche

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