Spermatological Examinations in Males Treated with Etretinate

Török, László

doi:10.1007/978-94-011-6349-1_17

Cited by 4 publications

(3 citation statements)

References 5 publications

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“…2,3 Studies considering the effect of synthetic retinoids on spermatogenesis have revealed contradictory results. [2][3][4][5][6][7] Moreover, acitretin, which is one of the most widely used synthetic retinoids, has been used only in one of these studies. 7 Tsamboas 3 et al .…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, another clinical study revealed an increase in the total sperm count after 12 weeks of etretinate treatment. 5 Lauharanta 7 et al . have performed the first study evaluating the relation of acitretin and spermatogenesis.…”

Section: Discussionmentioning

confidence: 99%

“…4 It has been shown that retinoids have no unfavourable effect on semen parameters in a few clinical studies. 5,6 To our knowledge, acitretin has been studied in only one of these clinical studies by using fructolytic activity of semen, an indirect method evaluating spermatogenesis, in males. 7 In that study, a significant inhibition of fructolysis, therefore of spermatogenesis has been detected at very high concentrations of acitretin.…”

Section: Introductionmentioning

confidence: 99%

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Effects of acitretin on spermatogenesis of rats

Şengör¹,

Bayramgürler²,

Müezzínoğlu³

et al. 2006

Acad Dermatol Venereol

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In this experimental study the possible effects of the acitretin on the spermatogenesis of the rats were investigated histopathologically. Thirty-nine male adult Wistar albino rats were divided into 3 groups as two experimental groups and one control group. The first group consisting 14 rats were applied orally standard dose (0.75 mg/kg/day) acitretin and the second group consisting 16 rats were applied high dose (1.5 mg/kg/day) acitretin. Acitretin was given within dimetil sulphoxide (DMSO), which was diluted with saline solution as a ratio of 1/10, in order to increase its solubility. The control group consisting 9 rats were given only saline solution including DMSO for 8 weeks. After 8 weeks of the administration, half of the rats in the first and second groups and the entire control group were sacrificed under deep ether anaesthesia and bilateral orchiectomy was made. The remaining rats were compared with the control group using a similar method at the end of 8 weeks of wash-off period. The orchiectomy materials were histopathologically evaluated under the light microscope for spermatogenesis according to parameters including spermatogenetic activity, spermatogenetic organization, seminiferous tubular diameter, interstitial Leydig cells and fibroblasts. The groups, which were evaluated at the end of the 8(th) and 16(th) weeks, were compared with the control group regarding the mentioned parameters and no statistical significance was observed among the groups. In our study it was concluded that the standard and high doses of acitretin do not have any effect on the spermatogenesis of the rats.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of acitretin on spermatogenesis of rats

Şengör¹,

Bayramgürler²,

Müezzínoğlu³

et al. 2006

Acad Dermatol Venereol

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Adverse Effects of Retinoids

1988

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Oral retinoids, synthetic derivatives of vitamin A, have been used in the treatment of various dermatoses over the last decade. The most useful drugs have been isotretinoin (13-cis-retinoic acid) for nodulocystic acne and etretinate for psoriasis vulgaris. Retinoids are also effective in the treatment of papulosquamous dermatoses other than psoriasis (i.e. inherited disorders of keratinisation), cutaneous T-cell lymphoma and in chemotherapy and chemoprevention of cancer. However, systemic administration of these compounds is frequently associated with mucocutaneous side effects, liver toxicity and abnormalities of serum lipid profiles, which might be related to an increased risk of coronary heart disease. Of particular concern is the teratogenic effect of all retinoids, which limits their use in women of child-bearing potential. Chronic toxicities from long term therapy with retinoids may result in skeletal abnormalities, usually mimicking diffuse idiopathic hyperostosis syndrome. Furthermore, the chronic use of retinoids in children may inhibit their growth due to premature epiphyseal closure. In contrast to other side effects of retinoids which are dose dependent and reversible upon withdrawal of the drug, it seems unlikely that bone abnormalities will resolve after discontinuation of the medication. In view of the wide spectrum of toxicities, treatment with retinoids requires appropriate selection of patients, careful consideration of the benefit to risk ratio for each individual, periodic monitoring of clinical response and laboratory tests. Clinicians should use special management techniques in order to prevent or minimize slide effects. Extensive investigations are currently being conducted in an attempt to develop new retinoids which will improve the therapeutic efficacy and reduce unwanted reactions.

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