Spermatological Investigations in Patients Treated with Etretinate and Isotretinoin

Török, László; Kadar, Lianna; Kasa, Marina Antunes

doi:10.1111/j.1439-0272.1987.tb01915.x

Cited by 21 publications

(5 citation statements)

References 10 publications

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“…Amory et al administered isotretinoin to patients between the ages of 21 and 60 years with impaired sperm parameters, and found no significant change in their sperm motility, but observed an increase in their sperm concentrations (12). On the other hand, some other human studies reported that isotretinoin treatment did not affect spermatogenesis and hypothalamicpituitary-gonadal axis (13)(14)(15). The reason for the different results in our study and those mentioned above may be due to the difference in molecular doses, various uncontrollable non-standard subjective factors that affect the sperm parameters of people with different physical factors such as environment and diet.…”

Section: Discussionmentioning

confidence: 99%

Does isotretinoin affect spermatogenesis in the long term? A rat model

Çırakoğlu¹,

Önder²,

Hancı³

et al. 2023

Arch Ital Urol Androl

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Objectives: Spermatogenesis, in which cell regeneration continues, can be affected by environmental, chemical, psychological factors or various diseases. There is conflicting information in the literature about the effect of isotretinoin, which is widely used in acne treatment, on testes and spermatogenesis. Therefore, we planned a rat study to evaluate the long-term efficacy of oral isotretinoin on testicular tissues and spermatogenesis. Materials and methods: The Group 1 (n = 6) 7.5 mg/kg/day and the Group 2 (n = 6) received isotretinoin at a dose of 30 mg/kg/day dissolved in sunflower oil, the Sham Group (n = 6) received only sunflower oil by gavage, and the control group (n = 6) received standard feed and water for four weeks. After the 4th week, all animals were fed with standard feed and water and followed for the next four weeks. At the end of the 8th week, all animals were sacrificed under deep anesthesia. Seminiferous tubule diameters, epithelial thickness, apoptotic index, sperm number and motility recorded. Results: Sperm count, motility, vitality, diameter of seminiferous tubule and germinal epithelium thickness were decreased and apoptotic index increased in the groups received isotretinoin. There was no significant difference between the groups in terms of testosterone levels. Conclusions: We consider that further comprehensive studies, including human clinical trials, should be conducted to examine the negative effects of isotretinoin on spermatogenesis in the long term especially when there is a need using isotretinoin in men for various reasons and to eliminate the contradictions in the literature in this regard.

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Section: Discussionmentioning

confidence: 99%

Does isotretinoin affect spermatogenesis in the long term? A rat model

Çırakoğlu¹,

Önder²,

Hancı³

et al. 2023

Arch Ital Urol Androl

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“…and Parsch et al. including a limited number of patients reported isotretinoin therapy to have no effect on spermiogram parameters [ 12 , 26 ], although these studies did not mention the presence of any testicular pathology that might affect spermiogram values in the sample. Amory et al.…”

Section: Discussionmentioning

confidence: 99%

“…As an effective treatment for moderate to severe AV, systemic isotretinoin is the first choice of treatment [ 11 ]. Studies of male fertility and the use of isotretinoin, however, are limited and include a small number of patients [ 12–17 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of systemic isotretinoin therapy on semen parameters

Gürel

Fırat

et al. 2023

Annals of Medicine

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Purpose Vitamin A has multiple functions in the human body, being involved in growth, epithelial differentiation, vision, immune function and reproduction. While normal spermatogenesis is influenced by several factors, it requires vitamin A. Systemic isotretinoin is a vitamin A derivative that is used in the treatment of many dermatological diseases, especially acne vulgaris (AV). There is limited research on the changes in semen parameters after systemic isotretinoin therapy in humans. Our study investigates the presence of varicoceles in patients undergoing systemic isotretinoin therapy for AV and examines whether there were any changes in the semen parameters before and after treatment. Methods Included in the study were 46 men patients who were scheduled for systemic isotretinoin therapy for AV. Before treatment, the patients underwent a physical examination and ultrasonography for varicoceles assessment. The patients underwent spermiogram before treatment and after 6 months of treatment. The spermiogram assessments included semen volume, sperm concentration, total sperm count, progressive motility, viability and sperm morphology. Results After treatment, there was an increase in semen volume, sperm concentration, total sperm count, progressive motility and vitality from the pre-treatment values, but a deterioration in the sperm morphology ( p < .05). Comparing patients with and without varicoceles revealed more changes in semen parameters after treatment in those with varicoceles. There was a statistically significant difference in sperm concentration ( p < .001). Conclusions Systemic isotretinoin therapy negatively affects sperm morphology, but has positive effect on other semen parameters, and these changes in semen parameters occur more frequently in patients with varicoceles. KEY MESSAGES Acne vulgaris is a very common disease and systemic isotretinoin is used as the most effective agent in its treatment. Systemic isotretinoin positively affects semen parameters except sperm morphology. Changes in semen parameters are more common in patients with varicocele.

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“…These are further demethoxylated and are eliminated through bile as glucoronide derivatives or via kidneys as soluble metabolites [9][10] . Among all three generations, tretinoin has the shortest half-life followed by bexarotene, Isotretinoin and acitretin whereas etretinate has longer half-life 11 . The pharmacokinetics of all three generation of retinoid is given in Table 2.…”

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confidence: 99%

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Spermatological Investigations in Patients Treated with Etretinate and Isotretinoin

Cited by 21 publications

References 10 publications

Does isotretinoin affect spermatogenesis in the long term? A rat model

Does isotretinoin affect spermatogenesis in the long term? A rat model

Effect of systemic isotretinoin therapy on semen parameters

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