Spermicidal Activity of the Safe Natural Antimicrobial Peptide Subtilosin

Sutyak, Katia E.; Anderson, Robert A.; Dover, Sara E.; Feathergill, Kenneth A.; Aroutcheva, Alla; Faro, Sebastian; Chikindas, Michael L.

doi:10.1155/2008/540758

Cited by 73 publications

(45 citation statements)

References 37 publications

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“…Subtilosin can inhibit the growth of several human pathogens, including the human pathogen Gardnerella vaginalis, the primary causative agent of BV (35). Most importantly, it is completely safe for human vaginal epithelial cells and healthy vaginal lactobacilli (35,36), which indicates that its inclusion in personal care products would not adversely affect human health.…”

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confidence: 99%

The Natural Antimicrobial Peptide Subtilosin Acts Synergistically with Glycerol Monolaurate, Lauric Arginate, and ε-Poly- l -Lysine against Bacterial Vaginosis-Associated Pathogens but Not Human Lactobacilli

Noll

Prichard

Khaykin

et al. 2012

Antimicrob Agents Chemother

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bSubtilosin is a cyclical antimicrobial peptide produced by Bacillus amyloliquefaciens that has antimicrobial activity against the bacterial vaginosis-associated human pathogen Gardnerella vaginalis. The ability of subtilosin to inhibit G. vaginalis alone and in combination with the natural antimicrobial agents glycerol monolaurate (Lauricidin), lauric arginate, and -poly-L-lysine was tested using a checkerboard approach. Subtilosin was found to act synergistically with all of the chosen antimicrobials. These promising results indicate that lower concentrations of subtilosin in combination with other compounds could effectively be used to inhibit growth of the pathogen, thereby decreasing the risk of developed antimicrobial resistance. This is the first report on the effects of subtilosin combined with other natural antimicrobials against G. vaginalis.

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confidence: 99%

The Natural Antimicrobial Peptide Subtilosin Acts Synergistically with Glycerol Monolaurate, Lauric Arginate, and ε-Poly- l -Lysine against Bacterial Vaginosis-Associated Pathogens but Not Human Lactobacilli

Noll

Prichard

Khaykin

et al. 2012

Antimicrob Agents Chemother

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“…Subtilosin also showed potent spermicidal activity in vitro studies with human sperm [152] and also in vivo studies in animals [153].…”

Section: Spermicidal Activity and Potential Contraceptivementioning

confidence: 93%

Bacterial Antagonist Mediated Protein Molecules

Urbizu¹,

Sparo

Bruni³

2015

Clin Exp Pharmacol

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Bacterial antagonism mediated by ribosomally synthesised peptides has gained considerable attention in recent years because of its potential applications in the control of undesirable microbiota. These peptides, generally referred to as bacteriocins, are defined as a heterogeneous group of ribosomally synthesised, proteinaceous substances (with or without further modifications) extracellularly secreted by many Gram-positive and some Gram-negative bacteria. Their mode of activity is primarily bactericidal and directed against closely related strains and species. These peptides are nearly all cationic and very often amphyphilic, which is reflected in the fact that many of these peptides kill their target cells by accumulation in the membrane causing increasing permeability and loss of barrier functions . Bacteriocins have been explored primarily as natural food preservatives, but there is much interest in exploring the application of these therapeutic peptides as antimicrobial agents since many of them exhibit antimicrobial activity against various important human pathogens.The suitability of bacteriocins such as pharmaceuticals is explored through measures of cytotoxicity, effects on the natural microbiota, and in vivo efficacy in mouse models. Bacteriocins are promising therapeutic agents.

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“…Some bacteriocins have been assayed for their ability to eliminate undesirable bacteria from the vagina, rendering promising results. For instance the circular subtilosin A, is able to kill G. vaginalis but apparently does not attack local lactobacilli, thus helping to re-establish the normal microbiota [103]. Nisin has also been tested for its capacity to inhibit pathogens in this niche, but its use is limited due to the antibacterial effect on lactobacilli.…”

Section: Bacteriocins and Probiotics In Gynecology And As Spermicidalsmentioning

confidence: 99%

Are Bacteriocins Underexploited? NOVEL Applications for OLD Antimicrobials

Montalbán-López¹,

Sánchez‐Hidalgo²,

Valdivia³

et al. 2011

CPB

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Bacteriocins are ribosomally synthesized (poly)peptides produced by almost all prokaryotic lineages. Bacteriocins from lactic acid bacteria (LAB) and bacteriocin-producer probiotic organisms have been thoroughly studied due to their wide spectra of action, the long-term use in food fermentations and the consideration of these microorganisms as beneficial for human beings. Most of the studies on the biotechnological application of diverse bacteriocins have been focused on their use as food preservatives, nisin being the prototype successfully used in alimentation. However, bacteriocins from LAB have demonstrated a remarkable potential as therapeutics for medical or veterinary uses, alone or in combination with classical antimicrobials. Their interest is even higher now that the resistance to the antibacterials used in therapeutics is growing. In this review we explore exciting opportunities for bacteriocin and probiotic applications, highlighting the possibilities for new and innovative research in order to give the necessary attention to this type of natural molecules that exhibit a great potential.

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Spermicidal Activity of the Safe Natural Antimicrobial Peptide Subtilosin

Cited by 73 publications

References 37 publications

The Natural Antimicrobial Peptide Subtilosin Acts Synergistically with Glycerol Monolaurate, Lauric Arginate, and ε-Poly- l -Lysine against Bacterial Vaginosis-Associated Pathogens but Not Human Lactobacilli

The Natural Antimicrobial Peptide Subtilosin Acts Synergistically with Glycerol Monolaurate, Lauric Arginate, and ε-Poly- l -Lysine against Bacterial Vaginosis-Associated Pathogens but Not Human Lactobacilli

Bacterial Antagonist Mediated Protein Molecules

Are Bacteriocins Underexploited? NOVEL Applications for OLD Antimicrobials

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