Spermicidal and anti-Trichomonas vaginalis activity of Brazilian Sapindus saponaria

Damke, Edílson; Tsuzuki, Joyce K.; Chassot, Francieli; Cortez, Diógenes Aparı́cio Garcia; Ferreira, Izabel Cristina Piloto; Shinobu-Mesquita, Cristiane Suemi; da-Silva, Vânia R S; Svidzinski, Terezinha Inez Estivalet; Consolaro, Márcia Edilaine Lopes

doi:10.1186/1472-6882-13-196

Cited by 24 publications

(14 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is used traditionally to cure ulcers, external wounds and inflammation. It was revealed that complimentary in vivo studies of Sapindus saponaria L. seeds should be made for establish the use as a viginal spermicidal, particularly in Brazil and Latin America [21]. Similar results were obtained in the aqueous extract of Sapindus trifoliatus L seeds.…”

Section: Resultsmentioning

confidence: 53%

“…The root of M. oleifera were shown to possess antifertility, antiinflammatory and act as a cardiac or circulatory tonic, used as an abortifacient, treating kidney pain [20]. In vitro studies on Sapindus saponaria proved that it has viginal spermicidal activity [21]. Aqueous stem bark extract of Riccinus communis L showed dose dependent loss of sperm motility by influencing the morphological deformation of spermatozoa [22].…”

Section: Indo Global Journal Of Pharmaceutical Sciences Issn 2249-102mentioning

confidence: 99%

See 1 more Smart Citation

Immobilization Effect of Traditional Contraceptive Plants on Human Sperm

Kadam¹,

Gaykar²

2018

IGJPS

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 53%

Section: Indo Global Journal Of Pharmaceutical Sciences Issn 2249-102mentioning

confidence: 99%

Immobilization Effect of Traditional Contraceptive Plants on Human Sperm

Kadam¹,

Gaykar²

2018

IGJPS

View full text Add to dashboard Cite

“…All samples induced erythrocyte lysis and release of LDH. An evaluation by Damke, Tsuzuki [28] of purified saponins of the medicinal plant of Sapindus saponaria, used traditionally to cure ulcers, external wounds, and inflammation revealed their inhibitory potency against T. vaginalis with an MIC value of 0.156 mg/ mL for nonclinical strains and 0.078 mg/mL for a clinical strain. Jain, Kumar [113] reported on a related study on the potential value of Sapindus saponaria trichomonocidal saponins for prophylactic contraception.…”

Section: Saponinsmentioning

confidence: 99%

Anti-trichomonad activities of different compounds from foods, marine products, and medicinal plants: a review

Friedman

Tam

Cheng

et al. 2020

BMC Complement Med Ther

View full text Add to dashboard Cite

Human trichomoniasis, caused by the pathogenic parasitic protozoan Trichomonas vaginalis, is the most common non-viral sexually transmitted disease that contributes to reproductive morbidity in affected women and possibly to prostate cancer in men. Tritrichomonas foetus strains cause the disease trichomoniasis in farm animals (cattle, bulls, pigs) and diarrhea in domestic animals (cats and dogs). Because some T. vaginalis strains have become resistant to the widely used drug metronidazole, there is a need to develop alternative treatments, based on safe natural products that have the potential to replace and/or enhance the activity of lower doses of metronidazole. To help meet this need, this overview collates and interprets worldwide reported studies on the efficacy of structurally different classes of food, marine, and medicinal plant extracts and some of their bioactive pure compounds against T. vaginalis and T. foetus in vitro and in infected mice and women. Active food extracts include potato peels and their glycoalkaloids α-chaconine and α-solanine, caffeic and chlorogenic acids, and quercetin; the tomato glycoalkaloid α-tomatine; theaflavin-rich black tea extracts and bioactive theaflavins; plant essential oils and their compounds (+)-α-bisabolol and eugenol; the grape skin compound resveratrol; the kidney bean lectin, marine extracts from algae, seaweeds, and fungi and compounds that are derived from fungi; medicinal extracts and about 30 isolated pure compounds. Also covered are the inactivation of drug-resistant T. vaginalis and T. foetus strains by sensitized light; anti-trichomonad effects in mice and women; beneficial effects of probiotics in women; and mechanisms that govern cell death. The summarized findings will hopefully stimulate additional research, including molecular-mechanism-guided inactivations and human clinical studies, that will help ameliorate adverse effects of pathogenic protozoa.

show abstract

“…Soapberry (Sapindus saponaria) is a native plant of Brazil [54], a medium size tree distributed all over the tropics and produce a large amount of small fruits yearly [54][55][56]. In America, Brazil and India, the fruits are traditionally used to manufacture soap [57,58] and as a clothing detergent [53,54]. Soapberry contains saponins in various parts [57].…”

Section: Documented Plant Sources Of Saponinmentioning

confidence: 99%

Detergent Plants of Northern Thailand: Potential Sources of Natural Saponins

2019

View full text Add to dashboard Cite

The natural forests of Northern Thailand are the mother source of many utilisable natural products because of their diverse flora and fauna. Northern Thai people have learned to utilise plants, in particular those of plants with cleansing properties, since the beginning of time. Several local species of detergent plants in Thailand are traditionally used by the locals and indigenous people. However, these plants may become extinct because their habitats have been replaced by industrial agriculture, and their uses have been replaced by chemically synthesised detergents. Researchers need to study and communicate the biology, phytochemistry, and the importance of these plants to conserve natural biodiversity of Northern Thailand. Of many utilisable detergent phytochemicals, natural saponins are known as bio-based surfactant and foaming agents. Their physiochemical and biological properties feature structural diversity, which leads to many industrial applications. In this review, we explained the term “detergent” from the physiological mechanism perspective and the detergent effects of saponins. We also compiled a list of Thai local plants with cleansing properties focusing on the saponin-containing plants. Future studies should investigate information relative to plant environment, ethnobotanical data, and the bioactive compound content of these plants. The knowledge acquired from this study will promote the maintenance of the local biodiversity and the conservation of the detergent plant species found in Thailand.

show abstract

Spermicidal and anti-Trichomonas vaginalis activity of Brazilian Sapindus saponaria

Cited by 24 publications

References 26 publications

Immobilization Effect of Traditional Contraceptive Plants on Human Sperm

Immobilization Effect of Traditional Contraceptive Plants on Human Sperm

Anti-trichomonad activities of different compounds from foods, marine products, and medicinal plants: a review

Detergent Plants of Northern Thailand: Potential Sources of Natural Saponins

Contact Info

Product

Resources

About