Spherical amyloid deposition in a prolactin‐producing pituitary adenoma

Gül, Şanser; Bahadir, Burak; Duşak, Abdurrahim; Kalayci, Murat; Edebali, Nurullah; Açıkgöz, Bektaş

doi:10.1111/j.1440-1789.2008.00922.x

Cited by 15 publications

(5 citation statements)

References 12 publications

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“…[5] In most reported prolactinoma cases, the male patients presented with a history of visual disturbances, headache, and erectile dysfunction, whereas the females presented with irregular menses, headache, and galactorrhea. [2] An atypical presentation, like nasal bleeding in invasive Giant prolactinomas, had been reported because of intranasal extension; likewise, in our case, the presentation was seizures. [6] It's not unusual in parasellar lesions to find a surprising diagnosis after surgery.…”

Section: Discussionsupporting

confidence: 58%

Medically responsive amyloidogenic giant sellar-parasellar prolactinoma

Singh,

Shilpi,

Kumari

et al. 2024

Surgical Neurology International

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Background: Giant prolactinomas are rare; among them, the amyloidogenic variant, prolactinomas with extensive spherical amyloid deposits, are rare, with only 30 cases reported with recommendations of surgical management contrary to the routine prolactinoma’s medical management. Case Description: We report here a case of giant amyloidogenic prolactinoma in a 32-year-old male patient who had a very atypical presentation in terms of clinical, radiological, and pathological features and responded to dopamine agonist therapy like a normal prolactinoma. Conclusion: Amyloidogenic giant prolactinomas are rare. Contrary to usual belief, even they remain medically responsive; however, more literature is required to decide their ideal management.

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Section: Discussionsupporting

confidence: 58%

Medically responsive amyloidogenic giant sellar-parasellar prolactinoma

Singh,

Shilpi,

Kumari

et al. 2024

Surgical Neurology International

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“…Toxic effect of the glucagon amyloids was twice as strong as of Aβ40 [142], confirming the data that glucagon amyloids could be pathological [143]. It is interesting that another hormone, prolactin, was found in amyloid form in patients with adenoma [144]. However, taking into account the data that amyloids of prolactin could be functional, it is not clear whether the negative effect of amyloids of prolactin is associated with pathology.…”

Section: Hormones and Amyloidsmentioning

confidence: 71%

Amyloid and Amyloid-Like Aggregates: Diversity and the Term Crisis

Matiiv

Trubitsina

Matveenko

et al. 2020

Biochemistry Moscow

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Active accumulation of the data on new amyloids continuing nowadays dissolves boundaries of the term “amyloid”. Currently, it is most often used to designate aggregates with cross-β structure. At the same time, amyloids also exhibit a number of other unusual properties, such as: detergent and protease resistance, interaction with specific dyes, and ability to induce transition of some proteins from a soluble form to an aggregated one. The same features have been also demonstrated for the aggregates lacking cross-β structure, which are commonly called “amyloid-like” and combined into one group, although they are very diverse. We have collected and systematized information on the properties of more than two hundred known amyloids and amyloid-like proteins with emphasis on conflicting examples. In particular, a number of proteins in membraneless organelles form aggregates with cross-β structure that are morphologically indistinguishable from the other amyloids, but they can be dissolved in the presence of detergents, which is not typical for amyloids. Such paradoxes signify the need to clarify the existing definition of the term amyloid. On the other hand, the demonstrated structural diversity of the amyloid-like aggregates shows the necessity of their classification.

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“…5,17 Rare cases have rounded calcium deposits or amyloid deposition (Figure 4C). 8,30,31 Densely granulated adenomas have eosinophilic to red (acidophilic) cytoplasm and…”

Section: Lactotroph Adenomamentioning

confidence: 99%

Neuropathology of Pituitary Adenomas and Sellar Lesions

2021

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The pituitary gland is the site of numerous neoplastic and inflammatory processes. The overwhelmingly most frequent tumors arise from cells of the anterior lobe, the pituitary neuroendocrine tumors (PitNETs). Immunohistochemistry assay staining for pituitary hormones is the core tool for classifying PitNETs, resulting in the diagnosis of somatotroph PitNETs, lactotroph PitNETs, and so on. For cases showing no hormonal expression, the updated WHO classification system now considers the assessment of several transcription factors: PIT-1 (pituitary-specific POU-class homeodomain transcription factor); T-PIT (T-box family member TBX19); and SF-1 (steroidogenic factor regulating gonadotroph cell differentiation) before rendering a diagnosis of null cell adenoma. Other tumors and disease processes of this site often mimic PitNETs radiographically and sometimes even clinically (ie, compression of the optic chiasm). These potpourri of processes include germ cell neoplasms (especially germinomas), tumors that originate from Rathke's pouch (craniopharyngiomas, Rathke's cleft cyst), tumors that originate from the posterior lobe of the pituitary (pituicytoma, spindle cell oncocytoma, granular cell tumor), and tumors that originate from the meninges (especially meningiomas). In addition to neoplasms, several described inflammatory and related conditions exist that need to be distinguished from PitNETs. These include lymphocytic hypophysitis and Langerhans cell histiocytosis, a neoplastic disorder of histiocytes. In this review, we aim to briefly describe the main pituitary and sellar lesions, with emphasis on the most common tumors, the PitNETs.

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Spherical amyloid deposition in a prolactin‐producing pituitary adenoma

Cited by 15 publications

References 12 publications

Medically responsive amyloidogenic giant sellar-parasellar prolactinoma

Medically responsive amyloidogenic giant sellar-parasellar prolactinoma

Amyloid and Amyloid-Like Aggregates: Diversity and the Term Crisis

Neuropathology of Pituitary Adenomas and Sellar Lesions

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