Spherical nucleic acids: emerging amplifiers for therapeutic nanoplatforms

Tao, Zhenghao; Zhang, Haitao; Wu, Shang; Zhang, Jiaheng; Cheng, Yao; Lei, Longtianyang; Qin, Yang; Wei, Hua; Yu, Cui-Yun

doi:10.1039/d3nr05971e

Nanoscale

2024

DOI: 10.1039/d3nr05971e

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Spherical nucleic acids: emerging amplifiers for therapeutic nanoplatforms

Zhenghao Tao,

Haitao Zhang,

Shang Wu

et al.

Abstract: Gene therapy is a revolutionary treatment approach in the 21st century, offers significant potential for disease prevention and treatment. However, the efficacy of gene delivery is often compromised by the...

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Cited by 5 publications

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Self‐Assembly and Biological Properties of Highly Fluorinated Oligonucleotide Amphiphiles

Laurent,

Bona,

Asohan

et al. 2024

Angewandte Chemie

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Nucleic acids, used as therapeutics to silence disease‐related genes, offer significant advantages over small molecule drugs: they provide high specificity, the ability to target "undruggable" molecules, and adaptability to a wide range of disease phenotypes. However, their instability in biological media, as well their rapid clearance from the organism limit their applicability, necessitating the use of nanocarriers to overcome these challenges. Among these strategies, spherical nucleic acids (SNA) – composed of a densely packed corona of oligonucleotides around a nanoparticle – have emerged as a powerful tool, in particular when self‐assembled from DNA amphiphiles. This non‐covalent strategy however has caveats, especially when it comes to stability in complex biological media, where these SNAs disassemble in contact to serum proteins. Here, we developed highly fluorinated DNA amphiphiles that readily self‐assemble into SNAs and have tunable stability profiles in biological media. They are made of branched fluorinated moieties with potentially improved biodegradability as compared to their linear counterparts. Depending on the number of fluorophilic interactions, the self‐assembled SNAs can have excellent serum stabilities – up to days – and readily deliver nucleic acid therapeutics for gene silencing applications. These systems show great potential as promising candidates for nucleic acid‐based therapies.

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Self‐Assembly and Biological Properties of Highly Fluorinated Oligonucleotide Amphiphiles

Laurent,

Bona,

Asohan

et al. 2024

Angewandte Chemie

View full text Add to dashboard Cite

show abstract

Self‐Assembly and Biological Properties of Highly Fluorinated Oligonucleotide Amphiphiles

Laurent,

Bona,

Asohan

et al. 2024

Angew Chem Int Ed

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A novel sensitization strategy for uncertain single stranded probe on electrode surface based on terminal deoxynucleotidyl transferase and G-rich spherical nucleic acids

Wang,

Chen,

Liu

et al. 2024

Chemical Engineering Journal

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Spherical nucleic acids: emerging amplifiers for therapeutic nanoplatforms

Abstract: Gene therapy is a revolutionary treatment approach in the 21st century, offers significant potential for disease prevention and treatment. However, the efficacy of gene delivery is often compromised by the...

Cited by 5 publications

References 137 publications

Self‐Assembly and Biological Properties of Highly Fluorinated Oligonucleotide Amphiphiles

Self‐Assembly and Biological Properties of Highly Fluorinated Oligonucleotide Amphiphiles

Self‐Assembly and Biological Properties of Highly Fluorinated Oligonucleotide Amphiphiles

A novel sensitization strategy for uncertain single stranded probe on electrode surface based on terminal deoxynucleotidyl transferase and G-rich spherical nucleic acids

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