Sphincter of Oddi injection with botulinum toxin is as effective as endobiliary stent in resolving cystic duct leaks in a canine model

Brodsky, Jason; Marks, Jeffrey M.; Malm, Jennifer A.; Bower, Andrew L.; Ponsky, Jeffrey L.

doi:10.1016/s0016-5107(02)70358-1

Cited by 20 publications

(6 citation statements)

References 12 publications

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“…In a fairly recent case, topically applied nitroglycerin (which relaxes the sphincter of Oddi) was used to heal a postcholecystectomy bile leak [34]. Botulinum toxin has also been shown in an animal model to heal bile leaks with an efficacy similar to stent insertion [35]. Currently, these strategies are experimental; thus, data from clinical trials are necessary before clinical application.…”

Section: Discussionmentioning

confidence: 99%

A comparative study of 10-Fr vs. 7-Fr straight plastic stents in the treatment of postcholecystectomy bile leak

Katsinelos¹,

Kountouras

Paroutoglou

et al. 2007

Surg Endosc

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Section: Discussionmentioning

confidence: 99%

A comparative study of 10-Fr vs. 7-Fr straight plastic stents in the treatment of postcholecystectomy bile leak

Katsinelos¹,

Kountouras

Paroutoglou

et al. 2007

Surg Endosc

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“…BT injection is as effective as endoscopic biliary stent placement in resolving cystic duct leaks in a canine model [ 139 ].…”

Section: Duodenal and Biliary Applicationsmentioning

confidence: 99%

Treatment of Gastrointestinal Sphincters Spasms with Botulinum Toxin A

Brisinda

Sivestrini

Bianco

et al. 2015

Toxins

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Botulinum toxin A inhibits neuromuscular transmission. It has become a drug with many indications. The range of clinical applications has grown to encompass several neurological and non-neurological conditions. One of the most recent achievements in the field is the observation that botulinum toxin A provides benefit in diseases of the gastrointestinal tract. Although toxin blocks cholinergic nerve endings in the autonomic nervous system, it has also been shown that it does not block non-adrenergic non-cholinergic responses mediated by nitric oxide. This has promoted further interest in using botulinum toxin A as a treatment for overactive smooth muscles and sphincters. The introduction of this therapy has made the treatment of several clinical conditions easier, in the outpatient setting, at a lower cost and without permanent complications. This review presents current data on the use of botulinum toxin A in the treatment of pathological conditions of the gastrointestinal tract.

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“…An innovation that might be applicable to bile duct leaks is the use of biodegradable stents that lose radial strength and pass spontaneously into the duodenum after 3–6 months 25 . Other novel approaches include the use of cyanoacrylate glue to occlude large fistulae 26 and the use of injections of botulinum toxin to relax the sphincter of Oddi 27 . However, the latter technique is unlikely to be superior to endoscopic sphincterotomy.…”

Section: New Frontiersmentioning

confidence: 99%