Sphincter-preserving surgery after preoperative radiochemotherapy for T3 low rectal cancers

Xue, Bai; Li, Shiyong; Yu, Bo; Hong, Seung‐Mo; Jin, Weisen; Chen, Gang; Du, Jianjun; Zuo, Fuyi

doi:10.3892/ol.2012.656

Cited by 9 publications

(10 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2 In rectal cancer, preoperative RCT may have paramount importance due to possible downsizing and downstaging of tumors close to the sphincter apparatus thereby increasing the sphincter preservation rate. 3 Despite relatively high response rates, some patients fail to respond or even progress during NAT. Delaying surgery and allowing metastatic development may be crucial for unresponsive patients.…”

Section: Introductionmentioning

confidence: 99%

Germline and somatic genetic predictors of pathological response in neoadjuvant settings of rectal and esophageal cancers: systematic review and meta-analysis

Salnikova

Kolobkov

2015

Pharmacogenomics J

View full text Add to dashboard Cite

Oncologists have pointed out an urgent need for biomarkers that can be useful for clinical application to predict the susceptibility of patients to preoperative therapy. This review collects, evaluates and combines data on the influence of reported somatic and germline genetic variations on histological tumor regression in neoadjuvant settings of rectal and esophageal cancers. Five hundred and twenty-seven articles were identified, 204 retrieved and 61 studies included. Among 24 and 14 genetic markers reported for rectal and esophageal cancers, respectively, significant associations in meta-analyses were demonstrated for the following markers. In rectal cancer, major response was more frequent in carriers of the TYMS genotype 2 R/2 R-2 R/3 R (rs34743033), MTHFR genotype 677C/C (rs1801133), wild-type TP53 and KRAS genes. In esophageal cancer, successful therapy appeared to correlate with wild-type TP53. These results may be useful for future research directions to translate reported data into practical clinical use.

show abstract

Section: Introductionmentioning

confidence: 99%

Germline and somatic genetic predictors of pathological response in neoadjuvant settings of rectal and esophageal cancers: systematic review and meta-analysis

Salnikova

Kolobkov

2015

Pharmacogenomics J

View full text Add to dashboard Cite

show abstract

“…Despite the encouraging results from Wang et al , which mirror those recently reported from Beijing using a neoadjuvant approach followed by TME for distal rectal cancers, [ 5 ] the numbers are at this stage too small to result in adequate conclusions regarding this hybrid approach, where four out of nine cases still had lymph node involvement despite a partial response. Although it would appear that objective tumor shrinkage—as measured by magnetic resonance imaging (MRI) or even by barium enema—may assist in correlating with the final histological response [ 6 ], our assessment of responders who were less likely to have involved perirectal lymph nodes is still limited, where early FDG-PET responsiveness not only correlates with pathological response but also with relapse-free survival when TME is performed after neoadjuvant therapy for locally advanced cases [ 7 ].…”

mentioning

confidence: 78%

Commentary on neoadjuvant therapy followed by local excision and two-stage total mesorectal excision: a new strategy for sphincter preservation in locally advanced ultra-low rectal cancer

Zbar

2014

Gastroenterology Report

View full text Add to dashboard Cite

“…The deep, superficial and subcutaneous components of external anal sphincter and internal anal sphincter all lie caudal to our incision site. [20,21] Data from TAMIS procedures suggest that the risk of anal sphincter injury and dysfunction is relatively low. [22,23] Some of the limitations inherent to single port surgery also apply to TRRP.…”

Section: Discussionmentioning

confidence: 99%

The transrectal single port laparoscopic radical prostatectomy in a cadaver model

Akça¹,

Zargar²,

Autorino³

et al. 2015

Turkish Journal of Urology

View full text Add to dashboard Cite

Objective: To explore the feasibility of laparoscopic trans-rectal Natural Orifice Transluminal Endoscopic Surgery (NOTES) radical prostatectomy in a cadaveric model and to define anatomical landmarks of this surgical route. Material and methods:After the ethical clearance, the study was conducted in Turkish Council of Forensic Medicine. With the cadaver in an exaggerated lithotomy position, a full thickness incision was made on the anterior wall of the rectum. The anteriorly visible Denonvilliers' fascia was incised sharply, exposing the posterior surface of the prostate. A single-port device (GelPOINT ® Path) was inserted transanally passing the incision on the anterior wall of the rectum, into the bluntly created space between rectum and prostate. Three, 10 mm ports were placed through the GelPOINT ® Path, at 3, 6, and 9 o'clock positions. A 5 mm, 0° degree lens was introduced at 6 o'clock position; followed by laparoscopic scissors and laparoscopic grasper. Prostatic and periprostatic anatomy was defined as encountered during each step of the procedure. Results:Exposure of the posterior surface of the prostate and seminal vesicles was easily achieved. No additional openings of the rectal wall were made. Surgical specimen was extracted keeping its integrity. Conclusion:Transrectal radical prostatectomy is technically feasible in the cadaver model, being facilitated by previous experience with perineal surgery. Anatomical observations during the present experimental study suggest that the transrectal NOTES route provides good exposure of the operative field and easy access to the posterior surface of prostate, Future experimental endeavors should focus on reproducibility of this approach and feasibility of lymph node dissection using trans-rectal route.

show abstract

Sphincter-preserving surgery after preoperative radiochemotherapy for T3 low rectal cancers

Cited by 9 publications

References 30 publications

Germline and somatic genetic predictors of pathological response in neoadjuvant settings of rectal and esophageal cancers: systematic review and meta-analysis

Germline and somatic genetic predictors of pathological response in neoadjuvant settings of rectal and esophageal cancers: systematic review and meta-analysis

Commentary on neoadjuvant therapy followed by local excision and two-stage total mesorectal excision: a new strategy for sphincter preservation in locally advanced ultra-low rectal cancer

The transrectal single port laparoscopic radical prostatectomy in a cadaver model

Contact Info

Product

Resources

About