Sphingolipid levels in catfish consuming Fusarium moniliforme corn culture material containing fumonisins

Goel, Sharad; Lenz, Stephen D.; Lumlertdacha, Sonkphan; Lovell, Richard T.; Shelby, Richard A.; Li, Menghe H.; Riley, Ronald T.; Kemppainen, Barbara W.

doi:10.1016/0166-445x(94)00050-6

Cited by 33 publications

(25 citation statements)

References 18 publications

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“…The SA:SO ratios increase as a consequence of the accumulation of SA in tissues and serum resulting from FB^ inhibition of Nacyltransferase, the enzyme required to convert SA to SO. Fumonisin Bi inhibition of sphingolipid biosynthesis resulted in an increase in the SA:SO ratio in liver hepatocytes (Wang et al, 1991), cultured renal cells (Yoo et al, 1992), blood serum of ponies , blood serum, liver, lung, and kidneys of pigs (Riley et al, 1993), and blood serum, kidney, liver, and muscle of catfish (Goel et al, 1994). Similar increases in serum SA: SO ratios were observed in previous studies in turkeys fed the lowest level of FCM that supplied 75 mg FBi/kg (Weibking et al, 1993a(Weibking et al, , 1994(Weibking et al, , 1995.…”

Section: Discussionmentioning

confidence: 98%

Effects of Feeding Fusarium moniliforme Culture Material, Containing Known Levels of Fumonisin B1, in the Young Turkey Poult

1996

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The effects of feeding Fusarium moniliforme culture material, containing known concentrations of fumonisin B1 (FB1), were studied in turkey poults. Day-old poults were allotted randomly to dietary treatments containing 0, 0.41, 0.82, 1.23, 1.64. 2.87, 4.10, 5.33, 6.56, and 7.79% fumonisin culture material (FCM). These levels of FCM supplied 0, 25, 50, 75, 100, 175, 250, 325, 400, and 475 mg FB1/kg of feed. Each dietary treatment was fed to six pen replicates of six poults each for 21 d. Poults fed FCM that supplied 325 to 475 mg FB1/kg diet had lower (P < 0.05) feed intakes and BW gains. Increased (P < 0.05) liver and pancreas weights were observed in poults fed FCM that supplied > or = to 175 mg FB1/kg. Poults fed FCM that supplied 400 and 475 mg FB1/kg diet had increased (P < 0.05) red blood cell counts and increased (P < 0.05) serum concentrations of gamma glutamyl transferase and aspartate aminotransferase. Compared with controls, poults fed FCM that supplied 25, and 75 to 475 mg FB1/kg had increased (P < 0.05) liver sphinganine:sphingosine ratios. Hepatocellular hyperplasia was mild at 75 and 100 mg FB1/kg diet, moderate to severe at 250 mg/kg FB1, and severe at 325 to 475 mg FB1/kg. Multifocal to generalized loss of cross striations and thinning of cardiomyocytes was observed in poults fed FCM that supplied 475 mg FB1/kg diet. Results indicated that diets containing < or = to 1.23% FCM that supplied > or = to 75 mg FB1 /kg are toxic to young turkeys.

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Section: Discussionmentioning

confidence: 98%

Effects of Feeding Fusarium moniliforme Culture Material, Containing Known Levels of Fumonisin B1, in the Young Turkey Poult

1996

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“…Percentage live spermatozoa that declined with an increase in the FB 1 level in the diets may be attributed to the toxin being probably toxic to the sperm cells in the testicles since fumonisin has been reported to be widely distributed in the tissue of the animals following ingestion (Prelusky et al 1996). In their studies, Goel et al (1994), Gumprecht et al (1995) and US NTP (1999) reported hepatotoxicity and nephrotoxicity of FB 1 , and that relative to other tissues examined, the liver and kidney showed the greatest increase in the concentration of free sphinganine, a detectable biomarker for exposure to fumonisins . Rabbits have also been reported to be very sensitive to the toxic effects of FB 1 (LaBorde et al 1997).…”

Section: Discussionmentioning

confidence: 99%

Effects of dietary fumonisin B1 on the onset of puberty, semen quality, fertility rates and testicular morphology in male rabbits

Ewuola¹,

Egbunike²

2010

Reproduction

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The influences of dietary fumonisin B 1 (FB 1 ), a metabolite of Fusarium verticillioides, on the onset of puberty, semen quality, fertility rates and testicular morphology in male rabbits (bucks) were studied. Forty male rabbits were randomly assigned and fed four diets containing 0.13, 5.0, 7.5 and 10.0 mg FB 1 /kg, constituting diets 1 (control), 2, 3 and 4 respectively, for a period of 175 days in a completely randomized design. During the last week of the feeding trial, two untreated female rabbits were mated to each of the four treated bucks per treatment to assess the fertility rate of the treated bucks. Onset of puberty in animals fed diets 3 and 4 was significantly (P!0.05) delayed by some 9-12 days. The weight at puberty, sperm concentration and total sperm/ejaculate were not significantly influenced by the dietary FB 1 . Sperm mass activities, motility and live spermatozoa of the rabbits' semen significantly (P!0.05) declined with an increase in the dietary FB 1 . The highest sperm cell abnormalities were recorded in the animals fed 10.0 mg/kg FB 1 , while the least was observed in the control animals. The conception rate, litter size and embryo survival rate were statistically the same among the dietary treatments. Embryo mortality was significantly (P!0.05) higher in rabbits fed diets 3 and 4 than in others. Testicular elements were significantly (P!0.05) impaired by the toxin in rabbits fed 7.5 and 10.0 mg FB 1 /kg. This suggests that LOAEL of 7.50 mg/kg FB 1 delayed puberty, impaired semen quality and spermatogenesis and induced embryo mortality without a statistically adverse effect on the fertility rates of male rabbits.

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“…In aquaculture species, fumonisin B1 has been associated with reduced growth rate, feed consumption and feed efficiency ratio and impaired sphingolipid metabolism (Goel et al . ; Li et al . ; Lumlertdacha et al .…”

Section: Mycotoxins In Aquafeedmentioning

confidence: 99%

Occurrence of mycotoxins in commercial aquafeeds in Asia and Europe: a real risk to aquaculture?

Gonçalves¹,

Naehrer²,

Santos³

2016

Reviews in Aquaculture

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There is increasing awareness of the negative effects of mycotoxins in aquatic species, which is highlighted in recent publications. Partly due to climate change associated with an overall increase of mycotoxins contamination in plant ingredients, and also due to the tendency to replace expensive animal‐derived proteins, such as fish meal, by more economical plant proteins sources, which increases the probability of mycotoxin contamination in aquaculture feeds (Hooft et al. ). Over a 1‐year period, 41 samples of finished aquaculture feed, both shrimp and fish, were analysed within the scope of BIOMIN mycotoxin survey programme. The samples were tested for aflatoxins, zearalenone, deoxynivalenol, fumonisins and ochratoxin A. Samples were sourced in Asia (31 samples) and Europe (10 samples) from fish/shrimp farms or feed producers. The values detected pose a risk for several important aquaculture species, assuming single mycotoxin contamination, that is excluding possible additive and synergetic effects between mycotoxins. Co‐occurrence of mycotoxins in feeds may induce synergistic effects and increase the negative impact of mycotoxins in aquatic‐farmed species at lower levels than when present in single contamination. This review gives an overview of the different mycotoxins and revises the effects of mycotoxins in aquatic species. Additionally, it reports the levels of mycotoxins in aquafeeds in 2014 and compares detected levels with possible negative effects in fish and shrimp. As it is highlighted by the results of the survey, the risk of co‐occurrence is high and the knowledge on the effects of multimycotoxins contamination in aquatic species is basically none.

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Sphingolipid levels in catfish consuming Fusarium moniliforme corn culture material containing fumonisins

Cited by 33 publications

References 18 publications

Effects of Feeding Fusarium moniliforme Culture Material, Containing Known Levels of Fumonisin B1, in the Young Turkey Poult

Effects of Feeding Fusarium moniliforme Culture Material, Containing Known Levels of Fumonisin B1, in the Young Turkey Poult

Effects of dietary fumonisin B1 on the onset of puberty, semen quality, fertility rates and testicular morphology in male rabbits

Occurrence of mycotoxins in commercial aquafeeds in Asia and Europe: a real risk to aquaculture?

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