Sphingolipid Metabolism: Roles in Signal Transduction and Disruption by Fumonisins

Merrill, Alfred H.; Sullards, M. Cameron; Wang, Elaine; Voss, Kenneth A.; Riley, Ronald T.

doi:10.2307/3435020

Cited by 149 publications

(157 citation statements)

References 41 publications

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“…Instead, we found that A. machipongonensis crude lipid extracts enriched in sphingolipids robustly induced rosette development (Figure 3A). In animals, sphingolipid signaling pathways regulate developmental processes such as cell death, survival, differentiation, and migration (Prieschl and Baumruker 2000; Pyne and Pyne 2000; Spiegel and Milstien 2000; Hannun et al 2001; Merrill et al 2001; Herr et al 2003). Moreover, sphingolipids serve essential functions both as structural components of cell membranes and as signaling molecules in diverse eukaryotes (Hannich et al 2011).…”

Section: Resultsmentioning

confidence: 99%

A bacterial sulfonolipid triggers multicellular development in the closest living relatives of animals

Alegado

Brown

Cao

et al. 2012

eLife

230

242

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Bacterially-produced small molecules exert profound influences on animal health, morphogenesis, and evolution through poorly understood mechanisms. In one of the closest living relatives of animals, the choanoflagellate Salpingoeca rosetta, we find that rosette colony development is induced by the prey bacterium Algoriphagus machipongonensis and its close relatives in the Bacteroidetes phylum. Here we show that a rosette inducing factor (RIF-1) produced by A. machipongonensis belongs to the small class of sulfonolipids, obscure relatives of the better known sphingolipids that play important roles in signal transmission in plants, animals, and fungi. RIF-1 has extraordinary potency (femtomolar, or 10−15 M) and S. rosetta can respond to it over a broad dynamic range—nine orders of magnitude. This study provides a prototypical example of bacterial sulfonolipids triggering eukaryotic morphogenesis and suggests molecular mechanisms through which bacteria may have contributed to the evolution of animals.DOI: http://dx.doi.org/10.7554/eLife.00013.001

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Section: Resultsmentioning

confidence: 99%

A bacterial sulfonolipid triggers multicellular development in the closest living relatives of animals

Alegado

Brown

Cao

et al. 2012

eLife

230

242

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“…In cultured cells, prolonged exposure to FB 1 has been demonstrated to reduce intestinal barrier integrity (137) , and to cause an increase in the ease of movement of macromolecules across the monolayer (138) . The mechanism(s) for such an effect remains unknown, though it is clearly established that fumonisins disrupt sphingolipid metabolism, key components in the integrity of the cell membranes (67,78) . A recent survey from Tanzania suggests an association between estimated FB consumption at age 6 months and the subsequent height and weight of the child at the age of 12 months (139) .…”

Section: Fumonisin B Deoxynivalenol and Growth Falteringmentioning

confidence: 99%

The role of biomarkers in evaluating human health concerns from fungal contaminants in food

et al. 2012

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Mycotoxins are toxic secondary metabolites that globally contaminate an estimated 25 % of cereal crops and thus exposure is frequent in many populations. Aflatoxins, fumonisins and deoxynivalenol are amongst those mycotoxins of particular concern from a human health perspective. A number of risks to health are suggested including cancer, growth faltering, immune suppression and neural tube defects; though only the demonstrated role for aflatoxin in the aetiology of liver cancer is widely recognised. The heterogeneous distribution of mycotoxins in food restricts the usefulness of food sampling and intake estimates; instead biomarkers provide better tools for informing epidemiological investigations. Validated exposure biomarkers for aflatoxin (urinary aflatoxin M 1 , aflatoxin -N7-guaunine, serum aflatoxin -albumin) were established almost 20 years ago and were critical in confirming aflatoxins as potent liver carcinogens. Validation has included demonstration of assay robustness, intake v. biomarker level, and stability of stored samples. More recently, aflatoxin exposure biomarkers are revealing concerns of growth faltering and immune suppression; importantly, they are being used to assess the effectiveness of intervention strategies. For fumonisins and deoxynivalenol these steps of development and validation have significantly advanced in recent years. Such biomarkers should better inform epidemiological studies and thus improve our understanding of their potential risk to human health.

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“…It was also reported that gestational exposure to fumonisins may result in birth defects, such as neural tube defects (Hendricks, 1999). Several modes of action have been postulated to explain fumonisin-induced toxicity, but the primary hypothesis involves disruption of de novo sphingolipid biosynthesis (Merrill, Sullards, Voss, & Riley, 2001). Fumonisins are specifi c inhibitors of sphinganine N-acyltransferase (ceramide synthase), a key enzyme in the biosynthesis of sphingolipids.…”

Section: Introductionmentioning

confidence: 99%

Fumonisin level in corn-based food and feed from Linxian County, a high-risk area for esophageal cancer in china

et al. 2008

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Sphingolipid Metabolism: Roles in Signal Transduction and Disruption by Fumonisins

Cited by 149 publications

References 41 publications

A bacterial sulfonolipid triggers multicellular development in the closest living relatives of animals

A bacterial sulfonolipid triggers multicellular development in the closest living relatives of animals

The role of biomarkers in evaluating human health concerns from fungal contaminants in food

Fumonisin level in corn-based food and feed from Linxian County, a high-risk area for esophageal cancer in china

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