Sphingolipids

Futerman, Anthony H.

doi:10.1016/b978-0-12-824048-9.00009-2

Cited by 10 publications

(10 citation statements)

References 82 publications

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“…SLs are integral components of cellular membranes that are well conserved across eukaryotic organisms but also are found in a diverse range of species, including bacteria [ 44 , 45 ]. Recent discoveries have shown that SLs are essential components of membrane-rafts and numerous signalling pathways [ 45 , 46 ].…”

Section: Discussionmentioning

confidence: 99%

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Profiling lipidomic changes in dengue-resistant and dengue-susceptible strains of Colombian Aedes aegypti after dengue virus challenge

Elliott,

Caicedo,

Haunerland

et al. 2023

PLoS Negl Trop Dis

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The mosquito Aedes aegypti is the primary vector for all four serotypes of dengue viruses (DENV1-4), which infect millions across the globe each year. Traditional insecticide programs have been transiently effective at minimizing cases; however, insecticide resistance and habitat expansion have caused cases of DENV to surge over the last decade. There is an urgent need to develop novel vector control measures, but these are contingent on a detailed understanding of host-parasite interactions. Here, we have utilized lipidomics to survey the profiles of naturally DENV-resistant (Cali-MIB) or susceptible (Cali-S) populations of Ae. aegypti, isolated from Cali, Colombia, when fed on blood meals containing DENV. Control insects were fed on a DENV-free blood meal. Midguts were dissected from Cali-MIB and Cali-S females at three time points post-infectious blood meal, 18, 24 and 36h, to identify changes in the lipidome at key times associated with the entry, replication and exit of DENV from midgut cells. We used principal component analysis to visualize broad patterns in lipidomic profiles between the treatment groups, and significance analysis of microarray to determine lipids that were altered in response to viral challenge. These data can be used to identify molecules or metabolic pathways particular to the susceptible or refractory phenotypes, and possibly lead to the generation of stable, DENV-resistant strains of Ae. aegypti.

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Section: Discussionmentioning

confidence: 99%

“…SLs are amphipathic molecules made of a sphinganine or sphingosine backbone with a fatty acid molecule attached; they comprise up to 30% of cellular membranes [ 45 ]. Ceramide makes up the basic building block of SLs and is formed through linking a long-chain fatty acid to sphingosine via an amide bond [ 24 , 45 ].…”

Section: Discussionmentioning

confidence: 99%

Profiling lipidomic changes in dengue-resistant and dengue-susceptible strains of Colombian Aedes aegypti after dengue virus challenge

Elliott,

Caicedo,

Haunerland

et al. 2023

PLoS Negl Trop Dis

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“…Ceramides are composed of sphingosine linked to a fatty acid varying in length from C14 to C32. Sphingomyelin (SM) consists of a sphingosine base with an 18‐carbon chain and a double bond at position 4, attached to a phosphorylcholine fatty acid (Futerman, 2016). Glycosphingolipids (GSL) consist of a carbohydrate attached to the 1‐hydroxyl of ceramides through a glycosidic bond in the β configuration, these are subdivided into different groups, cerebrosides (which has a single glucose or galactose at the 1‐hydroxy position); gangliosides (which are sialic acid‐containing glycosphingolipids) (Futerman & Platt, 2017) and globosides (which contain two or more sugar residues and an N‐acetylgalactosamine group linked to ceramide) (Bhagavan & Ha, 2015).…”

Section: Sphingolipids In Cell Functionmentioning

confidence: 99%

“…Moreover, several SLs bind to proteins and regulate their activity, acting as first or second messengers of several transduction pathways. For example, Sphingosine‐1‐phosphate (S1P) regulates cell migration, embryonic development of the heart, and lymphocyte trafficking as a first messenger (Futerman, 2016). Ceramide acts as a second messenger and regulate the activity of a wide range of proteins, such as protein kinase Cζ, phospholipase A2, cathepsin D, Jun‐N‐terminal kinases, c‐Raf‐1, G‐proteins like Ras and Rac and Src‐like tyrosine kinases (Venkataraman & Futerman, 2000).…”

Section: Sphingolipids In Cell Functionmentioning

confidence: 99%

“…SLs are also coupled to cell adhesion sites for protein signaling pathways. Accordingly, SLs self‐associate into the membrane lipid bilayer leading to the fusion of GSL and cholesterol lipid rafts into large signaling macrodomains that trap and cluster signaling proteins, triggering signal initiation and amplification through protein oligomerization (Futerman, 2016). Through this mechanism, SLs modulate a wide range of cell processes, such as cell death, proliferation, differentiation, senescence, and inflammation (Colombaioni & Garcia‐Gil, 2004; Hirabayashi et al, 2006).…”

Section: Sphingolipids In Cell Functionmentioning

confidence: 99%

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Contribution of ceramides metabolism in psychiatric disorders

Bernal-Vega

García-Juárez

Camacho‐Morales

2023

Journal of Neurochemistry

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Psychiatric disorders affect 970 million people worldwide, representing a significant source of disability. Although the underlying neurobiological traits for these disorders are not fully understood, a complex interplay between psychological, environmental, and biological factors contributes to their outcomes. Recent advances in lipidomic analysis and artificial intelligence algorithms have improved the identification of selective lipid species modulating the susceptibility to mental disorders. Sphingolipids (SLs) and ceramides‐related SLs are among the most abundant lipids species in the brain that support major key pathways during neurodevelopment and brain plasticity. High levels of ceramides in plasma and brain contribute to psychiatric illness susceptibility in humans and animal models. However, the neuropathological mechanism regarding the involvement of ceramides in these disorders remain inconclusive. The brain is highly susceptible to nutritional insults, which could lead to functional impairment and influence the development and progression of psychiatric disorders. While the brain relies on glucose metabolism to support its physiological needs, a selective nutrient formula appears to have greater effects on brain health than others. For instance, consumption of high‐energy diets is associated with brain anatomical, physiological, and metabolic changes, including ceramides metabolism. Herein, we will address the contribution of ceramides metabolism as a modulator of major psychiatric disorders such as depression, anxiety, bipolar disorder, schizophrenia, and attention deficit‐hyperactivity disorder. We will also describe molecular and cellular targets of ceramides metabolism assisting the maintenance and progression of psychiatric disorders and their modulation by dietary formulas as non‐pharmacologic treatments.

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A Sphingolipid Fatty Acid Constituent Made by Alkyne trans‐Hydrogenation: Total Synthesis of Symbioramide

Radkowski

Fürstner

2022

Adv Synth Catal

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A scalable approach to (2R)‐hydroxyoctadec‐3‐enoic acid ((−)‐2) is reported, which is the fatty acid constituent of numerous sphingolipids of biological significance. Key to success was the chemoselective trans‐hydrogenation of a functionalized propargylic alcohol precursor with [Cp*RuCl]4 as the catalyst, followed by lipase‐catalyzed resolution of the racemic product. (−)‐2 then served the shortest total synthesis of the marine natural product symbioramide known to date.

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Sphingolipids

Cited by 10 publications

References 82 publications

Profiling lipidomic changes in dengue-resistant and dengue-susceptible strains of Colombian Aedes aegypti after dengue virus challenge

Profiling lipidomic changes in dengue-resistant and dengue-susceptible strains of Colombian Aedes aegypti after dengue virus challenge

Contribution of ceramides metabolism in psychiatric disorders

A Sphingolipid Fatty Acid Constituent Made by Alkyne trans‐Hydrogenation: Total Synthesis of Symbioramide

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