Sphingolipids and the sphingosine kinase inhibitor, SKI II, induce BCL‐2‐independent apoptosis in human prostatic adenocarcinoma cells

Abstract

Thus, in contrast to the inhibitory effects of BCL-2 on apoptosis induced by various agents in tumor cells, SKI II and selected pro-apoptotic SLs appear atypical in their independence from such inhibition, and may have merits as new candidates for treatment of AI PC.

Expressions of Sphingosine-1-phosphate (S1P) Receptors, Sphingosine Kinases in Malignant Bone and Soft Tissue Tumors, and The role of Sphingosine Kinase-1 in Growth of MFH Cell Lines

“…SPHK1 is frequently overexpressed in a varietly of solid tumors, suggesting a potential oncogenic function and an important role in human tumorigenesis. Recently SPHK1 inhibitors have shown to decrease proliferation of cancer cell lines [32][33][34][35][36]. In the current study, we could confirm that all MFH cell lines expressed SPHK1 proteins by Western blotting.…”

“Inside-Out” Signaling of Sphingosine-1-Phosphate: Therapeutic Targets

“…More recently, 2-(phydroxyanilino)-4-(p-chlorophenyl)thiazole was shown to kill both androgen-sensitive (LNCaP) and hormoneresistant human prostate cancer cells (PC-3), regardless of their p53 status, notably by tilting the ceramide/S1P biostat toward ceramide (Pchejetski et al, 2005). These compounds are now commercially available (Calbiochem or ChemBridge Corp, San Diego, CA), and they have been used in several other studies, including studies in murine bone marrow-derived dendritic cells (Jung et al, 2007a,b), murine cardiac cells (Pchejetski et al, 2007), human prostatic adenocarcinoma cells (Leroux et al, 2007), and a rat hemorrhagic shock model (Lee et al, 2004).…”

Bioactive sphingolipids in docetaxel-induced apoptosis in human prostate cancer cells

“…Inhibition of SK-1 activity was shown to increase cancer cells sensitivity to anticancer agents [15,16]. Up-regulation of SK-1 and S1P levels were determined in various types of cancer cells [17,18].…”