2016
DOI: 10.4155/fmc-2016-0053
|View full text |Cite
|
Sign up to set email alerts
|

Sphingolipids as Targets for Treatment of Fungal Infections

Abstract: Invasive fungal infections have significantly increased in the last few decades. Three classes of drugs are commonly used to treat these infections: polyenes, azoles and echinocandins. Unfortunately each of these drugs has drawbacks; polyenes are toxic, resistance against azoles is emerging and echinocandins have narrow spectrum of activity. Thus, the development of new antifungals is urgently needed. In this context, fungal sphingolipids have emerged as a potential target for new antifungals, because their bi… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

3
73
0
1

Year Published

2017
2017
2024
2024

Publication Types

Select...
4
3

Relationship

1
6

Authors

Journals

citations
Cited by 77 publications
(77 citation statements)
references
References 119 publications
3
73
0
1
Order By: Relevance
“…necessary for virulence and defensin recognition. 9,10 This same lipid target was described to be root for other PDs, as Psd1 and RsAFP2. 11,12 Antimicrobial peptides are regarded as potential targets for the development of novel therapeutics drugs mainly due to antimicrobial resistance.…”
mentioning
confidence: 83%
See 1 more Smart Citation
“…necessary for virulence and defensin recognition. 9,10 This same lipid target was described to be root for other PDs, as Psd1 and RsAFP2. 11,12 Antimicrobial peptides are regarded as potential targets for the development of novel therapeutics drugs mainly due to antimicrobial resistance.…”
mentioning
confidence: 83%
“…The antifungal mechanism of Ps d2 is not fully understood, but α‐OH‐Δ4,Δ8‐9,methyl‐glucosylceramide, a glycosphingolipid present in fungal membranes, plays a key role for the peptide‐interaction . Sphingolipids also play an essential role in controlling fungal virulence and a particular structure is necessary for virulence and defensin recognition . This same lipid target was described to be root for other PDs, as Ps d1 and Rs AFP2 …”
Section: Introductionmentioning
confidence: 99%
“…Sphingolipids are important in cellular metabolism but can also be important in the regulation of the fungal virulence composite. There are now diverse strategies that could be used to block the synthesis and/or function of sphingolipids 43 . Several new compounds ( N ′-(3-bromo-4-hydroxybenzylidene)-2-methyl benzohydrazide and its derivative, 3-bromo- N ′-(3-bromo-4-hydroxybenzylidene) benzohydrazide) have been found to selectively decrease levels of fungal glycosphingolipids relative to the mammalian ones.…”
Section: Novel Pathways and Targetsmentioning
confidence: 99%
“…4) The small sphingolipid molecules, sphingosine (Sph), dihydrosphingosine (dhSph), sphingosine-1-phosphate (Sph1P), and dhSph-1-phosphate (dhSph1P), have an important role in modulation of host immune response toward Cryptococcus infection (26,27). Altogether, these published reports by our group and others have emphasized the significance of the sphingolipid biosynthetic pathway for the development inhibitors as treatment strategies against Cryptococcus (28,29).…”
mentioning
confidence: 99%
“…Lipid biosynthetic pathways have been a major resource in the development treatment measures for cryptococcal infections (28). The antifungals, amphotericin B (a polyene) and fluconazole (an azole), are commonly used for targeting fungal ergosterol biosynthesis (30).…”
mentioning
confidence: 99%