Sphingomonas paucimobilis Septic Shock in an Immunocompetent Patient

Alkhatib, Bailey; Veytsman, Eric; Klumpp, Linda C; Hayes, Edwin

doi:10.7759/cureus.26720

Cited by 6 publications

(4 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Collectively, these data indicate the possibility of the existence of different AMR bacteria within the ticks that needs further research impetus. Furthermore, almost all isolated bacterial species can infect and spread between animals and humans, causing economic and health-related problems (25)(26)(27)(28)(29)(30)(31). To our knowledge, this is the first report in the region about ticks and their association with AMR bacteria.…”

Section: Discussionmentioning

confidence: 93%

Isolation, identification and antimicrobial susceptibility of the bacteria isolated from Hyalomma dromedarii infesting camels in Al-Jouf province, Saudi Arabia

Aljasham,

Damra,

Alkahtani

et al. 2023

Front. Vet. Sci.

View full text Add to dashboard Cite

Ticks are important ectoparasites that transmit various pathogens causing morbidity and mortality in humans and animals. Saudi Arabia faces several challenges that can contribute to the emergence and spread of antimicrobial resistance (AMR) bacteria. These challenges require collaborative efforts to successfully achieve significant control of AMR in the country. The present study aims to isolate bacteria from camels' tick Hyalomma dromedarii in Al-Jouf province to identify and determine these isolates' antimicrobial susceptibilities. Forty-nine ticks were collected from dromedary camels and morphologically classified as H. dromedarii. Ticks were then homogenized and plated individually, which resulted in the isolation of 55 bacteria. The results showed that the bacterial isolates belong to 20 different species. About 71% (n = 39) of the total isolates were identified as Gram-positive bacteria comprised of 11 different species, while 29% (n = 16) of the total isolates were Gram-negative bacteria comprised of 9 different species. The most prevalent isolate within the total samples was Staphylococcus lentus (22.45%, 11/49), followed by Staphylococcus pseudintermedius (18.37%, 9/49) and Sphingomonas paucimobilis (16.33% 8/49). The antimicrobial susceptibility profile of Gram-positive bacteria showed that 100% (n = 31) were resistant to benzylpenicillin; 90.3% (n = 28) were resistant to oxacillin; 58.1% (n = 18) were resistant to clindamycin; 48.4% (n = 15) were resistant to vancomycin. In addition, 32.3% (n = 10) were resistant to trimethoprim/sulfamethoxazole and rifampicin; 25.8% (n = 8) were resistant to erythromycin; 16.1% (n = 5) were resistant to teicoplanin; 6.5% (n = 2) were resistant to tetracycline. All Gram-positive bacteria were 100% susceptible to linezolid, gentamicin, tobramycin, levofloxacin, moxifloxacin, tigecycline, and nitrofurantoin. In antimicrobial susceptibility tests for the Gram-negative bacteria, 57.14% (n = 8) of the identified bacteria were resistant to ampicillin, whereas 50% (n = 7) were resistant to cefoxitin and ceftazidime. About 28.57% (n = 4) of the Gram-negative bacteria were resistant to ceftriaxone, trimethoprim/sulfamethoxazole. In addition, 21.43% (n = 3) were resistant to amoxicillin/clavulanic acid and cephalothin; 14.29% (n = 2) were resistant to cefepime and nitrofurantoin; 7.14% (n = 1) were resistant to piperacillin/tazobactam and tigecycline. However, all Gram-negative bacteria were susceptible to other examined antimicrobials. This is the first study that investigates the role of the hard tick as a potential reservoir for AMR pathogens within our region.

show abstract

Section: Discussionmentioning

confidence: 93%

Isolation, identification and antimicrobial susceptibility of the bacteria isolated from Hyalomma dromedarii infesting camels in Al-Jouf province, Saudi Arabia

Aljasham,

Damra,

Alkahtani

et al. 2023

Front. Vet. Sci.

View full text Add to dashboard Cite

show abstract

“…All of these genera of bacteria have previously been found to be present in the human nasal microbiota, although their prevalence and abundance may vary between individuals [ 71 , 72 ]. Some species of Sphingomonas are considered possible causes of nosocomial infections [ 73 ]. Burkholderiaceae is a family that includes several genera, including Burkholderia , Paraburkholderia , and Caballeronia .…”

Section: Discussionmentioning

confidence: 99%

Microbiota Profile of the Nasal Cavity According to Lifestyles in Healthy Adults in Santiago, Chile

et al. 2023

View full text Add to dashboard Cite

Background: The respiratory microbiome is dynamic, varying between anatomical niches, and it is affected by various host and environmental factors, one of which is lifestyle. Few studies have characterized the upper respiratory tract microbiome profile according to lifestyle. We explored the association between lifestyles and microbiota profiles in the upper respiratory tract of healthy adults. Methods: We analyzed nasal samples from 110 healthy adults who were living in Santiago, Chile, using 16S ribosomal RNA gene-sequencing methods. Volunteers completed a structured questionnaire about lifestyle. Results: The composition and abundance of taxonomic groups varied across lifestyle attributes. Additionally, multivariate models suggested that alpha diversity varied in the function of physical activity, nutritional status, smoking, and the interaction between nutritional status and smoking, although the significant impact of those variables varied between women and men. Although physical activity and nutritional status were significantly associated with all indexes of alpha diversity among women, the diversity of microbiota among men was associated with smoking and the interaction between nutritional status and smoking. Conclusions: The alpha diversity of nasal microbiota is associated with lifestyle attributes, but these associations depend on sex and nutritional status. Our results suggest that future studies of the airway microbiome may provide a better resolution if data are stratified for differences in sex and nutritional status.

show abstract

“…6 Trimethoprim-sulfamethoxazole, chloramphenicol, ciprofloxacin, and aminoglycosides have all been successfully used to treat this bacterium. 8 Imipenem or meropenem alone and an aminoglycoside plus a third-generation cephalosporin have been suggested as suitable antibiotics for the treatment. 9 Therapy needs to be individualized by in vitro susceptibility of the organism.…”

Section: Discussionmentioning

confidence: 99%

A Rare Presentation of Sphingomonas paucimobilis in a Healthy Child: Acute Ischemic Stroke

Yılmaz

Akcan

Pekcan

et al. 2023

J Pediatr Infect Dis

View full text Add to dashboard Cite

Sphingomonas paucimobilis is a rarely pathogenic organism that usually infects immunocompromised patients and causes nosocomial infections, but a few community-acquired infections have been identified in relatively healthy adult patients. Herein we report a 5-year-old child who presented with acute ischemic stroke caused by S. paucimobilis that was treated successfully with antibiotics and antithrombotic agents. According to our knowledge, this is the first case of acute ischemic infarction with S. paucimobilis in a previously healthy child.

show abstract

Sphingomonas paucimobilis Septic Shock in an Immunocompetent Patient

Cited by 6 publications

References 12 publications

Isolation, identification and antimicrobial susceptibility of the bacteria isolated from Hyalomma dromedarii infesting camels in Al-Jouf province, Saudi Arabia

Isolation, identification and antimicrobial susceptibility of the bacteria isolated from Hyalomma dromedarii infesting camels in Al-Jouf province, Saudi Arabia

Microbiota Profile of the Nasal Cavity According to Lifestyles in Healthy Adults in Santiago, Chile

A Rare Presentation of Sphingomonas paucimobilis in a Healthy Child: Acute Ischemic Stroke

Contact Info

Product

Resources

About