Sphingosine 1‐phosphate promotes cell migration through the activation of Cdc42 in Edg‐6/S1P4‐expressing cells

Kohno, Takayuki; Matsuyuki, Hirofumi; Inagaki, Yuichi; Igarashi, Yasuyuki

doi:10.1046/j.1365-2443.2003.00667.x

Cited by 42 publications

(39 citation statements)

References 35 publications

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“…Cer is converted to sphingosine through the action of ceramidase, and in turn the sphingosine is metabolized to sphingosine 1-phosphate (S1P) by sphingosine kinase. S1P has been found to regulate cell growth (7) and motility (8,9). Interestingly, S1P inhibits apoptosis induced by Cer and Fas ligand (10), indicating that the balance of Cer/sphingosine/S1P can affect cell phenotype.…”

mentioning

confidence: 99%

Calmodulin Is Involved in the Ca2+-dependent Activation of Ceramide Kinase as a Calcium Sensor

Mitsutake

Igarashi

2005

Journal of Biological Chemistry

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confidence: 99%

Calmodulin Is Involved in the Ca2+-dependent Activation of Ceramide Kinase as a Calcium Sensor

Mitsutake

Igarashi

2005

Journal of Biological Chemistry

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“…S1P 4 is known to couple with G i , G 12 and G 13 where binding to G i activate Cdc42, PLC and ERK and binding to G 12/13 results in Rho activation and inhibition of proliferation [47][48][49][50]. Although the understanding of the mechanisms is limited, S1P 5 has been demonstrated to couple G i and G 12 [51].…”

Section: Role In Cancer: Sphingolipid Metabolism and Signalingmentioning

confidence: 99%

Involvement of Sphingosine Kinases/Sphingosine-1-Phosphate (S1P)/S1P Receptors in Breast Cancer Subtypes

2013

J Oncobiomark

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There is emerging evidence suggesting sphingolipids as critical regulators of cancer development and progression. Sphingolipids are potent bioactive lipids involved in fundamental biological processes including cell proliferation, apoptosis, angiogenesis, senescence, stress response and transformation. Ceramide, sphingosine and Sphingosine-1-phosphate (S1P) are inter-convertible sphingolipids with opposing effects on cell fate. Furthermore, S1P either acts directly on intracellular targets or through G-protein coupled S1PRs (S1P1-5) to mediate their specific effects. This review will discuss the roles of key sphingolipids, sphingosine kinases (SphKs) and S1P receptors (S1PRs) in tumor growth and acquisition of resistance to chemotherapy in four subtypes of breast cancer that are categorized based on the status of hormone receptors and human epidermal growth factor 2 (HER2) receptors.

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“…7 S1P4 promotes cell migration, 7,8 influences cell morphology and may contribute to the fine balance of migration-stimulating. [6][7][8][9] Also S1P4 mediates immunosuppressive effects of S1P by inhibiting proliferation and secretion of effector cytokines, while enhancing secretion of the suppressive cytokine IL-10.…”

Section: Introductionmentioning

confidence: 99%

“…[6][7][8][9] Also S1P4 mediates immunosuppressive effects of S1P by inhibiting proliferation and secretion of effector cytokines, while enhancing secretion of the suppressive cytokine IL-10. 10 To date, no study has been reported on a functional cellular response regulated by S1P4 in neuroblastoma patients.…”

Section: Introductionmentioning

confidence: 99%

Behavior of Sphingosine 1-Phosphate Receptor 4 Gene Expression in Patients with Neuroblastoma

Yılmaz¹

2013

UHOD

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Sphingosine 1-phosphate receptor 4 (S1P4), which induces cellular migration and prevents apoptosis, was investigated in patients diagnosed with neuroblastoma in our study. The study included 37 neuroblastoma patients and 25 healthy children. After RNA isolation, cDNA were performed and S1P4 gene expression levels were measured in leukocytes. S1P4 gene expression levels presented as mean ± SD were high in the study group. The difference was statistically significant between neuroblastoma patients (0.0387±0.0647) and healthy children (0.0366±0.0238) for S1P4 gene expression levels (p=0.028). Patients given no chemotherapy yet and and those who already completed chemotherapy showed no significant difference statistically (p=0.886). While decreased S1P4 gene expression levels (0.0188±0.0069) were seen in patients receiving maintenance therapy, patients completed chemotherapy had increased S1P4 gene expression levels (0.0322±0.0303). The difference was meaningful (p=0.048). Although S1P4 gene expression levels (0.0310±0.0201) estimated before the beginning of chemotherapy were higher than that of maintenance phase (0.0188±0.0069), the difference was not significant (p=0.158). Higher S1P4 gene expression levels were remarkable in neuroblastoma patients. The suppression of S1P4 gene expression levels during maintenance phase and the increasing of expression in following up without chemotherapy could bring to mind that the chemotherapy could cause to decreased cell migration and/or induction of apoptosis. The effect of S1P4 on the tumor progression and the association with chemotherapy should be investigated in cancer cases.

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Sphingosine 1‐phosphate promotes cell migration through the activation of Cdc42 in Edg‐6/S1P4‐expressing cells

Abstract: AbstractsBackground : Sphingosine 1-phosphate (Sph-1-P) is a

Cited by 42 publications

References 35 publications

Calmodulin Is Involved in the Ca2+-dependent Activation of Ceramide Kinase as a Calcium Sensor

Calmodulin Is Involved in the Ca2+-dependent Activation of Ceramide Kinase as a Calcium Sensor

Involvement of Sphingosine Kinases/Sphingosine-1-Phosphate (S1P)/S1P Receptors in Breast Cancer Subtypes

Behavior of Sphingosine 1-Phosphate Receptor 4 Gene Expression in Patients with Neuroblastoma

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