Sphingosine-1-phosphate receptor 3 signaling

Li, Qian; Li, Yi; Cai, Lei; Tan, Ying; Yi, Guanghui

doi:10.1016/j.cca.2021.03.025

Cited by 22 publications

(25 citation statements)

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“…There are 5 S1PRs (S1PR1-5) with both unique and overlapping functions. Receptor expression varies based on cell type (Adada et al, 2013;Li et al, 2015;Li Q. et al, 2021). S1PR1-3 are the most commonly expressed subtypes and are present on endothelial cells (Adada et al, 2013;Li et al, 2015;Li Q. et al, 2021).…”

Section: Sphingolipid Pathwaymentioning

confidence: 99%

“…Receptor expression varies based on cell type (Adada et al, 2013;Li et al, 2015;Li Q. et al, 2021). S1PR1-3 are the most commonly expressed subtypes and are present on endothelial cells (Adada et al, 2013;Li et al, 2015;Li Q. et al, 2021). S1PR1 is critical for the mobilization of lymphocytes from lymphoid tissue and is also involved in angiogenesis, proinflammatory signaling, and maintenance of the endothelial barrier among other things (Adada et al, 2013;Li et al, 2015;Li Q. et al, 2021).…”

Section: Sphingolipid Pathwaymentioning

confidence: 99%

“…S1PR1-3 are the most commonly expressed subtypes and are present on endothelial cells (Adada et al, 2013;Li et al, 2015;Li Q. et al, 2021). S1PR1 is critical for the mobilization of lymphocytes from lymphoid tissue and is also involved in angiogenesis, proinflammatory signaling, and maintenance of the endothelial barrier among other things (Adada et al, 2013;Li et al, 2015;Li Q. et al, 2021). S1PR2 increases permeability of endothelial cell junctions, and is present in immune response, muscle function, and many organ systems (Adada et al, 2013;Li et al, 2015;Li Q. et al, 2021).…”

Section: Sphingolipid Pathwaymentioning

confidence: 99%

“…S1PR1 is critical for the mobilization of lymphocytes from lymphoid tissue and is also involved in angiogenesis, proinflammatory signaling, and maintenance of the endothelial barrier among other things (Adada et al, 2013;Li et al, 2015;Li Q. et al, 2021). S1PR2 increases permeability of endothelial cell junctions, and is present in immune response, muscle function, and many organ systems (Adada et al, 2013;Li et al, 2015;Li Q. et al, 2021). S1PR3 is essential for the immune response and is present on dendritic cells; it can replace S1PR1 function in the setting of low S1PR1 expression (Adada et al, 2013;Li et al, 2015;Li Q. et al, 2021).…”

Section: Sphingolipid Pathwaymentioning

confidence: 99%

See 3 more Smart Citations

Sphingolipids in Lung Pathology in the Coronavirus Disease Era: A Review of Sphingolipid Involvement in the Pathogenesis of Lung Damage

2021

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Sphingolipids are bioactive lipids involved in the regulation of cell survival, proliferation, and the inflammatory response. The SphK/S1P/S1PR pathway (S1P pathway) is a driver of many anti-apoptotic and proliferative processes. Pro-survival sphingolipid sphingosine-1-phosphate (S1P) initiates its signaling cascade by interacting with various sphingosine-1-phosphate receptors (S1PR) through which it is able to exert its pro-survival or inflammatory effects. Whereas sphingolipids, including ceramides and sphingosines are pro-apoptotic. The pro-apoptotic lipid, ceramide, can be produced de novo by ceramide synthases and converted to sphingosine by way of ceramidases. The balance of these antagonistic lipids and how this balance manifests is the essence of the sphingolipid rheostat. Recent studies on SARS-CoV-2 have implicated the S1P pathway in the pathogenesis of novel coronavirus disease COVID-19-related lung damage. Accumulating evidence indicates that an aberrant inflammatory process, known as “cytokine storm” causes lung injury in COVID-19, and studies have shown that the S1P pathway is involved in signaling this hyperinflammatory response. Beyond the influence of this pathway on cytokine storm, over the last decade the S1P pathway has been investigated for its role in a wide array of lung pathologies, including pulmonary fibrosis, pulmonary arterial hypertension (PAH), and lung cancer. Various studies have used S1P pathway modulators in models of lung disease; many of these efforts have yielded results that point to the potential efficacy of targeting this pathway for future treatment options. Additionally, they have emphasized S1P pathway’s significant role in inflammation, fibrosis, and a number of other endothelial and epithelial changes that contribute to lung damage. This review summarizes the S1P pathway’s involvement in COVID-19 and chronic lung diseases and discusses the potential for targeting S1P pathway as a therapeutic option for these diseases.

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Section: Sphingolipid Pathwaymentioning

confidence: 99%

Section: Sphingolipid Pathwaymentioning

confidence: 99%

Section: Sphingolipid Pathwaymentioning

confidence: 99%

Section: Sphingolipid Pathwaymentioning

confidence: 99%

See 2 more Smart Citations

Sphingolipids in Lung Pathology in the Coronavirus Disease Era: A Review of Sphingolipid Involvement in the Pathogenesis of Lung Damage

2021

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“…Lipids comprise a distinct class of small metabolic biomolecules with a diverse range of functions, including storage of energy [1,2], serving as major structural components of biological membranes [3][4][5], and participating in cellular signaling [6][7][8]. Lipidomics is a branch of analytical biochemistry that deals with the large-scale study of cellular lipids in biological systems.…”

Section: Introductionmentioning

confidence: 99%

A Novel Solid Phase Extraction Sample Preparation Method for Lipidomic Analysis of Human Plasma Using Liquid Chromatography/Mass Spectrometry

2021

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Lipidomic approaches are widely used to investigate the relationship between lipids, human health, and disease. Conventional sample preparation techniques for the extraction of lipids from biological matrices like human plasma are based on liquid-liquid extraction (LLE). However, these methods are labor-intensive, time-consuming, and can show poor reproducibility and selectivity on lipid extraction. A novel, solid-phase extraction (SPE) approach was demonstrated to extract lipids from human plasma using a lipid extraction SPE in both cartridge and 96-well-plate formats, followed by analysis using a combination of targeted and untargeted liquid chromatography/mass spectrometry. The Lipid Extraction SPE method was compared to traditional LLE methods for lipid class recovery, lipidome coverage, and reproducibility. The novel SPE method used a simplified protocol with significant time and labor savings and provided equivalent or better qualitative and quantitative results than traditional LLE methods with respect to several critical performance metrics; recovery, reproducibility, and lipidome coverage.

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Exploring the Lifeline: Unpacking the Complexities of Placental Vascular Function in Normal and Preeclamptic Pregnancies

Schliefsteiner,

Wadsack,

Allerkamp

2024

Comprehensive Physiology

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The proper development and function of the placenta are essential for the success of pregnancy and the well‐being of both the fetus and the mother. Placental vascular function facilitates efficient fetal development during pregnancy by ensuring adequate gas exchange with low vascular resistance. This review focuses on how placental vascular function can be compromised in the pregnancy pathology preeclampsia, and conversely, how placental vascular dysfunction might contribute to this condition. While the maternal endothelium is widely recognized as a key focus in preeclampsia research, this review emphasizes the importance of understanding how this condition affects the development and function of the fetal placental vasculature. The placental vascular bed, consisting of microvasculature and macrovasculature, is discussed in detail, as well as structural and functional changes associated with preeclampsia. The complexity of placental vascular reactivity and function, its mediators, its impact on placental exchange and blood distribution, and how these factors are most affected in early‐onset preeclampsia are further explored. These factors include foremost lipoproteins and their cargo, oxygen levels and oxidative stress, biomechanics, and shear stress. Challenges in studying placental pathophysiology are discussed, highlighting the necessity of innovative research methodologies, including ex vivo experiments, in vivo imaging tools, and computational modeling. Finally, an outlook on the potential of drug interventions targeting the placental endothelium to improve placental vascular function in preeclampsia is provided. Overall, this review highlights the need for further research and the development of models and tools to better understand and address the challenges posed by preeclampsia and its effects on placental vascular function to improve short‐ and long‐term outcomes for the offspring of preeclamptic pregnancies. © 2024 American Physiological Society. Compr Physiol 14:5763‐5787, 2024.

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Sphingosine-1-phosphate receptor 3 signaling

Cited by 22 publications

References 91 publications

Sphingolipids in Lung Pathology in the Coronavirus Disease Era: A Review of Sphingolipid Involvement in the Pathogenesis of Lung Damage

Sphingolipids in Lung Pathology in the Coronavirus Disease Era: A Review of Sphingolipid Involvement in the Pathogenesis of Lung Damage

A Novel Solid Phase Extraction Sample Preparation Method for Lipidomic Analysis of Human Plasma Using Liquid Chromatography/Mass Spectrometry

Exploring the Lifeline: Unpacking the Complexities of Placental Vascular Function in Normal and Preeclamptic Pregnancies

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