2007
DOI: 10.1182/blood-2006-08-041582
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Sphingosine 1-phosphate regulates peritoneal B-cell trafficking for subsequent intestinal IgA production

Abstract: Sphingosine 1-phosphate (S1P) is known to play a pivotal role in the regulation of lymphocyte emigration from organized lymphoid tissues such as the peripheral lymph nodes and thymus, but its immunologic role in unorganized and diffused tissues remains to be elucidated. Here we show that the trafficking of peritoneal B cells is principally regulated by S1P. All peritoneal B cells including B1a, B1b, and B2 B cells express comparable levels of the type 1 S1P receptor. Thus, treatment with FTY720, an S1P recepto… Show more

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Cited by 89 publications
(120 citation statements)
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“…S1P has received considerable attention in recent years as a regulator of lymphocyte trafficking [16]. For peritoneal B lymphocytes, S1P signalling is required for retention of B-lymphocytes within the peritoneum [11]. In agreement with a previous study [12], a moderate but significant migratory response of BALB/c peritoneal B cells towards S1P was observed (Fig.…”
Section: Resultssupporting
confidence: 89%
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“…S1P has received considerable attention in recent years as a regulator of lymphocyte trafficking [16]. For peritoneal B lymphocytes, S1P signalling is required for retention of B-lymphocytes within the peritoneum [11]. In agreement with a previous study [12], a moderate but significant migratory response of BALB/c peritoneal B cells towards S1P was observed (Fig.…”
Section: Resultssupporting
confidence: 89%
“…Antigen presentation assay NOD and BALB/c mice were immunised subcutaneously on the hind flank with 50 ÎŒg insulin peptide (Insulin B [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23]; Anaspec, San Jose, CA, USA). After 10 days, spleens were collected from these animals and splenic CD4 + T cells purified using CD4 MicroBeads (Miltenyi Biotec, Bergisch Gladbach, Germany).…”
Section: Methodsmentioning
confidence: 99%
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“…Interestingly, B cell lines derived from RA patients are uniquely resistant to Fas-mediated apoptosis, in part due to overactivity of SphK1 and overproduction of S1P, which can inhibit apoptosis and regulate lymphoid migratory pathways (26). Additionally, FTY720-phosphate, which binds to S1P receptors, caused the rapid disappearance of peritoneal B cells by inhibiting their emigration from parathymic lymph nodes, as well as reducing peritoneal B cell-derived intestinal secretory IgA production (46). This suggests that S1P may play an important role in regulating B cell survival, trafficking, and Ab production.…”
Section: Discussionmentioning
confidence: 99%
“…CD19 Ï© CD5 Ï© B cells in the peritoneal cavity and the gut lamina propria serve as an important source of IgA-producing plasma cells in response to various stimuli, contributing significantly to the response against enteric pathogens. 13,14 In both mice and humans, CD19 Ï©…”
Section: Cd5mentioning
confidence: 99%