Sphingosine 1-phosphate signaling during infection and immunity

Mohammed, Sabira; Bindu, Anu; Viswanathan, Arun; Harikumar, Kuzhuvelil B.

doi:10.1016/j.plipres.2023.101251

Cited by 14 publications

(4 citation statements)

References 250 publications

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“…Both the MMV and PS‐MMV induced the migration of BMDMs ( Figure 2 a and S8 ), which could be attributed to the inherent S1P expression in the MMV membrane. [ 47 ] Moreover, the average number of migrating BMDMs after S1P‐MMV, S1P‐PS‐MMV, and S1P‐PS‐MMV@SPD treatments were significantly higher than those after MMV or PS‐MMV treatments, suggesting that S1P modification could effectively recruit BMDMs.…”

Section: Resultsmentioning

confidence: 99%

Engineering Efferocytosis‐Mimicking Nanovesicles to Regulate Joint Anti‐Inflammation and Peripheral Immunosuppression for Rheumatoid Arthritis Therapy

Yuan,

Chai,

et al. 2024

Advanced Science

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Rheumatoid arthritis (RA) is an autoimmune disorder characterized by chronic inflammation of the synovial joints and the dysfunction of regulatory T cells (Tregs) in the peripheral blood. Therefore, an optimal treatment strategy should aim to eliminate the inflammatory response in the joints and simultaneously restore the immune tolerance of Tregs in peripheral blood. Accordingly, we developed an efferocytosis‐mimicking nanovesicle that contains three functional factors for immunomodulating of efferocytosis, including “find me” and “eat me” signals for professional (macrophage) or non‐professional phagocytes (T lymphocyte), and “apoptotic metabolite” for metabolite digestion. We showed that efferocytosis‐mimicking nanovesicles targeted the inflamed joints and spleen of mice with collagen‐induced arthritis, further recruiting and selectively binding to macrophages and T lymphocytes to induce M2 macrophage polarization and Treg differentiation and T helper cell 17 (Th17) recession. Under systemic administration, the efferocytosis‐mimicking nanovesicles effectively maintained the pro‐inflammatory M1/anti‐inflammatory M2 macrophage balance in joints and the Treg/Th17 imbalance in peripheral blood to prevent RA progression. This study demonstrates the potential of efferocytosis‐mimicking nanovesicles for RA immunotherapy.

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Section: Resultsmentioning

confidence: 99%

Engineering Efferocytosis‐Mimicking Nanovesicles to Regulate Joint Anti‐Inflammation and Peripheral Immunosuppression for Rheumatoid Arthritis Therapy

Yuan,

Chai,

et al. 2024

Advanced Science

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“…Respiratory infections are common triggers of AECOPD. The SphK/S1P axis has been reported to regulate the host immune system and to exert pro- or anti-viral effects in different types of viral infections by interfering with intracellular signaling pathways ( 56 , 57 ). For example, S1P can enhance endothelial barrier function and epithelial cell survival during respiratory syncytial virus infection by activating the Akt/ERK signaling pathway ( 58 , 59 ).…”

Section: Discussionmentioning

confidence: 99%

Serum metabolomics analysis of patients with chronic obstructive pulmonary disease and ‘frequent exacerbator’ phenotype

Ding,

Wang,

et al. 2024

Mol Med Rep

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“…Besides, intracellular S1P can serve as a second messenger and bind to intracellular targets. For example, S1P can bind with prohibitin-2 (PHB2) to affect mitochondrial respiration in the mitochondria [ 27 ] and combine with histone deacetylases to influence gene expression in the nucleus [ 28 ].…”

Section: Overview Of S1pmentioning

confidence: 99%

The role of sphingosine-1-phosphate in autophagy and related disorders

Xiao,

Peng,

et al. 2023

Cell Death Discov.

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S1P, also referred to as sphingosine-1-phosphate, is a lipid molecule with bioactive properties involved in numerous cellular processes such as cell growth, movement, programmed cell death, self-degradation, cell specialization, aging, and immune system reactions. Autophagy is a meticulously controlled mechanism in which cells repurpose their elements to maintain cellular balance. There are five stages in autophagy: initiation, nucleation, elongation and maturation, fusion, and degradation. New research has provided insight into the complex connection between S1P and autophagy, uncovering their interaction in both normal and abnormal circumstances. Gaining knowledge about the regulatory mechanism of S1P signaling on autophagy can offer a valuable understanding of its function in well-being and illness, potentially leading to innovative therapeutic concepts for diverse ailments. Hence, this review analyzes the essential stages in mammalian autophagy, with a specific emphasis on recent research exploring the control of each stage by S1P. Additionally, it sheds light on the roles of S1P-induced autophagy in various disorders.

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Sphingosine 1-phosphate signaling during infection and immunity

Cited by 14 publications

References 250 publications

Engineering Efferocytosis‐Mimicking Nanovesicles to Regulate Joint Anti‐Inflammation and Peripheral Immunosuppression for Rheumatoid Arthritis Therapy

Engineering Efferocytosis‐Mimicking Nanovesicles to Regulate Joint Anti‐Inflammation and Peripheral Immunosuppression for Rheumatoid Arthritis Therapy

Serum metabolomics analysis of patients with chronic obstructive pulmonary disease and ‘frequent exacerbator’ phenotype

The role of sphingosine-1-phosphate in autophagy and related disorders

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