2013
DOI: 10.1189/jlb.0712328
|View full text |Cite
|
Sign up to set email alerts
|

Sphingosine-1-phosphate suppresses TLR-induced CXCL8 secretion from human T cells

Abstract: T cells produce a number of cytokines and chemokines upon stimulation with TLR agonists in the presence or absence of TCR signals. Here, we show that secretion of neutrophil chemoattractant CXCL8 from human T cell line Jurkat in response to stimulation with TLR agonists is reduced when cell stimulation is carried out in presence of serum. Serum does not, however, inhibit TCR-activated secretion of CXCL8 nor does it down-regulate TLR-costimulated IL-2 secretion from activated T cells. The molecule that can mimi… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

2
26
0

Year Published

2014
2014
2020
2020

Publication Types

Select...
6
2

Relationship

2
6

Authors

Journals

citations
Cited by 47 publications
(28 citation statements)
references
References 34 publications
2
26
0
Order By: Relevance
“…Several studies have shown that TLRs on T cells can costimulate cytokine responses triggered through the TCR . Microbial TLR ligands have also been shown to activate T cells independent of TCR signals . Whether T‐cell activation through the antigen receptor modulates T‐cell responses generated through activation of TLRs has not been investigated.…”
Section: Introductionmentioning
confidence: 99%
“…Several studies have shown that TLRs on T cells can costimulate cytokine responses triggered through the TCR . Microbial TLR ligands have also been shown to activate T cells independent of TCR signals . Whether T‐cell activation through the antigen receptor modulates T‐cell responses generated through activation of TLRs has not been investigated.…”
Section: Introductionmentioning
confidence: 99%
“…Previously, we and others demonstrated that human CD4 + T lymphocytes themselves produce CXCL8 upon activation (8,16). Therefore, we investigated whether sorted zebrafish T lymphocytes also express cxcl8-l1 and/or cxcl8-l2.…”
Section: Increased Intestinal Cxcl8 Expression At 5 Wpf Associates Wimentioning
confidence: 99%
“…Likewise, T cell-derived IL-17A and IL-17F were capable to either directly or indirectly induce CXCL8 expression in airway and retinal pigment epithelial cells (13,14). Moreover, evidence exists that human T cells themselves are capable of producing cytokines such as CXCL8 after TLR stimulation (15)(16)(17). In vivo research into CXCL8 function and regulation has been hampered by the lack of appropriate animal models.…”
mentioning
confidence: 99%
“…In particular, cooperation of TLRs with S1PRs has been demonstrated in immune and non-immune cells. In macrophages and T cells, S1P attenuates TLR2 signaling and TLRinduced IL-8 production, respectively [39,40]. In contrast, S1P and TLR4 cooperatively induce pro-inflammatory cytokine expression and type I IFNs in gingival epithelial and endothelial cells [28,29,41].…”
Section: Discussionmentioning
confidence: 89%