“…In this study, we have tested the hypothesis that SphK1-derived S1P contributes to pulmonary vascular remodeling in PAH by promoting PASMC proliferation. Some of these data have been reported in abstract form (13)(14)(15)(16).…”
The SphK1/S1P axis is a novel pathway in PAH that promotes PASMC proliferation, a major contributor to pulmonary vascular remodeling. Our results suggest that this pathway is a potential therapeutic target in PAH.
“…In this study, we have tested the hypothesis that SphK1-derived S1P contributes to pulmonary vascular remodeling in PAH by promoting PASMC proliferation. Some of these data have been reported in abstract form (13)(14)(15)(16).…”
The SphK1/S1P axis is a novel pathway in PAH that promotes PASMC proliferation, a major contributor to pulmonary vascular remodeling. Our results suggest that this pathway is a potential therapeutic target in PAH.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.