Sphingosine kinase 1 is required for myristate-induced TNFα expression in intestinal epithelial cells

Choi, Songhwa; Snider, Justin; Cariello, Chris P.; Lambert, Johana M.; Anderson, Andrea; Cowart, L. Ashley; Snider, Ashley J.

doi:10.1016/j.prostaglandins.2020.106423

Cited by 9 publications

(21 citation statements)

References 36 publications

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“…1 and Table 1 . High levels of FFA, especially saturated FFA can be cytotoxic 30,31 and ceramide is an apoptotic signal in cells 32,33 . Ceramide is an agonist of Toll-like receptor TLR 4, and TLR4 signaling is thought to enhance the incidence of colon inflammation and cancer 34,35 .…”

Section: Discussionmentioning

confidence: 99%

“…In addition, sphingoid base composition from plants could exert a different effect than those from animals. Moreover, saturated FFA activates sphingosine kinase which exchanges sphingosine from ceramide for sphingosine 1-phosphate, and sphingosine 1-phosphate is thought to induce chronic inflammation and colon cancer 31,39 . Overall, we are of the opinion that high FFA and/or ceramide concentrations in SL adversely affect the intestinal conditions.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Dietary Ethanol Extracts from Sake Rice and Sake Lees on Intestinal Impairment in Mice

et al. 2020

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Introduction Complex sphingolipids are composed of a sphingoid base with an amide-linked fatty acid i.e., ceramide, Cer and a polar head group, such as a phosphocholine or a hexose 1. Sphingolipids are primarily found in the cell membrane of most eukaryotes and some prokaryotes. The compositions of the classes and sphingoid bases are highly diverse in nature. Mammalian sphingolipid classes consist of sphingomyelin, galactocylceramide, Cer, and ganglioside. In contrast, plant and fungal sphingolipid classes are mainly composed of glucosylceramide GlcCer , Cer, inositol phosphoceramide IPC , and glycosyl IPC GIPC. In the mammalian sphingolipids, trans-4-sphingenine sphingosine, d18:1 4t is the most prevalent sphingoid base; whereas sphinganine d18:0 and 4-hydroxysphinganine phytosphingosine, t18:0 also occur frequently in smaller amounts.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of Dietary Ethanol Extracts from Sake Rice and Sake Lees on Intestinal Impairment in Mice

et al. 2020

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“…RNA extraction and quantitative real-time PCR in tumor tissues were performed as described in Choi et al [ 26 ]. The following TaqMan probes (Thermo Fisher Scientific, Waltham, MA, USA) were used: mouse S1PR1 (ID: Mm02619656_s1), mouse TNFα (ID: Mm00443260_g1), mouse MMP9 (ID: Mm00442991_m1), and mouse β-actin (ID: Mm02619580_g1).…”

Section: Methodsmentioning

confidence: 99%

A Milk-Fat Based Diet Increases Metastasis in the MMTV-PyMT Mouse Model of Breast Cancer

et al. 2021

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A high-fat diet (HFD) and obesity are risk factors for many diseases including breast cancer. This is particularly important with close to 40% of the current adult population being overweight or obese. Previous studies have implicated that Mediterranean diets (MDs) partially protect against breast cancer. However, to date, the links between diet and breast cancer progression are not well defined. Therefore, to begin to define and assess this, we used an isocaloric control diet (CD) and two HFDs enriched with either olive oil (OOBD, high in oleate, and unsaturated fatty acid in MDs) or a milk fat-based diet (MFBD, high in palmitate and myristate, saturated fatty acids in Western diets) in a mammary polyomavirus middle T antigen mouse model (MMTV-PyMT) of breast cancer. Our data demonstrate that neither MFBD or OOBD altered the growth of primary tumors in the MMTV-PyMT mice. The examination of lung metastases revealed that OOBD mice exhibited fewer surface nodules and smaller metastases when compared to MFBD and CD mice. These data suggest that different fatty acids found in different sources of HFDs may alter breast cancer metastasis.

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“…In a SphK1-knockout model, mice showed partial resistance to chemically induced colitis, and in cancer-associated colitis, significant attenuation of colon cancer was achieved [100]. Recently, it was suggested that SFA in the diet directly stimulates SphK1 inflammatory responses (COX2, TNFα, JNK) bypassing the need for S1P and S1PR activation, as demonstrated in intestinal epithelial cells [142]. In vitro studies also support the promotion of the epithelial-mesenchymal transition in colon cancers by SphK1 mediating the focal adhesion, protein kinase B (AKT), and matrix metalloproteinase (MMP)2/9 pathway [143].…”

Section: S1p and Small Intestine/colorectal/anal Cancersmentioning

confidence: 99%

Targeting Chronic Inflammation of the Digestive System in Cancer Prevention: Modulators of the Bioactive Sphingolipid Sphingosine-1-Phosphate Pathway

McGowan

Lin

Chen

2022

Cancers

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Incidence of gastrointestinal (GI) cancers is increasing, and late-stage diagnosis makes these cancers difficult to treat. Chronic and low-grade inflammation are recognized risks for most GI cancers. The GI mucosal immune system maintains healthy homeostasis and signalling molecules made from saturated fats, bioactive sphingolipids, play essential roles in healthy GI immunity. Sphingosine-1-phosphate (S1P), a bioactive sphingolipid, is a key mediator in a balanced GI immune response. Disruption in the S1P pathway underlies systemic chronic metabolic inflammatory disorders, including diabetes and GI cancers, providing a strong rationale for using modulators of the S1P pathway to treat pathological inflammation. Here, we discuss the effects of bioactive sphingolipids in immune homeostasis with a focus on S1P in chronic low-grade inflammation associated with increased risk of GI carcinogenesis. Contemporary information on S1P signalling involvement in cancers of the digestive system, from top to bottom, is reviewed. Further, we discuss the use of novel S1P receptor modulators currently in clinical trials and their potential as first-line drugs in the clinic for chronic inflammatory diseases. Recently, ozanimod (ZeposiaTM) and etrasimod have been approved for clinical use to treat ulcerative colitis and eosinophilic oesophagitis, respectively, which may have longer term benefits in reducing risk of GI cancers.

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Sphingosine kinase 1 is required for myristate-induced TNFα expression in intestinal epithelial cells

Cited by 9 publications

References 36 publications

Effects of Dietary Ethanol Extracts from Sake Rice and Sake Lees on Intestinal Impairment in Mice

Effects of Dietary Ethanol Extracts from Sake Rice and Sake Lees on Intestinal Impairment in Mice

A Milk-Fat Based Diet Increases Metastasis in the MMTV-PyMT Mouse Model of Breast Cancer

Targeting Chronic Inflammation of the Digestive System in Cancer Prevention: Modulators of the Bioactive Sphingolipid Sphingosine-1-Phosphate Pathway

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