Spi-B is critical for plasmacytoid dendritic cell function and development

Sasaki, Izumi; Hoshino, Katsuaki; Sugiyama, Takahiro; Yamazaki, C.; Yano, Takahiro; Iizuka, Akihiko; Hemmi, Hiroaki; Tanaka, Takashi; Saito, Masuyoshi; Sugiyama, Masanaka; Fukuda, Yuri; Ohta, Tomokazu; Sato, Katsuaki; Ainai, Akira; Suzuki, Tadaki; Hasegawa, Hideki; Toyama–Sorimachi, Noriko; Kohara, Hiroshi; Nagasawa, Takashi; Kaisho, Tsuneyasu

doi:10.1182/blood-2012-06-436527

Cited by 79 publications

(82 citation statements)

References 47 publications

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“…Cluster 33 is enriched in plasmacytoid dendritic cells (pDC) and contains TLR9, known to be pDC-restricted in humans, and the pDC transcription factors IRF4 and SPIB [50], again consistent with previous mouse data [2]. It is not our purpose to annotate all of the clusters processively.…”

Section: Resultssupporting

confidence: 69%

An expression atlas of human primary cells: inference of gene function from coexpression networks

et al. 2013

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BackgroundThe specialisation of mammalian cells in time and space requires genes associated with specific pathways and functions to be co-ordinately expressed. Here we have combined a large number of publically available microarray datasets derived from human primary cells and analysed large correlation graphs of these data.ResultsUsing the network analysis tool BioLayout Express3D we identify robust co-associations of genes expressed in a wide variety of cell lineages. We discuss the biological significance of a number of these associations, in particular the coexpression of key transcription factors with the genes that they are likely to control.ConclusionsWe consider the regulation of genes in human primary cells and specifically in the human mononuclear phagocyte system. Of particular note is the fact that these data do not support the identity of putative markers of antigen-presenting dendritic cells, nor classification of M1 and M2 activation states, a current subject of debate within immunological field. We have provided this data resource on the BioGPS web site (http://biogps.org/dataset/2429/primary-cell-atlas/) and on macrophages.com (http://www.macrophages.com/hu-cell-atlas).

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Section: Resultssupporting

confidence: 69%

An expression atlas of human primary cells: inference of gene function from coexpression networks

et al. 2013

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“…pDC numbers are reduced in the bone marrow of Spib −/− mice but are increased in the periphery, suggesting impaired retention in the bone marrow 59 . Furthermore, Spib −/− pDCs exhibit attenuated expression of pDC-specific genes and display defects in type I IFN production following TLR7 or TLR9 stimulation.…”

Section: Development Of Pdcsmentioning

confidence: 99%

The multifaceted biology of plasmacytoid dendritic cells

2015

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Plasmacytoid dendritic cells (pDCs) are a unique dendritic cell subset that specializes in the production of type I interferons (IFNs). pDCs promote antiviral immune responses and have been implicated in the pathogenesis of autoimmune diseases characterized by a type I IFN signature. However, pDCs can also induce tolerogenic immune responses. Here, we review recent progress from the field of pDC biology, focusing on: the molecular mechanisms that regulate pDC development and functions; the pathways involved in their sensing of pathogens and endogenous nucleic acids; the function of pDCs at mucosal sites; and their roles in infections, autoimmunity and cancer.

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“…However, Spi-B does not express in lymphoid cells (neuthrophils and monocytes) (Chen et al, 1995) because it prevents differentiation of hematopoietic progenitor cells toward the lymphoid lineage (Schotte et al, 2003). Spi-B is critical for development and function of both mouse (Sasaki et al, 2012) and human (Schotte et al, 2004) pDCs. E2-2 and Spi-B cooperate in stimulating pDC differentiation in order to overcome Id2 enforced block in pDC development (Nagasawa et al, 2008).…”

Section: Transciption and Growth Factors Driving Differentiation Of Pdcsmentioning

confidence: 99%

“…E2-2 and Spi-B cooperate in stimulating pDC differentiation in order to overcome Id2 enforced block in pDC development (Nagasawa et al, 2008). In synergy with IRF7, Spi-B activates expression of IFN-I in pDCs (Sasaki et al, 2012). Finally, Spi-B supports survival of pDCs and their precursors by up-regulating expression of anti-apoptotic protein Bcl2-A1 (Karrich et al, 2012).…”

Section: Transciption and Growth Factors Driving Differentiation Of Pdcsmentioning

confidence: 99%

Plasmacytoid dendritic cells: development, functions, and role in atherosclerotic inflammation

et al. 2014

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Plasmacytoid dendritic cells (pDCs) are a specialized subset of DCs that links innate and adaptive immunity. They sense viral and bacterial pathogens and release high levels of Type I interferons (IFN-I) in response to infection. pDCs were shown to contribute to inflammatory responses in the steady state and in pathology. In atherosclerosis, pDCs are involved in priming vascular inflammation and atherogenesis through production of IFN-I and chemokines that attract inflammatory cells to inflamed sites. pDCs also contribute to the proinflammatory activation of effector T cells, cytotoxic T cells, and conventional DCs. However, tolerogenic populations of pDCs are found that suppress atherosclerosis-associated inflammation through down-regulation of function and proliferation of proinflammatory T cell subsets and induction of regulatory T cells with potent immunomodulatory properties. Notably, atheroprotective tolerogenic DCs could be induced by certain self-antigens or bacterial antigens that suggests for great therapeutic potential of these DCs for development of DC-based anti-atherogenic vaccines.

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Spi-B is critical for plasmacytoid dendritic cell function and development

Cited by 79 publications

References 47 publications

An expression atlas of human primary cells: inference of gene function from coexpression networks

An expression atlas of human primary cells: inference of gene function from coexpression networks

The multifaceted biology of plasmacytoid dendritic cells

Plasmacytoid dendritic cells: development, functions, and role in atherosclerotic inflammation

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