SPIB acts as a tumor suppressor by activating the NFkB and JNK signaling pathways through MAP4K1 in colorectal cancer cells

Zhao, Xunping; Li, Lin; Yuan, Shiyun; Qia, Zhang; Jiang, Xupin; Luo, Tao

doi:10.1016/j.cellsig.2021.110148

Cited by 23 publications

(11 citation statements)

References 32 publications

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“…These results are consistent with previous studies that SPIB is essential in protective humoral immunity [4]. In addition, SPIB has been associated with tumor suppression via NFkappa B signaling pathway [8], consistent with our study findings.…”

Section: Discussionsupporting

confidence: 94%

“…An increasing body of evidence from recently published studies suggests that SPIB plays an important role in tumor development. For instance, SPIB reportedly exerts an inhibitory effect in colorectal cancer cells by activating NFkB and JNK signaling through MAP4K1 [ 8 ] and promotes tumor-associated macrophage (TAM) recruitment by enhancing the expression of CCL4 in lung cancer [ 9 ]. Moreover, SPIB plays an important role in the abnormal switch reorganization of ABC DLBCL [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

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Comprehensive pan-cancer analysis reveals the prognostic value and immunological role of SPIB

Ding

Tan

et al. 2022

Aging

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It is well-established that SPIB is essential for the survival of mature B cells, playing a key role in diffuse large B-cell lymphoma, colorectal cancer, and lung cancer. However, no study has hitherto conducted a systematic pan-cancer analysis on SPIB. Herein, we analyzed the differential expression of SPIB in pan-cancer using The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) databases and found that SPIB was significantly upregulated in most cancers. In addition, SPIB was positively or negatively associated with prognosis in different cancers. We found that SPIB was significantly associated with tumor immune infiltration and immune checkpoint genes in more than 35 tumors by TIMER database analysis. In addition, SPIB was negatively correlated with Tumor mutational burden (TMB) and Microsatellite instability (MSI) in most tumors. Finally, GO/KEGG enrichment analysis revealed the possible involvement of SPIB in NF-kappa B and B-cell receptor signaling pathways. In conclusion, our comprehensive pan-cancer analysis of SPIB reveals its important role in tumor immunity, suggesting it has huge prospects for clinical application in cancer therapy.

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Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Comprehensive pan-cancer analysis reveals the prognostic value and immunological role of SPIB

Ding

Tan

et al. 2022

Aging

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“…Subnetwork A was the primary driver behind the previously noted thymus-specific high expression of inflammatory response pathway regulons, connecting the interferon response factor regulons IRF1, IRF7, IRF8, IRF9 with an even larger number of STAT family regulons ( STAT5A, STAT3, STAT2 and STAT1), NF- family subunit regulons NFKB1, NFKB2 and RELB, and the NF- SPIB 45 , HIVEP1 46 . Interferon (IFNs) are a family of cytokines known to induce cell intrinsic programs with antiviral, immunomodulatory and antiproliferative properties 47 .…”

Section: Resultsmentioning

confidence: 94%

Development in context: interferon response networks regulate human fetal thymic epithelial cell differentiation

Mohammed

Slepicka

Solomon

et al. 2022

Preprint

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The thymus is the primary lymphoid organ that instructs adaptive T cell immunity and central tolerance. Within the thymus, the thymic epithelium comprises a diverse and highly specialized set of cells that promote T cell maturation, proliferation, and selection of a diverse and self-tolerant T cell receptor repertoire. As such, the function of the thymic epithelium is central to the integrity of the immune system in health and disease and regenerating thymic function holds great therapeutic promise. However, the gene regulatory networks that drive thymic epithelial cell ontogeny and maintenance during human embryonic development remain incompletely understood. Elucidating the complex interplay between cell intrinsic and environmental signals that contribute to thymic morphogenesis is essential to derive thymic epithelial cells from pluripotent stem cells to reconstitute thymic function for therapeutic purposes. To deduce the signals instructing the development and specialization of the human thymic epithelial stroma, we have used a dual single cell transcriptomic approach: A, To dissect lineage bifurcations on the trajectory towards thymic fate, we have compared transcriptional signatures of epithelial cells from human fetal thymus to epithelial cells derived from the other major anterior foregut-derived organs, i.e., bronchus, lung, and esophagus as well as the parathyroid. B, To define the proliferative dynamics that give rise to developmental hierarchies within specialized thymic epithelial compartments, we have compared human thymus samples sequentially during embryonic, fetal, and early postnatal stages of organogenesis. Distinct gene regulatory patterns delineate cortical, and medullary thymic epithelial cells, conducting airway basal cells, respiratory bud-tip progenitor cells and esophageal basal cells. Specifically, the transcription factors SOX2 and TP63, that promote basal epithelial cell fate when co-expressed and drive branching morphogenesis when cycled in a coordinated fashion, show a uniquely divergent TP63highSOX2low expression pattern in the thymic epithelium. In addition, the thymic epithelium shows distinctive interferon and NFkb-driven signature which is not present in other epithelial cells. Within the thymic epithelial compartments, a cycling progenitor pool gives rise to three distinct developmental trajectories. A dichotomy between PI3Kinase and TGFb signaling between cTECs and mTECs was observed. Our studies map gene regulatory signatures during thymic epithelial cell ontogeny with the intent to advance directed differentiation approaches for translational applications.

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“…The high expression of FOXJ1 was found to be associated with better disease-free survival, and it may be a good prognostic factor for BRCA (41). Little is known about the role of SPIB in BRCA, but research has shown that it exerts anti-cancer effects in colorectal cancer (42). LEF1 is regarded as a potential biomarker for the metastasis of BRCA (43).…”

Section: Discussionmentioning

confidence: 99%

Identification and validation of a novel prognostic signature based on transcription factors in breast cancer by bioinformatics analysis

Yang¹,

Li²,

Zhao³

et al. 2022

Gland Surg

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Background: Breast cancer (BRCA) is the leading cause of cancer mortality among women, and it is associated with many tumor suppressors and oncogenes. There is increasing evidence that transcription factors (TFs) play vital roles in human malignancies, but TFs-based biomarkers for BRCA prognosis were still rare and necessary. This study sought to develop and validate a prognostic model based on TFs for BRCA patients.Methods: Differentially expressed TFs were screened from 1,109 BRCA and 113 non-tumor samples downloaded from The Cancer Genome Atlas (TCGA). Univariate Cox regression analysis was used to identify TFs associated with overall survival (OS) of BRCA, and multivariate Cox regression analysis was performed to establish the optimal risk model. The predictive value of the TF model was established using TCGA database and validated using a Gene Expression Omnibus (GEO) data set (GSE20685). A gene set enrichment analysis was conducted to identify the enriched signaling pathways in high-risk and low-risk BRCA patients. Gene Ontology (GO) function and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses of the TF target genes were also conducted separately.

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SPIB acts as a tumor suppressor by activating the NFkB and JNK signaling pathways through MAP4K1 in colorectal cancer cells

Cited by 23 publications

References 32 publications

Comprehensive pan-cancer analysis reveals the prognostic value and immunological role of SPIB

Comprehensive pan-cancer analysis reveals the prognostic value and immunological role of SPIB

Development in context: interferon response networks regulate human fetal thymic epithelial cell differentiation

Identification and validation of a novel prognostic signature based on transcription factors in breast cancer by bioinformatics analysis

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