Spice up your food for cancer prevention: Cancer chemo-prevention by natural compounds from common dietary spices

Gao, Jie; Mamouni, Kenza; Zhang, Lei; Lokeshwar, Bal L.

doi:10.1016/b978-0-12-821710-8.00013-8

Cited by 8 publications

(6 citation statements)

References 232 publications

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“…Moreover, spices are generally recommended for adults with CKD for flavor enhancement of cuisines when reducing sodium [ 39 , 40 ]. Even though 66.2% of participants within this study reported having hypertension, no positive correlations were observed with frequency of spice consumption or variety of spices consumed, yet more with negative associations, which likely were related to avoiding seasonings/spices with high salt content.…”

Section: Resultsmentioning

confidence: 99%

Associations between diet quality, demographics, health conditions and spice and herb intake of adults with chronic kidney disease

Hammer,

Acevedo,

Andrade

2024

PLoS ONE

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Scant literature has been able to demonstrate an association between dietary habits and spice and herb consumption, especially for those who have chronic kidney disease. The objectives of this study were to 1) determine the frequency and quantity of spices and herbs consumed and 2) determine the associations between diet quality and its food components, demographics, and health conditions with spice and herb frequency and variety consumption of adults with chronic kidney disease. A cross-sectional online study was conducted with adults with various stages of chronic kidney disease (n = 71). Participants responded to an online demographic, diet and spice and herb questionnaire on RedCap. Diet quality was determined through the diet questionnaire. Descriptives, frequencies and Spearman correlations were conducted using SPSS v28 with a significance of p<0.05. Most participants were in chronic kidney disease stage 3 (42.3%) with a majority (98.6%) self-identifying as non-Hispanic white. On average, participants consumed black pepper more than once daily (47.9%) with the spice quantity at 5 g. The median diet quality score was 38.5 (range 31.5–48.5). Positive associations were identified with overall diet quality scores and certain spices such as basil (r = 0.33; p<0.01) and cinnamon (r = 0.37; p<0.002). Further associations were seen with food groups, self-identifying as white and health conditions with spice frequency and variety of spices and herbs consumed. Overall, positive associations were observed with diet quality and spice and herb intake, in which higher diet quality scores would indicate higher consumption of spices and herbs. Further research should focus on diet quality and spice and herb consumption in reducing progression of this disease.

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Section: Resultsmentioning

confidence: 99%

Associations between diet quality, demographics, health conditions and spice and herb intake of adults with chronic kidney disease

Hammer,

Acevedo,

Andrade

2024

PLoS ONE

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“…Extracts from natural products contain multiple molecular components. These c ponents may interact with each other during synthesis in addition to the reaction prod This is different from the process that uses industrial chemicals with only one wel fined reagent, which might be of an advantage or disadvantage for the final nanoprod Gao et al [25] report that the cinnamon extract contains several active ingredients, inc ing eugenol (Figure 2b), cinnamaldehyde (Figure 2c), cinnamic acid and coumarin pending on the part of the plant from which it was obtained.…”

Section: Preview Of the Course Of The Reactionmentioning

confidence: 99%

Synthesis of Gold Clusters and Nanoparticles Using Cinnamon Extract—A Mechanism and Kinetics Study

Luty-Błocho,

Cyndrowska,

Rutkowski

et al. 2024

Molecules

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In this work, UV-Vis spectrophotometry, High Resolution Scanning Transmission Electron Microscopes and selected experimental conditions were used to screen the colloidal system. The obtained results complement the established knowledge regarding the mechanism of nanoparticle formation. The process of gold nanoparticles formation involves a two-step reduction of Au ions to Au(0); atom association and metastable cluster formation; autocatalytic cluster growth; ultra-small particle formation (1–2 nm, in diameter); particle growth and larger particles formation; and further autocatalytic crystal growth (D > 100 nm). As a reductant of Au(III) ions, a cinnamon extract was used. It was confirmed that eugenol as one of the cinnamon extract compounds is responsible for fast Au(III) ion reduction, whereas cinnamaldehyde acts as a gold-particle stabilizer. Spectrophotometry studies were carried out to track kinetic traces of gold nanoparticle (D > 2 nm) formation in the colloidal solution. Using the Watzky—Finke model, the rate constants of nucleation and autocatalytic growth were determined. Moreover, the values of energy, enthalpy and entropy of activation for stages related to the process of nanoparticle formation (Index 1 relates to nucleation, and Index 2 relates to the growth) were determined and found to be E1 = 70.6 kJ, E2 = 19.6 kJ, ΔH1 = 67.9 kJ/mol, ΔH2 = 17 kJ/mol, ΔS1 = −76.2 J/(K·mol), ΔS2 = −204.2 J/(K·mol), respectively. In this work the limitation of each technique (spectrophotometry vs. HRSTEM) as a complex tool to understand the dynamic of the colloidal system was discussed.

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“…Triterpenoids are also isolated from invertebrates [ 59 , 60 ], and fungi [ 61 ]. Due to their multiple biological activities, triterpenoids are extensively evaluated for their potential use in human pathophysiology [ 62 , 63 ]. Triterpenoids are synthesized from IPP via the 30-carbon intermediate squalene and include sterols, steroids, and triterpenoid saponins [ 64 ].…”

Section: Targeting Mitochondrial Metabolism Of Prostate Cancer Witmentioning

confidence: 99%

Targeting Mitochondrial Metabolism in Prostate Cancer with Triterpenoids

Mamouni

Kallifatidis

Lokeshwar

2021

IJMS

Self Cite

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Metabolic reprogramming is a hallmark of malignancy. It implements profound metabolic changes to sustain cancer cell survival and proliferation. Although the Warburg effect is a common feature of metabolic reprogramming, recent studies have revealed that tumor cells also depend on mitochondrial metabolism. Due to the essential role of mitochondria in metabolism and cell survival, targeting mitochondria in cancer cells is an attractive therapeutic strategy. However, the metabolic flexibility of cancer cells may enable the upregulation of compensatory pathways, such as glycolysis, to support cancer cell survival when mitochondrial metabolism is inhibited. Thus, compounds capable of targeting both mitochondrial metabolism and glycolysis may help overcome such resistance mechanisms. Normal prostate epithelial cells have a distinct metabolism as they use glucose to sustain physiological citrate secretion. During the transformation process, prostate cancer cells consume citrate to mainly power oxidative phosphorylation and fuel lipogenesis. A growing number of studies have assessed the impact of triterpenoids on prostate cancer metabolism, underlining their ability to hit different metabolic targets. In this review, we critically assess the metabolic transformations occurring in prostate cancer cells. We will then address the opportunities and challenges in using triterpenoids as modulators of prostate cancer cell metabolism.

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Spice up your food for cancer prevention: Cancer chemo-prevention by natural compounds from common dietary spices

Cited by 8 publications

References 232 publications

Associations between diet quality, demographics, health conditions and spice and herb intake of adults with chronic kidney disease

Associations between diet quality, demographics, health conditions and spice and herb intake of adults with chronic kidney disease

Synthesis of Gold Clusters and Nanoparticles Using Cinnamon Extract—A Mechanism and Kinetics Study

Targeting Mitochondrial Metabolism in Prostate Cancer with Triterpenoids

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