Spiculated periosteal reaction in metastatic lesions of bone

Vilar, J.; Lezana, A Hernández; Pedrosa, C. S.

doi:10.1007/bf00360941

Cited by 19 publications

(7 citation statements)

References 2 publications

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“…When both findings are present, the leading diagnoses are osteosarcoma or chondrosarcoma of the rib. Rarely, metastatic carcinoma to the rib may simulate this appearance [6]. CT also facilitates treatment planning, because of its ability to delineate involvement of adjacent structures such as lung, diaphragm, and neurovascular elements preoperatively.…”

Section: Discussionmentioning

confidence: 97%

Primary osteosarcoma of the ribs: CT findings

et al. 1995

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Section: Discussionmentioning

confidence: 97%

Primary osteosarcoma of the ribs: CT findings

et al. 1995

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“…In human medicine, periosteal reactions encompass different abnormal bone geometries. The ones involving bone spicules radiating from the bone surface (spiculated periosteal reactive bone, SPRB) are caused most of the time by aggressive conditions or malignancy: Ewing's sarcoma, osteosarcoma, osteomyelitis, leukaemia, lymphoma and more rarely osteoblastic metastases from the prostate, gastrointestinal tract and lung, among others [7,12,13,[30][31][32][33][34]. SPRB is deposited along the vascular canals and Sharpey's fibres because they are stretched out between the detached periosteum and the cortex, resulting in that spiculated appearance that is roughly perpendicular to the periosteal surface.…”

Section: Discussion (A) Histological Ontogenetic Stages and Remodelling Frontmentioning

confidence: 99%

“…When comparing fossil bones with the abundant body of work in the human medical literature, it is obvious that radiography is used more routinely than histology or high-resolution scanning (e.g. [30][31][32]). This limits our inference power in fossils where the cause of the reaction is not preserved elsewhere in the skeleton.…”

Section: Discussion (A) Histological Ontogenetic Stages and Remodelling Frontmentioning

confidence: 99%

Case study of radial fibrolamellar bone tissues in the outer cortex of basal sauropods

Jentgen-Ceschino

Stein

Fischer

2020

Phil. Trans. R. Soc. B

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The histology of sauropod long bones often appears uniform and conservative along their evolutionary tree. One of the main aspects of their bone histology is to exhibit a fibrolamellar complex in the cortex of their long bones. Here, we report another bone tissue, the radial fibrolamellar bone (RFB), in the outer cortex of the humeri of a young adult cf. Isanosaurus (Early to Late Jurassic, Thailand) and an adult Spinophorosaurus nigerensis (Early to Middle Jurassic, Niger) that do not exhibit any pathological feature on the bone surface. Its location within the cortex is unexpected, because RFB is a rapidly deposited bone tissue that would rather be expected early in the ontogeny. A palaeopathological survey was conducted for these sampled specimens. Observed RFB occurrences are regarded as spiculated periosteal reactive bone, which is an aggressive form of periosteal reaction. A ‘hair-on-end’ pattern of neoplasmic origin (resembling a Ewing's sarcoma) is favoured for cf. Isanosaurus , while a sunburst pattern of viral or neoplasmic origin (resembling an avian osteopetrosis or haemangioma) is favoured for Spinophorosaurus . This study highlights the importance of bone histology in assessing the frequency and nature of palaeopathologies. This article is part of the theme issue ‘Vertebrate palaeophysiology’.

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“…Vilar [ 8 ] summarized six cases of metastatic bone tumor and stated that bone metastasis should be included in differential diagnosis of perpendicular periosteal reaction at 40-years-old or older. Lehrer [ 7 ] also reported five similar cases where the primary lesion was retinoblastomas in two cases, prostatic carcinoma in one case, tumor of undetermined primary origin (probably bronchogenic) in one case, and chloromatous acute myelocytic leukemia in one case.…”

Section: Discussionmentioning

confidence: 99%

An Ancient Skeleton with Multiple Osteoblastic Bone Lesions Containing a Scapular Sunburst Appearance from a 5th–6th Century Grave Excavated in Oita, Japan

Tsurumoto

Wakebe

Ogami-Takamura

et al. 2018

BioMed Research International

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A human skeleton of a middle-aged adult male was found in a 5th–6th century Kinoue-Kodo stone coffin excavated from the southwest marginal region of the Oita plains, northeast Kyushu, Japan. The skeleton was buried respectfully in the ancient tomb, and red pigment was applied to his face after death. We report herein findings from computed tomography imaging of the skeleton and discuss the multiple osteoblastic lesions identified in the humerus, scapula, clavicle, vertebra, pelvic bones, and skull of this individual. These lesions comprised cortical bone thickening with periosteal reaction localized to the surface and osteosclerotic changes mainly observed in the trabecular structure of cancellous bone. In particular, a typical sunburst pattern was also noted on the left scapula as another characteristic lesion found in this case. By differential diagnosis, the disease suffered by this individual was most likely to be metastatic bone tumors, especially of prostate cancer. This person may have survived until many bone metastases had developed throughout his whole body.

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Spiculated periosteal reaction in metastatic lesions of bone

Cited by 19 publications

References 2 publications

Primary osteosarcoma of the ribs: CT findings

Primary osteosarcoma of the ribs: CT findings

Case study of radial fibrolamellar bone tissues in the outer cortex of basal sauropods

An Ancient Skeleton with Multiple Osteoblastic Bone Lesions Containing a Scapular Sunburst Appearance from a 5th–6th Century Grave Excavated in Oita, Japan

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