Spicy and Aromatic Plants for Meat and Meat Analogues Applications

Marc, Romina Alina; Mureșan, Vlad; Mureşan, Crina; Tanislav, Anda Elena; Pușcaș, Andreea; Petruţ, Georgiana; Ungur, Rodica

doi:10.3390/plants11070960

Cited by 14 publications

(5 citation statements)

References 157 publications

(182 reference statements)

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“…In support of the abovementioned outcomes, the results of in silico screening also highlighted the importance of rosmarinic acid, which presented the highest binding affinity for AR among the selected compounds [66]. Therefore, the herbs M. spicata, O. vulgare and T. capitatus, which contain high amounts of rosmarinic acid and belong to the Lamiaceae family [67][68][69], show promise as herbal preparations with considerable antihyperglycemic activity. Special focus should be paid to T. capitatus because its putative action against hyperglycemia-related conditions may be attributed to the synergistic effect of rosmarinic acid and naringenin, which also presented putative binding affinity against AR [70].…”

Section: Phytochemical Phenolic Profile Of the Examined Infusion By L...mentioning

confidence: 53%

Assessing the Phytochemical Profile and Potential of Traditional Herbal Infusions against Aldose Reductase through In Silico Studies and LC-MS/MS Analysis

et al. 2022

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In the current market, there is a growing interest in traditional herbal nutraceuticals. Therefore, herbal formulations have re-emerged as products with sought-after nutraceutical and disease-preventing properties. The health-promoting effects of herbal bioactives are attributed to the active phytoconstituents of these plants. Thus, the aim of the present study was to evaluate the putative nutraceutical effectiveness of the preparations of ten herbs (chamomile, purple coneflower, lemon verbena, pennyroyal, spearmint, oregano, marjoram, headed savory, sea buckthorn, and St. John’s wort) by combining in silico techniques and LC-MS/MS analysis. The binding potential of the selected phenolic compounds, according to literature and web databases, was investigated by using molecular target prediction tools. Aldose reductase (AR), an enzyme of polyol pathway which is related to hyperglycemic-induced pathologies, emerged as the most promising molecular target. The molecular docking results showed that rosmarinic acid, caftaric acid, naringenin, and quercetin presented the highest binding affinity. In a further step, the phytochemical profile of the examined infusions, obtained by LC-MS/MS analysis, revealed that the abovementioned compounds were present, mainly in the herbs of the Lamiaceae family, designating headed savory as the herbal infusion with possible significant inhibitory activity against AR.

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Section: Phytochemical Phenolic Profile Of the Examined Infusion By L...mentioning

confidence: 53%

Assessing the Phytochemical Profile and Potential of Traditional Herbal Infusions against Aldose Reductase through In Silico Studies and LC-MS/MS Analysis

et al. 2022

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“… 21 Some polyphenol compounds present in O. basilicum are apigenin-7-glucuronide, dihydrokaempferol-3-glucoside, and aesculetin. 22 , 23 The previous study reported that apigenin-7-glucuronide has antimicrobial activity against Staphylococcus epidermidis, Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris , and Pseudomonas aeruginosa . 24 Dihydrokaempferol-3-glucoside was reported to have antioxidant activity of 1.0 mmol Trolox/mmol by Trolox equivalent assay.…”

Section: Discussionmentioning

confidence: 99%

In silico Study of Antiviral Activity of Polyphenol Compounds from Ocimum basilicum by Molecular Docking, ADMET, and Drug-Likeness Analysis

Kurnia¹,

Putri²,

Tumilaar³

et al. 2023

AABC

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The SARS-CoV-2 virus is a disease that has mild to severe effects on patients, which can even lead to death. One of the enzymes that act as DNA replication is the main protease, which becomes the main target in the inhibition of the SARS-CoV-2 virus. In finding effective drugs against this virus, Ocimum basilicum is a potential herbal plant because it has been tested to have high phytochemical content and bioactivity. Apigenin-7-glucuronide, dihydrokaempferol-3-glucoside, and aesculetin are polyphenolic compounds found in Ocimum basilicum. Purpose: The purpose of this study was to analyze the mechanism of inhibition of the three polyphenolic compounds in Ocimum basilicum against the main protease and to predict pharmacokinetic activity and the drug-likeness of a compound using the Lipinski Rule of Five. Patients and Methods: The method used is to predict the molecular docking inhibition mechanism using Autodock 4.0 tools and use pkcsm and protox online web server to analyze ADMET and Drug-likeness. Results:The binding affinity for apigenin-7-glucuronide was −8.77 Kcal/mol, dihydrokaempferol-3-glucoside was −8.96 Kcal/mol, and aesculetin was −5.79 Kcal/mol. Then, the inhibition constant values were 375.81 nM, 270.09 nM, and 57.11 µM, respectively. Apigenin-7-glucuronide and dihydrokaempferol-3-glucoside bind to the main protease enzymes on the active sites of CYS145 and HIS41, while aesculetin only binds to the active sites of CYS145. On ADMET analysis, these three compounds met the predicted pharmacokinetic parameters, although there are some specific parameters that must be considered especially for aesculetin compounds. Meanwhile, on drug-likeness analysis, apigenin-7-glucuronide and dihydrokaempferol-3-glucoside compounds have one violation and aesculetin have no violation. Conclusion: Based on the data obtained, Apigenin-7-glucuronide and dihydrokaempferol-3-glucoside are compounds that have more potential to have an antiviral effect on the main protease enzyme than aesculetin. Based on pharmacokinetic parameters and druglikeness, three compounds can be used as lead compounds for further research.

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“…Dried onions, dried garlic, curry powder, black pepper, garlic, chili, paprika and ginger are among the most widely used spice mixtures [120]. According to Vlaic et al [178], the most widely used aromatic plants in plant-based meat production are parsley, dill, basil, oregano, sage, coriander, rosemary, marjoram, tarragon, bay, thyme and mint. The mentioned herbs contain bioactive molecules that can have a beneficial effect on human health.…”

Section: Spicesmentioning

confidence: 99%

An Overview of Ingredients Used for Plant-Based Meat Analogue Production and Their Influence on Structural and Textural Properties of the Final Product

Benković,

Jurinjak Tušek,

Sokač Cvetnić

et al. 2023

Gels

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Plant-based meat analogues are food products made from vegetarian or vegan ingredients that are intended to mimic taste, texture and appearance of meat. They are becoming increasingly popular as people look for more sustainable and healthy protein sources. Furthermore, plant-based foods are marketed as foods with a low carbon footprint and represent a contribution of the consumers and the food industry to a cleaner and a climate-change-free Earth. Production processes of plant-based meat analogues often include technologies such as 3D printing, extrusion or shear cell where the ingredients have to be carefully picked because of their influence on structural and textural properties of the final product, and, in consequence, consumer perception and acceptance of the plant-based product. This review paper gives an extensive overview of meat analogue components, which affect the texture and the structure of the final product, discusses the complex interaction of those ingredients and reflects on numerous studies that have been performed in that area, but also emphasizes the need for future research and optimization of the mixture used in plant-based meat analogue production, as well as for optimization of the production process.

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Spicy and Aromatic Plants for Meat and Meat Analogues Applications

Cited by 14 publications

References 157 publications

Assessing the Phytochemical Profile and Potential of Traditional Herbal Infusions against Aldose Reductase through In Silico Studies and LC-MS/MS Analysis

Assessing the Phytochemical Profile and Potential of Traditional Herbal Infusions against Aldose Reductase through In Silico Studies and LC-MS/MS Analysis

In silico Study of Antiviral Activity of Polyphenol Compounds from Ocimum basilicum by Molecular Docking, ADMET, and Drug-Likeness Analysis

An Overview of Ingredients Used for Plant-Based Meat Analogue Production and Their Influence on Structural and Textural Properties of the Final Product

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