Spider bite‐induced pagetoid reticulosis?

Görpelioğlu, Canan; Sarıfakıoğlu, Evren; Haltas, Hacer

doi:10.1111/j.1468-3083.2008.02899.x

Cited by 2 publications

(4 citation statements)

References 8 publications

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“…Often atypical T‐cells are found along the dermoepidermal junction, in the dermis, and within Pautrier's microabscesses in MFPP and classical MF, while our analysis revealed minimal dermal infiltrate in WKD 25 . Importantly, the phenotypic expression of atypical T‐cells in MF is predominantly CD4+/CD8‐ while CD4‐/CD8+ T lymphocytes are more common in WKD 13 . With the exception of its disseminated subtype, WKD is a localized cutaneous pathology with no risk of extracutaneous transformation into lymphoma, which is more likely in classic MF 16,22 …”

Section: Discussionmentioning

confidence: 55%

“…Pruritus, for example, was described in a case of WKD on the plantar aspect of the foot 12 . The pain was a presenting symptom in a patient who reported a spider bite on the hand that preceded the cutaneous eruption of the lesion 13 . Less commonly, it may exhibit locally aggressive behavior without dissemination, even doubling in size over the course of 3 months 14 .…”

Section: Discussionmentioning

confidence: 99%

“…12 The pain was a presenting symptom in a patient who reported a spider bite on the hand that preceded the cutaneous eruption of the lesion. 13 Less commonly, it may exhibit locally aggressive behavior without dissemination, even doubling in size over the course of 3 months. 14 In fact, our review found a rapid increase in size to be characteristic in 27 cases of WKD.…”

Section: Patient Characteristics and Clinical Presentationmentioning

confidence: 99%

“…25 Importantly, the phenotypic expression of atypical T-cells in MF is predominantly CD4+/CD8-while CD4-/CD8+ T lymphocytes are more common in WKD. 13 With the exception of its disseminated subtype, WKD is a localized cutaneous pathology with no risk of extracutaneous transformation into lymphoma, which is more likely in classic MF. 16,22 CD8+ AECTCL can be differentiated from WKD based on an acute presentation of plaques in multiple body sites, which may be ulcerated and have mucosal involvement.…”

Section: Mfpp and Classical Mf Often Present With Multiple Lesionsmentioning

confidence: 99%

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Woringer‐Koloppdisease (localized pagetoid reticulosis): a systematic review

et al. 2022

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Objective Woringer-Kolopp disease (WKD), also known as localized pagetoid reticulosis, is a rare variant of mycosis fungoides as described by the World Health Organization-European Organization for Research and Treatment of Cancer (WHO-EORTC) classification system for cutaneous lymphomas. Our objective was to conduct a comprehensive review that describes and evaluates patient demographics, clinical presentation, immunohistochemical findings, management, and outcomes of WKD. Methods The databases PubMed, Embase, and Cochrane Library were searched for relevant literature. Patient demographics, imaging, treatments, and other clinical characteristics were obtained. The literature search was conducted on December 7, 2020.Studies were included if they contained primary data related to WKD. Non-pertinent studies, non-English studies, non-human studies, review articles, or studies with insufficient case information were excluded. The quality of the included studies and the risk of bias were evaluated using the Grades of Recommendation, Assessment, Development, and Evaluation Group (GRADE) criteria ( 2016), Oxford Centre for Evidence-Based Medicine: Levels of Evidence (OCEBM) (March 2009), and the Methodological Index for Non-Randomized Studies (MINORS) criteria (2003).Results A total of 84 studies with 143 patients met the inclusion criteria for this study. The most common chief complaint was an asymptomatic, slow-growing, and erythematous plaque. The average time from initial skin eruption to presentation was 97.6 months.Histologically, 128 cases of WKD displayed epidermotropism (97.7%). Various therapies, including radiotherapy, surgery, and local chemotherapy, were used. In total, 92 (78.6%) cases had complete remission and 11 (9.4%) cases recurred. Conclusions WKD is a rare cutaneous T-cell lymphoma that often presents as a single plaque on the extremities with an indolent course and a favorable prognosis. However, it is often misdiagnosed, leading to delays in treatment. The diagnosis of WKD involves clinical appraisal, a biopsy of suspicious lesions, and immunohistochemistry. Monotherapy appears to be preferred compared to combination therapy for WKD with radiotherapy demonstrating among the highest cure rates and lowest recurrence. Future retrospective and prospective studies are needed to accurately determine the epidemiology, prognosis, and effective treatments for WKD. Limitations include a possibility of missed studies, heterogeneity in reporting methods, publication, and selection bias.What is already known about this topic?• Woringer-Kolopp disease (WKD) is a rare variant of mycosis fungoides as described by the World Health Organization-European Organization for Research and Treatment of Cancer (WHO-EORTC) classification system for cutaneous lymphomas.• Qualitative systematic analysis can generate new insights compared to individual findings.What does this study add?• Demonstrates the need for accurate diagnosis of Cutaneous T-Cell Lymphomas.

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Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 99%