Spider diagram and Analytical GREEnness metric approach for assessing the greenness of quantitative 1H-NMR determination of lamotrigine: Taguchi method based optimization

Abou-Taleb, Noura H.; El‐Enany, N.; El-Sherbiny, Dina T.; El‐Subbagh, Hussein I.

doi:10.1016/j.chemolab.2020.104198

Cited by 21 publications

(10 citation statements)

References 35 publications

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“…Many chemical reagents do not provide all of the necessary information regarding the five aforementioned subgroups on an SDS, so this missed data had a zero score in calculation. The portion of accessible data required to generate the Greenness Index values, along with all the missing data, are released in a data table referred to as the “Greenness Index Table.” The degree of confidence in the greenness judgment is indicated by these references [ [38] , [39] , [40] ].…”

Section: Greenness Protocolsmentioning

confidence: 99%

“…We must point out that the key to achieving perfect greenness analytical methods is choosing the environmental solvent, so the greenness evaluation of the solvent includes safety, health, and environment (SHE) impact, all of which must be taken into account. This has been achieved through Greenness Index and spider diagram tools [ [38] , [39] , [40] ].…”

Section: Introductionmentioning

confidence: 99%

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Spider diagram and sustainability evaluation of UV-methods strategy for quantification of aspirin and sildenafil citrate in the presence of salicylic acid in their bulk and formulation

Kayali¹,

Obaydo²,

Sakur³

2023

Heliyon

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Section: Greenness Protocolsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Spider diagram and sustainability evaluation of UV-methods strategy for quantification of aspirin and sildenafil citrate in the presence of salicylic acid in their bulk and formulation

Kayali¹,

Obaydo²,

Sakur³

2023

Heliyon

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“…However, once installed, the NMR spectrometer has a high performance in routine utilization. As recently demonstrated, quantitative NMR often shows green performance higher than liquid chromatography, for example, because it requires little solvent and no separate standard samples (or very few in a session) …”

Section: Resultsmentioning

confidence: 99%

NMR-Based Method for Intramolecular ¹³C Distribution at Natural Abundance Adapted to Small Amounts of Glucose

et al. 2023

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Quantitative nuclear magnetic resonance (NMR) for isotopic measurements, known as irm-NMR (isotope ratio measured by NMR), is well suited for the quantitation of 13C-isotopomers in position-specific isotope analysis and thus for measuring the carbon isotope composition (δ13C, mUr) in C-atom positions. Irm-NMR has already been used with glucose after derivatization to study sugar metabolism in plants. However, up to now, irm-NMR has exploited a “single-pulse” sequence and requires a relatively large amount of material and long experimental time, precluding many applications with biological tissues or extracts. To reduce the required amount of sample, we investigated the use of 2D-NMR analysis. We adapted and optimized the NMR sequence so as to be able to analyze a small amount (10 mg) of a glucose derivative (diacetonide glucofuranose, DAGF) with a precision better than 1 mUr at each C-atom position. We also set up a method to correct raw data and express 13C abundance on the usual δ13C scale (δ-scale). In fact, due to the distortion associated with polarization transfer and spin manipulation during 2D-NMR analyses, raw 13C abundance is found to be on an unusual scale. This was compensated for by a correction factor obtained via comparative analysis of a reference material (commercial DAGF) using both previous (single-pulse) and new (2D) sequences. Glucose from different biological origins (CO2 assimilation metabolisms of plants, namely, C3, C4, and CAM) was analyzed with the two sequences and compared. Validation criteria such as selectivity, limit of quantification, precision, trueness, and robustness are discussed, including in the framework of green analytical chemistry.

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“…The greenness of methods is gradually being taken seriously by researchers. The Analytical GREEnness metric approach (AGREE) is a novel, easily interpretable, and informative assessment approach ( 46 ). In our study AGREE tools were applied to evaluate the greenness of the developed analytical method.…”

Section: Resultsmentioning

confidence: 99%

Discrimination of Geographical Origin of Agricultural Products From Small-Scale Districts by Widely Targeted Metabolomics With a Case Study on Pinggu Peach

et al. 2022

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Geographical indications of agricultural products are characterized by high quality and regional attributes, while they are more likely to be counterfeited by similar products from nearby regions. Accurate discrimination of origin on small geographical scales is extremely important for geographical indications of agricultural products to avoid food fraud. In this study, a widely targeted metabolomics based on ultra-high-performance liquid chromatography–tandem mass spectrometry combined with multivariate statistical analysis was used to distinguish the geographical origin of Pinggu Peach of Beijing and its two surrounding areas in Heibei province (China). Orthogonal partial least squares-discriminant analysis (OPLS-DA) based on 159 identified metabolites showed significant separation from Pinggu and the other adjacent regions. The number of the most important discriminant variables (VIP value >1) was up to 62, which contributed to the differentiation model. The results demonstrated that the metabolic fingerprinting combined with OPLS-DA could be successfully implemented to differentiate the geographical origin of peach from small-scale origins, thus providing technical support to further ensure the authenticity of geographical indication products. The greenness of the developed method was assessed using the Analytical GREEnness Metric Approach and Software (ARGEE) tool. It was a relatively green analytical method with room for improvement.

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Spider diagram and Analytical GREEnness metric approach for assessing the greenness of quantitative 1H-NMR determination of lamotrigine: Taguchi method based optimization

Cited by 21 publications

References 35 publications

Spider diagram and sustainability evaluation of UV-methods strategy for quantification of aspirin and sildenafil citrate in the presence of salicylic acid in their bulk and formulation

Spider diagram and sustainability evaluation of UV-methods strategy for quantification of aspirin and sildenafil citrate in the presence of salicylic acid in their bulk and formulation

NMR-Based Method for Intramolecular ¹³C Distribution at Natural Abundance Adapted to Small Amounts of Glucose

Discrimination of Geographical Origin of Agricultural Products From Small-Scale Districts by Widely Targeted Metabolomics With a Case Study on Pinggu Peach

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Spider diagram and Analytical GREEnness metric approach for assessing the greenness of quantitative 1H-NMR determination of lamotrigine: Taguchi method based optimization

Cited by 21 publications

References 35 publications

Spider diagram and sustainability evaluation of UV-methods strategy for quantification of aspirin and sildenafil citrate in the presence of salicylic acid in their bulk and formulation

Spider diagram and sustainability evaluation of UV-methods strategy for quantification of aspirin and sildenafil citrate in the presence of salicylic acid in their bulk and formulation

NMR-Based Method for Intramolecular 13C Distribution at Natural Abundance Adapted to Small Amounts of Glucose

Discrimination of Geographical Origin of Agricultural Products From Small-Scale Districts by Widely Targeted Metabolomics With a Case Study on Pinggu Peach

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Product

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NMR-Based Method for Intramolecular ¹³C Distribution at Natural Abundance Adapted to Small Amounts of Glucose