Spider Silk Coatings as a Bioshield to Reduce Periprosthetic Fibrous Capsule Formation

Water-based preparation of spider silk films as drug delivery matrices

“…The use of eADF4(C16) proteins as polymeric matrix offers several advantages. Among these are its biocompatibility [18], as well as the ability to be naturally degraded in the human body by proteases, leading to non-toxic degradation products (amino acids), and avoiding any additional surgery to remove the DDS. M A N U S C R I P T ACCEPTED MANUSCRIPT 1.3.…”

“…This engineered protein composes primarily the natural spider protein ADF-4 produced by the spider araneus diadematus (the common European garden spider). In one recent study [18], medical grade silicone implants have been coated with this recombinant spider silk protein. During an in vivo study using Sprague-Dawley rats as models, no detectable immunological reactions have been observed due to the presence of the coating.…”

Biofabrication of 3D constructs: fabrication technologies and spider silk proteins as bioinks

“…Silk-based biomaterials have been used for medical sutures and breast implant coatings [70][71][72], biosensing applications [73], and enzyme immobilization [74][75][76]. Recently, a silk-gelatin blend was used as a bioink [20,57].…”

Silk Hydrogels for Drug and Cell Delivery

“…spider silks manufactured by AMSilk, Munich, Germany]; these clinical studies were preceded by successful in vivo studies that showed no acute systemic toxicity and immunogenicity with eADF4(C16), as well as a significant reduction in capsule formation with the silk-coated silicon implants (Zeplin, Maksimovikj et al 2014). In particular, the successful track record of silk sutures for use in humans has served as the launching platform for the development of silk-based materials for biomedical applications, including cell and drug delivery.…”