Spike Timing–Dependent Plasticity: A Hebbian Learning Rule

Abstract

Spike timing-dependent plasticity (STDP) as a Hebbian synaptic learning rule has been demonstrated in various neural circuits over a wide spectrum of species, from insects to humans. The dependence of synaptic modification on the order of pre- and postsynaptic spiking within a critical window of tens of milliseconds has profound functional implications. Over the past decade, significant progress has been made in understanding the cellular mechanisms of STDP at both excitatory and inhibitory synapses and of the associated changes in neuronal excitability and synaptic integration. Beyond the basic asymmetric window, recent studies have also revealed several layers of complexity in STDP, including its dependence on dendritic location, the nonlinear integration of synaptic modification induced by complex spike trains, and the modulation of STDP by inhibitory and neuromodulatory inputs. Finally, the functional consequences of STDP have been examined directly in an increasing number of neural circuits in vivo.

Closed-loop brain training: the science of neurofeedback

“…Extant literature holds that long-term potentiation (LTP) is a central mechanism underlying associative learning 186 . Recent research has focused on a form of LTP called spike timing-dependent plasticity (STDP) 187 . According to STDP, a modification in synaptic transmission occurs owing to variations in the timing of weak and strong synaptic inputs over tens of milliseconds.…”

A Minimal Spiking Neural Network to Rapidly Train and Classify Handwritten Digits in Binary and 10-Digit Tasks

“…STDP is a learning rule which modifies the synaptic strength (weight) between two neurons as a function of the relative pre-and postsynaptic spike occurrence times [12]. Competitive learning takes the form of a winnertake-all (WTA) policy.…”

A neurociência computacional no estudo dos processos cognitivos

“…Hebb organized his ideas into three premises: (i) the first proposes that two neurons undergo metabolic and/or structural alterations when their activation patterns are correlated, for facilitation of transmission between these neurons; (ii) the second proposes that neurons that have correlated activities form a 'cell assembly' that have functional connection; (iii) the third presents a temporally concatenated activation of several cell assemblies, called 'phase sequence,' just as the flow of thought itself (Crick & Koch, 1990;Hebb, 1944Hebb, /2002. Since then, many experimental and theoretical studies have confirmed, revised, and expanded the largely theoretical and qualitative work performed by Hebb (Bliss & Lomo, 1973;Brown, Kairiss, & Keenan, 1990;Caporale & Dan, 2008;Crick & Koch, 1990;Kolb, 2003;Lechner & Byrne, 1998).…”