Spike-triggered average electrical stimuli as input filters for bionic vision—a perspective

Rathbun, Daniel L.; Ghorbani, Nima; Shabani, H; Zrenner, Eberhart; Hosseinzadeh, Zohreh

doi:10.1088/1741-2552/aae493

Cited by 22 publications

(29 citation statements)

References 113 publications

(154 reference statements)

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“…System identification approaches to estimate preferred stimuli of neurons are always limited to finding the preferred stimulus within the subspace that is spanned by the presented stimuli; if the true preferred stimulus ) between predicted and true firing rate at a resolution of 1 kHz, evaluated separately for the three identified clusters among wt filters, as well as for rd10 filters. (2020) 10:5248 | https://doi.org/10.1038/s41598-020-61899-y www.nature.com/scientificreports www.nature.com/scientificreports/ is not in this subspace, it can only be approximated by the most closely matching stimulus within the subspace that was sampled 35,49 . Our smooth electrical stimulus broadly, but certainly not exhaustively, samples stimulus space, simultaneously probing different stimulus dimensions like frequency, amplitude and polarity.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, investigating network-mediated electrical activation of rat RGC, ON cells were found to prefer anodic-first biphasic pulses, and OFF cells to prefer cathodic-first pulses, but the difference in preference was small 39 . Antagonistic polarities of electrical filters in wild-type mouse ON and OFF cells have been reported as well 41 ; however, the clinical applicability of these filters as stimuli is limited as they most likely arose due to photoreceptor activation 49 .…”

Section: Discussionmentioning

confidence: 99%

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Probing and predicting ganglion cell responses to smooth electrical stimulation in healthy and blind mouse retina

Höfling

Oesterle

Berens

et al. 2020

Sci Rep

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Retinal implants are used to replace lost photoreceptors in blind patients suffering from retinopathies such as retinitis pigmentosa. Patients wearing implants regain some rudimentary visual function. However, it is severely limited compared to normal vision because non-physiological stimulation strategies fail to selectively activate different retinal pathways at sufficient spatial and temporal resolution. The development of improved stimulation strategies is rendered difficult by the large space of potential stimuli. Here we systematically explore a subspace of potential stimuli by electrically stimulating healthy and blind mouse retina in epiretinal configuration using smooth Gaussian white noise delivered by a high-density CMOS-based microelectrode array. We identify linear filters of retinal ganglion cells (RGCs) by fitting a linear-nonlinear-Poisson (LNP) model. Our stimulus evokes spatially and temporally confined spiking responses in RGC which are accurately predicted by the LNP model. Furthermore, we find diverse shapes of linear filters in the linear stage of the model, suggesting diverse preferred electrical stimuli of RGCs. The linear filter base identified by our approach could provide a starting point of a model-guided search for improved stimuli for retinal prosthetics.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Probing and predicting ganglion cell responses to smooth electrical stimulation in healthy and blind mouse retina

Höfling

Oesterle

Berens

et al. 2020

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Indeed, investigating network-mediated electrical activation of rat RGC, ON cells were found to prefer cathodic-first biphasic pulses, and OFF cells to prefer anodic-first pulses, but the difference in preference was small 33 . Antagonistic polarities of electrical filters in wild-type mouse ON and OFF cells have been reported as well 35 ; however, the clinical applicability of these filters as stimuli is limited as they most likely arose due to photoreceptor activation 40 . In this study, we found three different classes of RGC filters in response to smooth electrical stimulation in wild-type, and one class of filter in photoreceptor-degenerated mouse retina.…”

Section: Discussionmentioning

confidence: 99%

Probing and predicting ganglion cell responses to smooth electrical stimulation in healthy and blind mouse retina

Hoefling

Berens

Zeck

2019

Preprint

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Retinal implants are used to replace lost photoreceptors in blind patients suffering from retinopathies such as retinitis pigmentosa. Patients wearing implants regain some rudimentary visual function. However, it is severely limited compared to normal vision because non-physiological stimulation strategies fail to selectively activate different retinal pathways at sufficient spatial and temporal resolution. The development of improved stimulation strategies is rendered difficult by the large space of potential stimuli. Here we systematically explore a subspace of potential stimuli by electrically stimulating healthy and blind mouse retina in epiretinal configuration using smooth Gaussian white noise delivered by a high-density CMOS-based microelectrode array. We identify linear filters of retinal ganglion cells (RGCs) by fitting a linear-nonlinear-Poisson (LNP) model. Our stimulus evokes fast, reliable, and spatially confined spiking responses in RGC which are accurately predicted by the LNP model. Furthermore, we find diverse shapes of linear filters in the linear stage of the model, suggesting diverse preferred electrical stimuli of RGCs. Our smooth electrical stimulus could provide a starting point of a model-guided search for improved stimuli for retinal prosthetics.

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“…This distortion is caused by the activation of the axon of passages, which is a main limitation of epi-retinal prostheses. However, several approaches were recently reported to overcome the direct activation of retinal ganglion cells and favour the network-medicated activation, mainly based on waveform shaping [34,35] and input filters [36]. In humans, it was also demonstrated that long sinusoidal-like pulses promote the perception of circular phosphenes [37].…”

Section: Discussionmentioning

confidence: 99%

Virtual reality simulation of epi-retinal prosthetic vision highlights the relevance of the visual angle

Thorn

Migliorini

Ghezzi

2020

Preprint

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Objective. Retinal prostheses hold the potential to restore artificial vision in blind patients suffering from outer retinal dystrophies. The optimal number, density, and coverage of the electrodes that a retinal prosthesis should have to provide adequate artificial vision in daily activities is still an open question and an important design parameter needed to develop better implants. Approach. To address this question, we investigated the interaction between the visual angle, the pixel number and the pixel density without being limited by a small electrode count, as in previous research reports. We implemented prosthetic vision in a virtual reality environment in order to simulate the real-life experience of using a retinal prosthesis. We designed four different tasks simulating: object recognition, word reading, perception of a descending step and crossing a street. Main results. The results of our study showed that in all the tasks the visual angle played the most significant role in improving the performance of the participant. Significance. The design of new retinal prostheses should take into account the relevance of the restored visual angle to provide a helpful and valuable visual aid to profoundly or totally blind patients.

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Spike-triggered average electrical stimuli as input filters for bionic vision—a perspective

Abstract: Spike-triggered average electrical stimuli as input filters for bionic vision-a perspective.

Cited by 22 publications

References 113 publications

Probing and predicting ganglion cell responses to smooth electrical stimulation in healthy and blind mouse retina

Probing and predicting ganglion cell responses to smooth electrical stimulation in healthy and blind mouse retina

Probing and predicting ganglion cell responses to smooth electrical stimulation in healthy and blind mouse retina

Virtual reality simulation of epi-retinal prosthetic vision highlights the relevance of the visual angle

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