Spike-wave seizures, slow-wave sleep EEG and morphology of substantia nigra pars compacta in WAG/Rij rats with genetic predisposition to absence epilepsy

Sitnikova, Evgenia; Rutskova, Elizaveta; Tsvetaeva, Daria; Raevsky, V. V.

doi:10.1016/j.brainresbull.2021.06.003

Cited by 5 publications

(3 citation statements)

References 32 publications

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“…Considering that sleep cycle in WAG/Rij rats was shorter than that in control inbred Black agouti ACI rats (42), spike-wave epilepsy results in shortening of sleep cycle. Second, fragmentation of slow-wave sleep in "epileptic" WAG/Rij rats (44). In 9-11-month-old WAG/Rij rats, we found negative correlations between the number of slow-wave sleep episodes and their mean duration, which was interpreted as sleep fragmentation (44).…”

Section: Thalamocortical Oscillations and Slow-wave Sleepmentioning

confidence: 72%

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Sleep Disturbances in Rats With Genetic Pre-disposition to Spike-Wave Epilepsy (WAG/Rij)

Sitnikova

2021

Front. Neurol.

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Wistar Albino Glaxo Rijswijk (WAG/Rij) rats are widely used in basic and pre-clinical studies as a valid genetic model of absence epilepsy. Adult WAG/Rij rats exhibit generalized 8–10-Hz spike-wave discharges (SWDs) in the electroencephalogram. SWDs are known to result from thalamocortical circuit dysfunction, and this implies an intimate relationship between slow-wave EEG activity, sleep spindles, and SWDs. The present mini review summarizes relevant research on sleep-related disturbances associated with spike-wave epilepsy in WAG/Rij rats in the domain of slow-wave sleep EEG and microarousals. It also discusses enhancement of the intermediate stage of sleep. In general, sleep EEG studies provide important information about epileptogenic processes related to spike-wave epilepsy.

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Section: Thalamocortical Oscillations and Slow-wave Sleepmentioning

confidence: 72%

“…Second, fragmentation of slow-wave sleep in "epileptic" WAG/Rij rats (44). In 9-11-month-old WAG/Rij rats, we found negative correlations between the number of slow-wave sleep episodes and their mean duration, which was interpreted as sleep fragmentation (44).…”

Section: Thalamocortical Oscillations and Slow-wave Sleepmentioning

confidence: 72%

Sleep Disturbances in Rats With Genetic Pre-disposition to Spike-Wave Epilepsy (WAG/Rij)

Sitnikova

2021

Front. Neurol.

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“…Slow waves have various manifestations in epileptic seizures, including spike-slow wave, multi-spike slow wave, sharp slow wave and other wave types, which are collectively called epileptiform discharges. The spike-slow wave complex rhythm is more common in minor absence seizures ( Sitnikova et al., 2021 ), and a spike-slow wave is the most common in Lennox-Gastaut syndrome ( Thiele et al., 2018 ). Although focal and regional background slowdown (theta and delta) is a nonspecific finding in patients with epilepsy ( Jan et al., 2010 ), rhythmic theta activity is a common attack pattern in temporal lobe epilepsy (TLE) ( Rosenow et al., 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Intestinal Flora Composition Determines Microglia Activation and Improves Epileptic Episode Progress

Ding

Zhou

Zhao

et al. 2022

Front. Cell. Infect. Microbiol.

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In response to environmental stimuli, immune memory mediates the plasticity of myeloid cells. Immune training and immune tolerance are two aspects of plasticity. Microglia that are immunologically trained or immunologically tolerant are endowed with a tendency to differentiate into alternative dominant phenotypes (M1/M2). Male C57BL/6 mice (immune-training group, immune-tolerant group, and control group) were used to establish the kainic acid epilepsy model. The seizure grade, duration, latency, hippocampal potential, and energy density were used to evaluate seizures, and the changes in the polarization of microglia were detected by western blot. 16S rDNA sequencing showed that the abundance of Ruminococcus in the immune-tolerant group was the dominant flora. Our research connections Intestinal microorganisms, brain immune status, and epilepsy behavior together. Pro-inflammatory M1 phenotype and anti-inflammatory M2 phenotype mediate and enhance and suppress subsequent inflammation, respectively. We conclude that intestinal microorganisms influence the occurrence and development of epilepsy by regulating the polarization of microglia.

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Whisker trimming during infanthood modifies the development of spike-wave discharges and behavioral sequences in IntelliCage impulsivity paradigm in adult WAG/Rij rats

Esmaeili

Antonova

Sitnikova

et al. 2022

Behavioural Brain Research

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Spike-wave seizures, slow-wave sleep EEG and morphology of substantia nigra pars compacta in WAG/Rij rats with genetic predisposition to absence epilepsy

Cited by 5 publications

References 32 publications

Sleep Disturbances in Rats With Genetic Pre-disposition to Spike-Wave Epilepsy (WAG/Rij)

Sleep Disturbances in Rats With Genetic Pre-disposition to Spike-Wave Epilepsy (WAG/Rij)

Intestinal Flora Composition Determines Microglia Activation and Improves Epileptic Episode Progress

Whisker trimming during infanthood modifies the development of spike-wave discharges and behavioral sequences in IntelliCage impulsivity paradigm in adult WAG/Rij rats

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